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Volumn 58, Issue , 2012, Pages 405-417

Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines

(6) Secci, Daniela a Bolasco, Adriana a Carradori, Simone a D'Ascenzio, Melissa a Nescatelli, Riccardo a Yáñez, Matilde b

a SAPIENZA UNIVERSITY OF ROME (Italy)

b UNIVERSITY OF SANTIAGO DE COMPOSTELA (Spain)

Author keywords

Hantzsch reaction; Hydrazone; Monoamine oxidase inhibitors; Selective hMAO B inhibitors; Thiazole

Indexed keywords

1 (1 PHENYLETHYLIDENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (BENZODIOXOL 5 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (FURAN 2 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (NAPHTHALEN 1 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (NAPHTHALEN 1 YLMETHYLENE) 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (PYRIDIN 3 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (PYRIDIN 3 YLMETHYLENE) 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (PYRIDIN 4 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (THIOPHEN 2 YLMETHYLENE) 2 [4 (4 CYANOPHENYL)THIAZOL-2 YL]HYDRAZINE; 1 (THIOPHEN 2 YLMETHYLENE) 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (1H INDOL 3 YL)METHYLENE] 2 [4 (4 CYANOPHENYL)HIAZOL 2 YL]HYDRAZINE; 1 [1 (2 OXO 2H CHROMEN 3 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (FURAN 2 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (FURAN 2 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (NAPHTHALEN 2 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (NAPHTHALEN 2 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 2 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 2 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 3 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 3 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 4 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (PYRIDIN 4 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (THIOPHEN 2 YL)ETHYLIDENE] 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 [1 (THIOPHEN 2 YL)ETHYLIDENE] 2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZINE; 2 (THIAZOL 2 YL)ETHYLIDENE 2 [4 (4 CYANOPHENYL)THIAZOL 2 YL]HYDRAZINE; CARBON; HYDRAZINE DERIVATIVE; MONOAMINE OXIDASE B INHIBITOR; THIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; ELECTRON; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDRAZINES; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868676600 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.10.032 Document Type: Article

Times cited : (44)

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