The Myc 3'wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract

Molecular and Cellular Biology

Volumn 32, Issue 19, 2012, Pages 3891-3902

  Konsavage, Wesley M ^a   Jin, Ge ^a   Yochum, Gregory S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYC 3' PROTEIN; MYC PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL PROLIFERATION; COLITIS; CONTROLLED STUDY; CONVALESCENCE; DNA RESPONSIVE ELEMENT; GENE SILENCING; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; INTESTINE; INTESTINE ABSORPTION; INTESTINE INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE REGENERATION; WILD TYPE;

EID: 84868676912     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00548-12     Document Type: Article

References (44)

1. Ahmadiyeh N, et al. 2010. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc. Natl. Acad. Sci. U. S. A. 107:9742-9746.
2. Ashton GH, et al. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev. Cell 19:259 -269.
3. Athineos D, Sansom OJ. 2010. Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. Oncogene 29:2585-2590.
4. Barker N, et al. 2009. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457:608-611.
5. Baudino TA, et al. 2002. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 16:2530- 2543.
6. Bettess MD, et al. 2005. c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium. Mol. Cell. Biol. 25:7868 -7878.
7. Boismenu R, Chen Y. 2000. Insights from mouse models of colitis. J. Leukoc. Biol. 67:267-278.
8. Bottomly D, Kyler SL, McWeeney SK, Yochum GS. 2010. Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res. 38:5735-5745.
9. Clevers H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127:469-480.
10. Dang CV, et al. 2006. The c-Myc target gene network. Semin. Cancer Biol. 16:253-264.
11. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A. 1993. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7:671- 682.
12. Eilers M, Eisenman RN. 2008. Myc's broad reach. Genes Dev. 22:2755- 2766.
13. Finch AJ, Soucek L, Junttila MR, Swigart LB, Evan GI. 2009. Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol. Cell. Biol. 29:5306 -5315.
14. Hatzis P, et al. 2008. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol. Cell. Biol. 28:2732-2744.
15. He TC, et al. 1998. Identification of c-MYC as a target of the APC pathway. Science 281:1509 -1512.
16. Ignatenko NA, et al. 2006. Role of c-Myc in intestinal tumorigenesis of the ApcMin/mouse. Cancer Biol. Ther. 5:1658 -1664.
17. Jia L, et al. 2009. Functional enhancers at the gene-poor 8q24 cancerlinked locus. PLoS Genet. 5:e1000597. doi:10.1371/journal.pgen.1000597.
18. Koch S, et al. 2011. The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology 141:259 -268.
19. Korinek V, et al. 1998. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:379 -383.
20. Kuhnert F, et al. 2004. Essential requirement for Wnt signaling in prolif-eration of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. U. S. A. 101:266 -271.
21. Laroui H, et al. 2012. Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. PLoS One 7:e32084. doi:10.1371/journal-.pone.0032084.
22. MacDonald BT, Tamai K, He X. 2009. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17:9 -26.
23. Macpherson AJ, et al. 1992. Increased expression of c-myc protooncogene in biopsies of ulcerative colitis and Crohn's colitis. Gut 33:651- 656.
24. Mosimann C, Hausmann G, Basler K. 2009. Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat. Rev. Mol. Cell. Biol. 10:276 -286.
25. Muncan V, et al. 2006. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol. Cell. Biol. 26:8418- 8426.
26. Murphy DJ, et al. 2008. Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14:447- 457.
27. Nesbit CE, Tersak JM, Prochownik EV. 1999. MYC oncogenes and human neoplastic disease. Oncogene 18:3004 -3016.
28. Pinto D, Gregorieff A, Begthel H, Clevers H. 2003. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17:1709 -1713.
29. Pomerantz MM, et al. 2009. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet. 41:882- 884.
30. Sancho E, Batlle E, Clevers H. 2004. Signaling pathways in intestinal development and cancer. Annu. Rev. Cell Dev. Biol. 20:695-723.
31. Sansom OJ, et al. 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446:676-679.
32. Sierra J, Yoshida T, Joazeiro CA, Jones KA. 2006. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 20:586-600.
33. Sotelo J, et al. 2010. Long-range enhancers on 8q24 regulate c-Myc. Proc. Natl. Acad. Sci. U. S. A. 107:3001-3005.
34. Tuupanen S, et al. 2009. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat. Genet. 41:885- 890.
35. van der Flier LG, Clevers H. 2009. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71:241-260.
36. Wirtz S, Neufert C, Weigmann B, Neurath MF. 2007. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2:541- 556.
37. Wright JB, Brown SJ, Cole MD. 2010. Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated singlenucleotide polymorphism in colorectal cancer cells. Mol. Cell. Biol. 30: 1411-1420.
38. Yekkala K, Baudino TA. 2007. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. Mol. Cancer Res. 5:1296 -1303.
39. Yeung TM, Chia LA, Kosinski CM, Kuo CJ. 2011. Regulation of selfrenewal and differentiation by the intestinal stem cell niche. Cell. Mol. Life Sci. 68:2513-2523.
40. Yochum. 2011. Multiple Wnt/β-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS One e18966. doi:10.1371/journal.pone.0018966.
41. Yochum GS, Cleland R, Goodman RH. 2008. A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol. Cell. Biol. 28:7368 -7379.
42. Yochum GS, Cleland R, McWeeney S, Goodman RH. 2007. An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J. Biol. Chem. 282:871- 878.
43. Yochum GS, et al. 2007. Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 104:3324 -3329.
44. Yochum GS, Sherrick CM, Macpartlin M, Goodman RH. 2010. A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5'and 3'Wnt responsive enhancers. Proc. Natl. Acad. Sci. U. S. A. 107:145-150.