N-acetyl cysteine reduces chromosomal DNA damage in circulating lymphocytes during cardiac catheterization procedures: A pilot study

International Journal of Cardiology

Volumn 161, Issue 2, 2012, Pages 93-96

  Andreassi, Maria Grazia ^a   Cioppa, Angelo ^b   Manfredi, Samantha ^a   Neri, Maria Giovanna ^a   Foffa, Ilenia ^a   Picano, Eugenio ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b Montevergine Clinic   (Italy)

Author keywords

DNA damage; Ionizing radiation; NAC

Indexed keywords

ACETYLCYSTEINE; CONTRAST MEDIUM; DNA; SODIUM CHLORIDE;

ABLATION THERAPY; ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CELL PROTECTION; CONTINUOUS INFUSION; CONTRAST INDUCED NEPHROPATHY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; HEART CATHETERIZATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS TEST; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PILOT STUDY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; TIME;

ACETYLCYSTEINE; AGED; CARDIAC CATHETERIZATION; DNA DAMAGE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 84868678564     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.05.001     Document Type: Article

References (43)

1. S. Betsou, E.P. Efstathopoulos, D. Katritsis, K. Faulkner, and G. Panayiotakis Patient radiation doses during cardiac catheterisation procedures Br J Radiol 71 1998 634 639
2. E.P. Efstathopoulos, E. Karvouni, and S. Kottou Patient dosimetry during coronary interventions: a comprehensive analysis Am Heart J 147 2004 468 475
3. D. Kocinaj, A. Cioppa, and G. Ambrosiani Radiation dose exposure during cardiac and peripheral arteries catheterisation Int J Cardiol 113 2006 283 284
4. G. Bedetti, N. Botto, M.G. Andreassi, C. Traino, E. Vano, and E. Picano Cumulative patient effective dose in cardiology Br J Radiol 81 2008 699 705
5. Report of the United States Nations Scientific Committee on the Effects of Atomic Radiation to the General Assembly (UNSCEAR) Annex G. Biological effects at low radiation doses 2001
6. Committee to assess health risks from exposure to low levels of ionizing radiation; nuclear and radiation studies board, division on earth and life studies National Research Council of the National Academies: Health Risks From Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2 2006 The National Academies Press Washington, DC
7. International Commission on Radiological Protection Recommendations on the protection of man and the environment against ionising radiation http://www.icrp.org/ 2007
8. M.G. Andreassi Radiation risk from pediatric cardiac catheterization: friendly fire on congenital heart disease Circulation 120 2009 1847 1849
9. E.N. Karatzis, and P.G. Danias Exposure to ionizing radiation from cardiovascular imaging and therapeutic procedures may be a considerable unrecognized risk for subsequent cancer development J Am Coll Radiol 5 2008 694 695
10. D. Geisel, J.T. Heverhagen, M. Kalinowski, and H.J. Wagner DNA double-strand breaks after percutaneous transluminal angioplasty Radiology 248 2008 852 859
11. M.A. Kuefner, S. Grudzenski, and S.A. Schwab DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures Invest Radiol 44 2009 440 446
12. L. Beels, K. Bacher, D. De Wolf, J. Werbrouck, and H. Thierens γ2AX foci as biomarker for patient x-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks? Circulation 120 2009 1903 1909
13. L. Hagmar, S. Bonassi, and U. Stromberg Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH) Cancer Res 58 1998 4117 4121
14. S. Bonassi, A. Znaor, and M. Ceppi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans Carcinogenesis 28 2007 625 631
15. S. Bonassi, H. Norppa, and M. Ceppi Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries Carcinogenesis 29 2008 1178 1183
16. M.G. Andreassi, L. Ait-Ali, N. Botto, S. Manfredi, G. Mottola, and E. Picano Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease Eur Heart J 27 2006 2703 2708
17. M.G. Andreassi, A. Cioppa, S. Manfredi, C. Palmieri, N. Botto, and E. Picano Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures Eur Heart J 28 2007 2195 2199
18. L. Ait-Ali, M.G. Andreassi, I. Foffa, I. Spadoni, E. Vano, and E. Picano Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease Heart 96 2010 269 274
19. L.F. Miller, and B.H. Rumack Clinical safety of high oral doses of acetylcysteine Semin Oncol 10 1983 76 85
20. G.S. Kelly Clinical applications of N-acetylcysteine Altern Med Rev 1983 114 127
21. J. Kay, W.H. Chow, and T.M. Chan Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial JAMA 289 2003 553 557
22. W. Isenbarger, S.M. Kent, and P.G. O'Malley Meta-analysis of randomized clinical trials on the usefulness of acetylcysteine for prevention of contrast nephropathy Am J Cardiol 92 2003 1454 1458
23. A.M. Kelly, B. Dwamena, P. Cronin, S.J. Bernstein, and R.C. Carlos Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy Ann Intern Med 148 2008 284 294
24. J.W. Hirshfeld Jr., S. Balter, and J.A. Brinker American College of Cardiology Foundation; American Heart Association; HRS; SCAI; American College of Physicians Task Force on Clinical Competence and Training. ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College Circulation 111 2005 511 532
25. P. Jeggo, and M. Lobbrich Radiation-induced DNA damage responses Radiat Prot Dosimetry 122 2006 124 127
26. K.K. Khanna, and S.P. Jackson DNA double-strand breaks: signaling, repair and the cancer connection Nat Genet 27 2001 247 254
27. P.J. Millea N-acetylcysteine: multiple clinical applications Am Fam Physician 80 2009 265 269
28. J.F. Weiss, and M.R. Landauer Radioprotection by antioxidants Ann NY Acad Sci 899 2000 44 60
29. S. De Flora, A. Izzotti, F. D'Agostini, and R.M. Balansky Mechanism of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points Carcinogenesis 22 2001 999 1013
30. Y. Kataoka, V.P. Bindokas, R.C. Duggan, J.S. Murley, and D.J. Grdina Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells J Radiat Res 47 2006 245 257
31. Y. Kataoka, J.S. Murley, K.L. Baker, and D.J. Grdina Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs Radiat Res 168 2007 106 114
32. Y. Liu, H. Zhang, and L. Zhang Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice Eur J Pharmacol 575 2007 142 148
33. G. Abt, H. Vaghef, E. Gebhart, C.V. Dahlgren, and B. Hellman The role of N-acetylcysteine as a putative radioprotective agent on X-ray-induced DNA damage as evaluated by alkaline single-cell gel electrophoresis Mutat Res 384 1997 55 64
34. H.H. Mansour, H.F. Hafez, N.M. Fahmy, and N. Hanafi Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats Bioch Phar 75 2008 773 780
35. R. Reliene, J.M. Pollard, Z. Sobol, B. Trouiller, R.A. Gatti, and R.H. Schiestl N-acetyl cysteine protects against ionizing 17diation-induced DNA damage but not against cell killing in yeast and mammals Mutat Res 665 2009 37 43
36. P. Tiwari, A. Kumar, S. Balakrishnan, H.S. Kushwaha, and K.P. Mishra Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols Mutat Res 676 2009 62 68
37. White Paper: Initiative to Reduce Unnecessary Radiation Exposure from Medical Imaging. Food and Drug Administration. Initiative to reduce unnecessary radiation exposure. http://www.fda.gov/RadiationEmittingProducts/ RadiationSafety/RadiationDoseReduction/ucm199904.htm
38. F.A. Mettler Jr., B.R. Thomadsen, and M. Bhargavan Medical radiation exposure in the U.S. in 2006: preliminary results Health Phys 95 2008 502 507
39. E. Picano Risk of cancer from diagnostic X-rays Lancet 363 2004 1909 1910
40. A. Berrington de González, M. Mahesh, and K.P. Kim Projected cancer risks from computed tomographic scans performed in the United States in 2007 Arch Intern Med 169 2009 2071 2077
41. J. Chen, A.J. Einstein, and R. Fazel Cumulative exposure to ionizing radiation from diagnostic and therapeutic cardiac imaging procedures: a population-based analysis J Am Coll Cardiol 56 2010 702 711
42. President's Cancer Panel: Environmentally caused cancers are grossly underestimated and needlessly devastate American lives. http://www. environmentalhealthnews.org/ehs/news/presidents-cancer-panel
43. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150