-
1
-
-
33644878356
-
Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks
-
Aguilar M. Hart R. (2005) Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks. Cochrane Database Syst Rev CD001925.
-
(2005)
Cochrane Database Syst Rev
, pp. CD001925
-
-
Aguilar, M.1
Hart, R.2
-
2
-
-
0033608466
-
Association of polymorphisms in the cytochrome P 450 Cyp2c9 with warfarin dose requirement and risk of bleeding complications
-
Aithal G.P. Day C.P. Kesteven P.J. Daly A.K. (1999) Association of polymorphisms in the cytochrome P 450 Cyp2c9 with warfarin dose requirement and risk of bleeding complications. Lancet 353: 717–719.
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
3
-
-
38749131205
-
The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
-
Blech S. Ebner T. Ludwig-Schwellinger E. Stangier J. Roth W. (2008) The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 36: 386–399.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 386-399
-
-
Blech, S.1
Ebner, T.2
Ludwig-Schwellinger, E.3
Stangier, J.4
Roth, W.5
-
4
-
-
33744945247
-
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE W): a randomised controlled trial
-
Connolly S. Pogue J. Hart R. Pfeffer M. Hohnloser S. Chrolavicius S. et al. (2006) Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE W): a randomised controlled trial. Lancet 367: 1903–1912.
-
(2006)
Lancet
, vol.367
, pp. 1903-1912
-
-
Connolly, S.1
Pogue, J.2
Hart, R.3
Pfeffer, M.4
Hohnloser, S.5
Chrolavicius, S.6
-
9
-
-
57149140461
-
Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
-
Connolly S.J. Pogue J. Eikelboom J. Flaker G. Commerford P. Franzosi M.G. et al. (2008) Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range. Circulation 118: 2029–2037.
-
(2008)
Circulation
, vol.118
, pp. 2029-2037
-
-
Connolly, S.J.1
Pogue, J.2
Eikelboom, J.3
Flaker, G.4
Commerford, P.5
Franzosi, M.G.6
-
11
-
-
70349675634
-
Improved oral anticoagulation after a dietary vitamin K-guided strategy: a randomized controlled trial
-
following
-
de Assis M.C. Rabelo E.R. Avila C.W. Polanczyk C.A. Rohde L.E. (2009) Improved oral anticoagulation after a dietary vitamin K-guided strategy: a randomized controlled trial. Circulation 120: 1115-1122, 1113 p following 1122.
-
(2009)
Circulation
, vol.120
, pp. 1115-1122
-
-
de Assis, M.C.1
Rabelo, E.R.2
Avila, C.W.3
Polanczyk, C.A.4
Rohde, L.E.5
-
12
-
-
78349313002
-
Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial
-
Diener H.-C. Connolly S.J. Ezekowitz M.D. Wallentin L. Reilly P.A. Yang S. et al. (2010) Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol 9: 1157–1163.
-
(2010)
Lancet Neurol
, vol.9
, pp. 1157-1163
-
-
Diener, H.-C.1
Connolly, S.J.2
Ezekowitz, M.D.3
Wallentin, L.4
Reilly, P.A.5
Yang, S.6
-
13
-
-
80053571188
-
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
-
Eerenberg E.S. Kamphuisen P.W. Sijpkens M.K. Meijers J.C. Buller H.R. Levi M. (2011) Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 124: 1573–1579.
-
(2011)
Circulation
, vol.124
, pp. 1573-1579
-
-
Eerenberg, E.S.1
Kamphuisen, P.W.2
Sijpkens, M.K.3
Meijers, J.C.4
Buller, H.R.5
Levi, M.6
-
14
-
-
57449094606
-
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
-
Eriksson B.I. Quinlan D.J. Weitz J.I. (2009) Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet 48: 1–22.
-
(2009)
Clin Pharmacokinet
, vol.48
, pp. 1-22
-
-
Eriksson, B.I.1
Quinlan, D.J.2
Weitz, J.I.3
-
16
-
-
84868631199
-
A Randomized Clinical Trial of Three Doses of a Long-Acting Oral Direct Factor Xa Inhibitor Betrixaban in Patients with Atrial Fibrillation (Explore-Xa)
-
Available at (accessed 21 October 2011).
-
Ezekowitz M. (2010) A Randomized Clinical Trial of Three Doses of a Long-Acting Oral Direct Factor Xa Inhibitor Betrixaban in Patients with Atrial Fibrillation (Explore-Xa). Available at: http://www.cardiosource.org/Science-And-Quality/Clinical-Trials/E/EXPLOREXa.aspx. (accessed 21 October 2011).
-
(2010)
-
-
Ezekowitz, M.1
-
17
-
-
0026478818
-
Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators
-
Ezekowitz M.D. Bridgers S.L. James K.E. Carliner N.H. Colling C.L. Gornick C.C. et al. (1992) Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators. N Engl J Med 327: 1406–1412.
-
(1992)
N Engl J Med
, vol.327
, pp. 1406-1412
-
-
Ezekowitz, M.D.1
Bridgers, S.L.2
James, K.E.3
Carliner, N.H.4
Colling, C.L.5
Gornick, C.C.6
-
18
-
-
35348879239
-
Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (Petro Study)
-
Ezekowitz M.D. Reilly P.A. Nehmiz G. Simmers T.A. Nagarakanti R. Parcham-Azad K. et al. (2007) Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (Petro Study). Am J Cardiol 100: 1419–1426.
-
(2007)
Am J Cardiol
, vol.100
, pp. 1419-1426
-
-
Ezekowitz, M.D.1
Reilly, P.A.2
Nehmiz, G.3
Simmers, T.A.4
Nagarakanti, R.5
Parcham-Azad, K.6
-
19
-
-
0346496571
-
National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation
-
Fang M.C. Stafford R.S. Ruskin J.N. Singer D.E. (2004) National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation. Arch Intern Med 164: 55–60.
-
(2004)
Arch Intern Med
, vol.164
, pp. 55-60
-
-
Fang, M.C.1
Stafford, R.S.2
Ruskin, J.N.3
Singer, D.E.4
-
20
-
-
2342506587
-
Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols
-
Franco V. Polanczyk C.A. Clausell N. Rohde L.E. (2004) Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols. Am J Med 116: 651–656.
-
(2004)
Am J Med
, vol.116
, pp. 651-656
-
-
Franco, V.1
Polanczyk, C.A.2
Clausell, N.3
Rohde, L.E.4
-
21
-
-
79551589662
-
Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
-
Freeman J.V. Zhu R.P. Owens D.K. Garber A.M. Hutton D.W. Go A.S. et al. (2010) Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann Intern Med 154: 1–11.
-
(2010)
Ann Intern Med
, vol.154
, pp. 1-11
-
-
Freeman, J.V.1
Zhu, R.P.2
Owens, D.K.3
Garber, A.M.4
Hutton, D.W.5
Go, A.S.6
-
23
-
-
70349306850
-
Can we rely on RE-LY?
-
Gage B.F. (2009) Can we rely on RE-LY? N Engl J Med 361: 1200–1202.
-
(2009)
N Engl J Med
, vol.361
, pp. 1200-1202
-
-
Gage, B.F.1
-
24
-
-
0035854054
-
Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
-
Gage B.F. Waterman A.D. Shannon W. Boechler M. Rich M.W. Radford M.J. (2001) Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 285: 2864–2870.
-
(2001)
JAMA
, vol.285
, pp. 2864-2870
-
-
Gage, B.F.1
Waterman, A.D.2
Shannon, W.3
Boechler, M.4
Rich, M.W.5
Radford, M.J.6
-
25
-
-
60549096887
-
Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated
-
Gladstone D.J. Bui E. Fang J. Laupacis A. Lindsay M.P. Tu J.V. et al. (2009) Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated. Stroke 40: 235–240.
-
(2009)
Stroke
, vol.40
, pp. 235-240
-
-
Gladstone, D.J.1
Bui, E.2
Fang, J.3
Laupacis, A.4
Lindsay, M.P.5
Tu, J.V.6
-
26
-
-
0344861847
-
Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice?
-
Go A.S. Hylek E.M. Chang Y. Phillips K.A. Henault L.E. Capra A.M. et al. (2003) Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice? JAMA 290: 2685–2692.
-
(2003)
JAMA
, vol.290
, pp. 2685-2692
-
-
Go, A.S.1
Hylek, E.M.2
Chang, Y.3
Phillips, K.A.4
Henault, L.E.5
Capra, A.M.6
-
29
-
-
77649093748
-
Effect of hepatic impairment on the pharmacokinetics, pharmacodynamics and tolerability of rivaroxaban – an oral, direct factor Xa inhibitor
-
Halabi A. Kubitza D. Zuehlsdorf M. Becka M. Mueck W. Maatouk H. (2007) Effect of hepatic impairment on the pharmacokinetics, pharmacodynamics and tolerability of rivaroxaban – an oral, direct factor Xa inhibitor. J Thromb Haemost 5: P-M-635.
-
(2007)
J Thromb Haemost
, vol.5
, pp. P-M-635
-
-
Halabi, A.1
Kubitza, D.2
Zuehlsdorf, M.3
Becka, M.4
Mueck, W.5
Maatouk, H.6
-
30
-
-
77949918794
-
Anticoagulant self-management using near patient testing and decision support software provided via an internet website improved anticoagulant control in patients on long-term warfarin
-
Harper P.L. Pollock D. (2008) Anticoagulant self-management using near patient testing and decision support software provided via an internet website improved anticoagulant control in patients on long-term warfarin. ASH Annual Meeting Abstracts 112: 1278–.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 1278
-
-
Harper, P.L.1
Pollock, D.2
-
31
-
-
34347394385
-
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
-
Hart R.G. Pearce L.A. Aguilar M.I. (2007) Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 146: 857–867.
-
(2007)
Ann Intern Med
, vol.146
, pp. 857-867
-
-
Hart, R.G.1
Pearce, L.A.2
Aguilar, M.I.3
-
32
-
-
33646459330
-
The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement
-
Herman D. Peternel P. Stegnar M. Breskvar K. Dolzan V. (2006) The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement. Thromb Haemost 95: 782–787.
-
(2006)
Thromb Haemost
, vol.95
, pp. 782-787
-
-
Herman, D.1
Peternel, P.2
Stegnar, M.3
Breskvar, K.4
Dolzan, V.5
-
35
-
-
15844410955
-
Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British population
-
Jones M. Mcewan P. Morgan C.L. Peters J.R. Goodfellow J. Currie C.J. (2005) Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British population. Heart 91: 472–477.
-
(2005)
Heart
, vol.91
, pp. 472-477
-
-
Jones, M.1
Mcewan, P.2
Morgan, C.L.3
Peters, J.R.4
Goodfellow, J.5
Currie, C.J.6
-
36
-
-
34548319482
-
Drug interactions with warfarin: what clinicians need to know
-
Juurlink D.N. (2007) Drug interactions with warfarin: what clinicians need to know. CMAJ 177: 369–371.
-
(2007)
CMAJ
, vol.177
, pp. 369-371
-
-
Juurlink, D.N.1
-
37
-
-
0842308834
-
Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin
-
Khan T. Wynne H. Wood P. Torrance A. Hankey C. Avery P. et al. (2004) Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin. Br J Haematol 124: 348–354.
-
(2004)
Br J Haematol
, vol.124
, pp. 348-354
-
-
Khan, T.1
Wynne, H.2
Wood, P.3
Torrance, A.4
Hankey, C.5
Avery, P.6
-
38
-
-
78649289929
-
Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct factor Xa inhibitor
-
Kubitza D. Becka M. Mueck W. Halabi A. Maatouk H. Klause N. et al. (2010) Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct factor Xa inhibitor. Br J Clin Pharmacol 70: 703–712.
-
(2010)
Br J Clin Pharmacol
, vol.70
, pp. 703-712
-
-
Kubitza, D.1
Becka, M.2
Mueck, W.3
Halabi, A.4
Maatouk, H.5
Klause, N.6
-
39
-
-
55549139511
-
Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
-
Kubitza D. Becka M. Roth A. Mueck W. (2008) Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects. Curr Med Res Opin 24: 2757–2765.
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 2757-2765
-
-
Kubitza, D.1
Becka, M.2
Roth, A.3
Mueck, W.4
-
40
-
-
29144518504
-
Safety, pharmacodynamics, and pharmacokinetics of Bay 59-7939--an oral, direct factor Xa inhibitor--after multiple dosing in healthy male subjects
-
Kubitza D. Becka M. Wensing G. Voith B. Zuehlsdorf M. (2005) Safety, pharmacodynamics, and pharmacokinetics of Bay 59-7939--an oral, direct factor Xa inhibitor--after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 61: 873–880.
-
(2005)
Eur J Clin Pharmacol
, vol.61
, pp. 873-880
-
-
Kubitza, D.1
Becka, M.2
Wensing, G.3
Voith, B.4
Zuehlsdorf, M.5
-
41
-
-
33846448135
-
Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (Bay 59-7939) in healthy subjects
-
Kubitza D. Becka M. Zuehlsdorf M. Mueck W. (2007) Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (Bay 59-7939) in healthy subjects. J Clin Pharmacol 47: 218–226.
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 218-226
-
-
Kubitza, D.1
Becka, M.2
Zuehlsdorf, M.3
Mueck, W.4
-
42
-
-
9144262426
-
Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial
-
Kurnik D. Loebstein R. Rabinovitz H. Austerweil N. Halkin H. Almog S. (2004) Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial. Thromb Haemost 92: 1018–1024.
-
(2004)
Thromb Haemost
, vol.92
, pp. 1018-1024
-
-
Kurnik, D.1
Loebstein, R.2
Rabinovitz, H.3
Austerweil, N.4
Halkin, H.5
Almog, S.6
-
43
-
-
0035889154
-
Genetic polymorphism in exon 4 of cytochrome P 450 Cyp2c9 may be associated with warfarin sensitivity in Chinese patients
-
Leung A.Y. Chow H.C. Kwong Y.L. Lie A.K. Fung A.T. Chow W.H. et al. (2001) Genetic polymorphism in exon 4 of cytochrome P 450 Cyp2c9 may be associated with warfarin sensitivity in Chinese patients. Blood 98: 2584–2587.
-
(2001)
Blood
, vol.98
, pp. 2584-2587
-
-
Leung, A.Y.1
Chow, H.C.2
Kwong, Y.L.3
Lie, A.K.4
Fung, A.T.5
Chow, W.H.6
-
44
-
-
33750023407
-
Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis
-
Liesenfeld K.H. Schafer H.G. Troconiz I.F. Tillmann C. Eriksson B.I. Stangier J. (2006) Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis. Br J Clin Pharmacol 62: 527–537.
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 527-537
-
-
Liesenfeld, K.H.1
Schafer, H.G.2
Troconiz, I.F.3
Tillmann, C.4
Eriksson, B.I.5
Stangier, J.6
-
46
-
-
65349153112
-
The role of tissue factor and factor VIIa in hemostasis
-
Mackman N. (2009) The role of tissue factor and factor VIIa in hemostasis. Anesth Analg 108: 1447–1452.
-
(2009)
Anesth Analg
, vol.108
, pp. 1447-1452
-
-
Mackman, N.1
-
47
-
-
34547693119
-
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
-
Mant J. Hobbs F.D. Fletcher K. Roalfe A. Fitzmaurice D. Lip G.Y. et al. (2007) Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet 370: 493–503.
-
(2007)
Lancet
, vol.370
, pp. 493-503
-
-
Mant, J.1
Hobbs, F.D.2
Fletcher, K.3
Roalfe, A.4
Fitzmaurice, D.5
Lip, G.Y.6
-
48
-
-
20444395760
-
Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study
-
Marini C. de Santis F. Sacco S. Russo T. Olivieri L. Totaro R. et al. (2005) Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke 36: 1115–1119.
-
(2005)
Stroke
, vol.36
, pp. 1115-1119
-
-
Marini, C.1
de Santis, F.2
Sacco, S.3
Russo, T.4
Olivieri, L.5
Totaro, R.6
-
49
-
-
0036066718
-
Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial
-
Matchar D.B. Samsa G.P. Cohen S.J. Oddone E.Z. Jurgelski A.E. (2002) Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am J Med 113: 42–51.
-
(2002)
Am J Med
, vol.113
, pp. 42-51
-
-
Matchar, D.B.1
Samsa, G.P.2
Cohen, S.J.3
Oddone, E.Z.4
Jurgelski, A.E.5
-
50
-
-
48949105694
-
An analysis of the relative effects of Vkorc 1 and Cyp2c9 variants on anticoagulation related outcomes in warfarin-treated patients
-
Meckley L.M. Wittkowsky A.K. Rieder M.J. Rettie A.E. Veenstra D.L. (2008) An analysis of the relative effects of Vkorc 1 and Cyp2c9 variants on anticoagulation related outcomes in warfarin-treated patients. Thromb Haemost 100: 229–239.
-
(2008)
Thromb Haemost
, vol.100
, pp. 229-239
-
-
Meckley, L.M.1
Wittkowsky, A.K.2
Rieder, M.J.3
Rettie, A.E.4
Veenstra, D.L.5
-
51
-
-
33747052359
-
Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
-
Miyasaka Y. Barnes M.E. Gersh B.J. Cha S.S. Bailey K.R. Abhayaratna W.P. et al. (2006) Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 114: 119–125.
-
(2006)
Circulation
, vol.114
, pp. 119-125
-
-
Miyasaka, Y.1
Barnes, M.E.2
Gersh, B.J.3
Cha, S.S.4
Bailey, K.R.5
Abhayaratna, W.P.6
-
52
-
-
78751637313
-
Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion
-
Nagarakanti R. Ezekowitz M.D. Oldgren J. Yang S. Chernick M. Aikens T.H. et al. (2011) Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion. Circulation 123: 131–136.
-
(2011)
Circulation
, vol.123
, pp. 131-136
-
-
Nagarakanti, R.1
Ezekowitz, M.D.2
Oldgren, J.3
Yang, S.4
Chernick, M.5
Aikens, T.H.6
-
53
-
-
0014314758
-
Studies on coumarin anticoagulant drugs. initiation of warfarin therapy without a loading dose
-
O'reilly R.A. Aggeler P.M. (1968) Studies on coumarin anticoagulant drugs. initiation of warfarin therapy without a loading dose. Circulation 38: 169–177.
-
(1968)
Circulation
, vol.38
, pp. 169-177
-
-
O'reilly, R.A.1
Aggeler, P.M.2
-
54
-
-
77953787643
-
Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
-
Ogata K. Mendell-Harary J. Tachibana M. Masumoto H. Oguma T. Kojima M. et al. (2010) Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol 50: 743–753.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 743-753
-
-
Ogata, K.1
Mendell-Harary, J.2
Tachibana, M.3
Masumoto, H.4
Oguma, T.5
Kojima, M.6
-
55
-
-
78649998684
-
Dabigatran etexilate versus warfarin in atrial fibrillation patients with low, moderate and high CHADS 2 score – a RE-LY subgroup analysis
-
Oldgren J. Alings M. Darius H. Eikelboom J. Ezekowitz M. Parekh A. et al. (2010) Dabigatran etexilate versus warfarin in atrial fibrillation patients with low, moderate and high CHADS 2 score – a RE-LY subgroup analysis. J Am Coll Cardiol 55: A1.E2.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. A1.E2
-
-
Oldgren, J.1
Alings, M.2
Darius, H.3
Eikelboom, J.4
Ezekowitz, M.5
Parekh, A.6
-
57
-
-
0024543543
-
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen Afasak Study
-
Petersen P. Boysen G. Godtfredsen J. Andersen E.D. Andersen B. (1989) Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen Afasak Study. Lancet 1: 175–179.
-
(1989)
Lancet
, vol.1
, pp. 175-179
-
-
Petersen, P.1
Boysen, G.2
Godtfredsen, J.3
Andersen, E.D.4
Andersen, B.5
-
59
-
-
79751531393
-
Heart disease and stroke statistics--2011 update: a report from the American Heart Association
-
Roger V.L. Go A.S. Lloyd-Jones D.M. Adams R.J. Berry J.D. Brown T.M. et al. (2011) Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation 123: e18–e209.
-
(2011)
Circulation
, vol.123
, pp. e18-e209
-
-
Roger, V.L.1
Go, A.S.2
Lloyd-Jones, D.M.3
Adams, R.J.4
Berry, J.D.5
Brown, T.M.6
-
61
-
-
77957932391
-
Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48)
-
Ruff C.T. Giugliano R.P. Antman E.M. Crugnale S.E. Bocanegra T. Mercuri M. et al. (2010) Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J 160: 635–641.
-
(2010)
Am Heart J
, vol.160
, pp. 635-641
-
-
Ruff, C.T.1
Giugliano, R.P.2
Antman, E.M.3
Crugnale, S.E.4
Bocanegra, T.5
Mercuri, M.6
-
62
-
-
84868650749
-
Randomized controlled trial of supervised patient self-testing of warfarin therapy using an internet based expert system
-
Ryan F. Byrne S. O'shea S. (2008) Randomized controlled trial of supervised patient self-testing of warfarin therapy using an internet based expert system. ASH Annual Meeting Abstracts 112: 879.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 879
-
-
Ryan, F.1
Byrne, S.2
O'shea, S.3
-
63
-
-
67949094412
-
Randomized controlled trial of supervised patient self-testing of warfarin therapy using an internet-based expert system
-
Ryan F. Byrne S. O'shea S. (2009) Randomized controlled trial of supervised patient self-testing of warfarin therapy using an internet-based expert system. J Thromb Haemost 7: 1284–1290.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 1284-1290
-
-
Ryan, F.1
Byrne, S.2
O'shea, S.3
-
64
-
-
7244258903
-
Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
-
Schurgers L.J. Shearer M.J. Hamulyak K. Stocklin E. Vermeer C. (2004) Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects. Blood 104: 2682–2689.
-
(2004)
Blood
, vol.104
, pp. 2682-2689
-
-
Schurgers, L.J.1
Shearer, M.J.2
Hamulyak, K.3
Stocklin, E.4
Vermeer, C.5
-
65
-
-
45949095568
-
Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
-
Singer D.E. Albers G.W. Dalen J.E. Fang M.C. Go A.S. Halperin J.L. et al. (2008) Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133: 546S–592S.
-
(2008)
Chest
, vol.133
, pp. 546S-592S
-
-
Singer, D.E.1
Albers, G.W.2
Dalen, J.E.3
Fang, M.C.4
Go, A.S.5
Halperin, J.L.6
-
66
-
-
79955774273
-
Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: A Canadian Payer Perspective
-
in press
-
Sorensen S.V. Kansal A.R. Connolly S. Peng S. Linnehan J. Bradley-Kennedy C. et al. (2011) Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: A Canadian Payer Perspective. Thromb Haemost 105, in press.
-
(2011)
Thromb Haemost
, vol.105
-
-
Sorensen, S.V.1
Kansal, A.R.2
Connolly, S.3
Peng, S.4
Linnehan, J.5
Bradley-Kennedy, C.6
-
67
-
-
41949116970
-
Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
-
Stangier J. (2008) Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 47: 285–295.
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 285-295
-
-
Stangier, J.1
-
68
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J. Rathgen K. Stahle H. Gansser D. Roth W. (2007) The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 64: 292–303.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Gansser, D.4
Roth, W.5
-
69
-
-
77949421739
-
Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study
-
Stangier J. Rathgen K. Stahle H. Mazur D. (2010) Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 49: 259–268.
-
(2010)
Clin Pharmacokinet
, vol.49
, pp. 259-268
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Mazur, D.4
-
70
-
-
37149005153
-
Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
-
Stangier J. Stahle H. Rathgen K. Fuhr R. (2008) Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 47: 47–59.
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 47-59
-
-
Stangier, J.1
Stahle, H.2
Rathgen, K.3
Fuhr, R.4
-
71
-
-
2942696888
-
Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study
-
Stroke Prevention in Atrial Fibrillation II: Study Investigators
-
Stroke Prevention in Atrial Fibrillation II Study Investigators (1994) Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet 343: 687–691.
-
(1994)
Lancet
, vol.343
, pp. 687-691
-
-
-
72
-
-
0025914693
-
Stroke Prevention in Atrial Fibrillation Study. Final Results
-
Stroke Prevention in Atrial Fibrillation Study Investigators
-
Stroke Prevention in Atrial Fibrillation Study Investigators (1991) Stroke Prevention in Atrial Fibrillation Study. Final Results. Circulation 84: 527–539.
-
(1991)
Circulation
, vol.84
, pp. 527-539
-
-
-
73
-
-
0034283762
-
Influence of cytochrome P-450 Cyp2c9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
-
Taube J. Halsall D. Baglin T. (2000) Influence of cytochrome P-450 Cyp2c9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood 96: 1816–1819.
-
(2000)
Blood
, vol.96
, pp. 1816-1819
-
-
Taube, J.1
Halsall, D.2
Baglin, T.3
-
74
-
-
0025241137
-
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation
-
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators
-
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators (1990) The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med 323: 1505–1511.
-
(1990)
N Engl J Med
, vol.323
, pp. 1505-1511
-
-
-
75
-
-
0029070127
-
Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia
-
The European Atrial Fibrillation Trial Study Group
-
The European Atrial Fibrillation Trial Study Group (1995) Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. N Engl J Med 333: 5–10.
-
(1995)
N Engl J Med
, vol.333
, pp. 5-10
-
-
-
76
-
-
77953168824
-
Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
-
van Ryn J. Stangier J. Haertter S. Liesenfeld K.H. Wienen W. Feuring M. et al. (2010) Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 103: 1116–1127.
-
(2010)
Thromb Haemost
, vol.103
, pp. 1116-1127
-
-
van Ryn, J.1
Stangier, J.2
Haertter, S.3
Liesenfeld, K.H.4
Wienen, W.5
Feuring, M.6
-
77
-
-
33645547905
-
Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin
-
Vecsler M. Loebstein R. Almog S. Kurnik D. Goldman B. Halkin H. et al. (2006) Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin. Thromb Haemost 95: 205–211.
-
(2006)
Thromb Haemost
, vol.95
, pp. 205-211
-
-
Vecsler, M.1
Loebstein, R.2
Almog, S.3
Kurnik, D.4
Goldman, B.5
Halkin, H.6
-
78
-
-
33745243376
-
Early detection of patients with a poor response to vitamin K antagonists: the clinical impact of individual time within target range in patients with heart disease
-
Veeger N.J.G.M. Piersma-Wichers M. Hillege H.L. Crijns H.J.G.M. van der Meer J. (2006) Early detection of patients with a poor response to vitamin K antagonists: the clinical impact of individual time within target range in patients with heart disease. J Thrombosis Haemostasis 4: 1625–1627.
-
(2006)
J Thrombosis Haemostasis
, vol.4
, pp. 1625-1627
-
-
Veeger, N.J.G.M.1
Piersma-Wichers, M.2
Hillege, H.L.3
Crijns, H.J.G.M.4
van der Meer, J.5
-
79
-
-
77952737706
-
Drug and dietary interactions of the new and emerging oral anticoagulants
-
Walenga J.M. Adiguzel C. (2010) Drug and dietary interactions of the new and emerging oral anticoagulants. Int J Clin Pract 64: 956–967.
-
(2010)
Int J Clin Pract
, vol.64
, pp. 956-967
-
-
Walenga, J.M.1
Adiguzel, C.2
-
80
-
-
77956977472
-
Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial
-
Wallentin L. Yusuf S. Ezekowitz M.D. Alings M. Flather M. Franzosi M.G. et al. (2010) Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet 376: 975–983.
-
(2010)
Lancet
, vol.376
, pp. 975-983
-
-
Wallentin, L.1
Yusuf, S.2
Ezekowitz, M.D.3
Alings, M.4
Flather, M.5
Franzosi, M.G.6
-
81
-
-
76749166335
-
In vitro assessment of metabolic drug–drug interaction potential of apixaban through cytochrome P 450 phenotyping, inhibition, and induction studies
-
Wang L. Zhang D. Raghavan N. Yao M. Ma L. Frost C.E. et al. (2010) In vitro assessment of metabolic drug–drug interaction potential of apixaban through cytochrome P 450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 38: 448–458.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 448-458
-
-
Wang, L.1
Zhang, D.2
Raghavan, N.3
Yao, M.4
Ma, L.5
Frost, C.E.6
-
82
-
-
79953066921
-
2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation / American Heart Association Task Force on Practice Guidelines
-
Wann L.S. Curtis A.B. Ellenbogen K.A. Estes N.a.M. Ezekowitz M.D. Jackman W.M. et al. (2011) 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation / American Heart Association Task Force on Practice Guidelines. Circulation:
-
(2011)
Circulation
-
-
Wann, L.S.1
Curtis, A.B.2
Ellenbogen, K.A.3
Estes, N.a.M.4
Ezekowitz, M.D.5
Jackman, W.M.6
-
83
-
-
66449099711
-
Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
-
Weinz C. Schwarz T. Kubitza D. Mueck W. Lang D. (2009) Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans. Drug Metab Dispos 37: 1056–1064.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1056-1064
-
-
Weinz, C.1
Schwarz, T.2
Kubitza, D.3
Mueck, W.4
Lang, D.5
-
84
-
-
77954361232
-
Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation
-
Weitz J.I. Connolly S.J. Patel I. Salazar D. Rohatagi S. Mendell J. et al. (2010) Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation. Thromb Haemost 104: 633–641.
-
(2010)
Thromb Haemost
, vol.104
, pp. 633-641
-
-
Weitz, J.I.1
Connolly, S.J.2
Patel, I.3
Salazar, D.4
Rohatagi, S.5
Mendell, J.6
-
85
-
-
33847006936
-
Comparison of outcomes among patients randomized to warfarin therapy according to anticoagulant control: results from SPORTIF III and V
-
White H.D. Gruber M. Feyzi J. Kaatz S. Tse H.F. Husted S. et al. (2007) Comparison of outcomes among patients randomized to warfarin therapy according to anticoagulant control: results from SPORTIF III and V. Arch Intern Med 167: 239–245.
-
(2007)
Arch Intern Med
, vol.167
, pp. 239-245
-
-
White, H.D.1
Gruber, M.2
Feyzi, J.3
Kaatz, S.4
Tse, H.F.5
Husted, S.6
-
87
-
-
0025779484
-
Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
-
Wolf P.A. Abbott R.D. Kannel W.B. (1991) Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 22: 983–988.
-
(1991)
Stroke
, vol.22
, pp. 983-988
-
-
Wolf, P.A.1
Abbott, R.D.2
Kannel, W.B.3
-
88
-
-
63149141508
-
Discovery of betrixaban (Prt054021), N-(5-chloropyridin-2-Yl)-2-(4-(N, N-dimethylcarbamimidoyl) benzamido)-5-meth oxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
-
Zhang P. Huang W. Wang L. Bao L. Jia Z.J. Bauer S.M. et al. (2009) Discovery of betrixaban (Prt054021), N-(5-chloropyridin-2-Yl)-2-(4-(N, N-dimethylcarbamimidoyl)benzamido)-5-meth oxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett 19: 2179–2185.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 2179-2185
-
-
Zhang, P.1
Huang, W.2
Wang, L.3
Bao, L.4
Jia, Z.J.5
Bauer, S.M.6
|