The Safety of Warfarin Therapy in the Nursing Home Setting

American Journal of Medicine

Volumn 120, Issue 6, 2007, Pages 539-544

  Gurwitz, Jerry H ^a,b   Field, Terry S ^a   Radford, Martha J ^c   Harrold, Leslie R ^a   Becker, Richard ^d   Reed, George ^a   DeBellis, Kristin ^a   Moldoff, Jason ^a   Verzier, Nancy ^e  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e QUALIDIGM   (United States)

Author keywords

Long term care; Medication safety; Nursing homes; Oral anticoagulants; Warfarin

Indexed keywords

WARFARIN;

AGED; ARTICLE; BRAIN HEMORRHAGE; CONJUNCTIVAL HEMORRHAGE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; DRUG SAFETY; EAR DISEASE; ECCHYMOSIS; EPISTAXIS; GASTROINTESTINAL HEMORRHAGE; GINGIVA BLEEDING; HEALTH CARE FACILITY; HEART ATRIUM FIBRILLATION; HEMATURIA; HEMOPTYSIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; INTRAOCULAR HEMORRHAGE; LUNG EMBOLISM; MEDICAL ERROR; NURSING HOME; PATIENT MONITORING; PHYSICIAN; PRESCRIPTION; PRIORITY JOURNAL; PROPHYLAXIS; STROKE; VAGINA BLEEDING;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; DRUG MONITORING; DRUG UTILIZATION; FEMALE; HEMORRHAGE; HOMES FOR THE AGED; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MEDICATION ERRORS; NURSING HOMES; WARFARIN;

EID: 34249037494     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.07.045     Document Type: Article

References (30)

1. McCormick D., Gurwitz J.H., Goldberg R.J., et al. Prevalence and quality of warfarin use for patients with atrial fibrillation in the long-term care setting. Arch Intern Med 161 (2001) 2458-2463
2. Gurwitz J.H., Monette J., Rochon P.A., Eckler M.A., and Avorn J. Atrial fibrillation and stroke prevention with warfarin in the long-term care setting. Arch Intern Med 157 (1997) 978-984
3. McCormick D., Gurwitz J.H., Goldberg R.J., and Ansell J. Long-term anticoagulation therapy for atrial fibrillation in elderly patients: efficacy, risk, and current patterns of use. J Thromb Thrombolysis 7 (1999) 157-163
4. Gurwitz J.H., Avorn J., Ross-Degnan D., Choodnovskiy I., and Ansell J. Aging and the anticoagulant response to warfarin therapy. Ann Intern Med 116 (1992) 901-904
5. Gurewich V. Ximelagatran-promises and concerns. JAMA 293 (2005) 736-739
6. Gurwitz J.H., Field T.S., Avorn J., et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med 109 (2000) 87-94
7. Gurwitz J.H., Field T.S., Judge J., et al. The incidence of adverse drug events in two large academic long-term care facilities. Am J Med 118 (2005) 251-258
8. Jones A. The National Nursing Home Survey: 1999 Summary. National Center for Health Statistics. Vital Health Stat 13 (2002) 152
9. Gurwitz J.H., Field T.S., Harrold L.R., et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 289 (2003) 1107-1116
10. Bates D.W., Cullen D.J., Laird N., et al., ADE Prevention Study Group. Incidence of adverse drug events and potential adverse drug events implications for prevention. JAMA 274 (1995) 29-34
11. Leape L.L., Bates D.W., Cullen D.J., et al. Systems analysis of adverse drug events. JAMA 274 (1995) 35-43
12. Leape L.L., Cullen D.J., Clapp M.D., et al. Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA 282 (1999) 267-270
13. Hylek E., and Singer D.E. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med 120 (1994) 897-902
14. Fang M.C., Chang Y., Hylek E.M., et al. Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med 141 (2004) 745-752
15. Kaushal R., Bates D.W., Landrigan C., et al. Medication errors and adverse drug events in pediatric in-patients. JAMA 285 (2001) 2114-2120
16. Bates D.W., Leape L.L., Cullen D.J., et al. Effect of computerized physician order entry and a team intervention on prevention on serious medication errors. JAMA 280 (1998) 1311-1316
17. Bates D.W., Spell N., Cullen J.J., et al. The costs of adverse drug events in hospitalized patients. JAMA 277 (1997) 307-311
18. Landefeld C.S., Anderson P.A., Goodnough L.T., et al. The bleeding severity index: Validation and comparison to other methods for classifying bleeding complications of medical therapy. J Clin Epidemiol 42 (1989) 711-718
19. White R.H., McKittrick T., Takakuwa J., Callahan C., McDonell M., Fihn S., and National Consortium of Anticoagulation Clinics. Management and prognosis of life-threatening bleeding during warfarin therapy. Arch Intern Med 156 (1996) 1197-1201
20. Freedman V.A., Martin L.G., and Schoeni R.F. Recent trends in disability and functioning among older adults in the United States: a systematic review. JAMA 288 (2002) 3137-3146
21. Sackett D.L., Haynes R.B., Guyatt G.H., and Tugwell P. Clinical Epidemiology: A Basic Science for Clinical Medicine. 2nd ed. (1991), Little Brown & Co, Boston, MA
22. Rosner B. Fundamentals of Biostatistics. 3rd ed. (1990), PWS-Kent, Boston, MA
23. Rosendaal F.R., Cannegieter S.C., van der Meer F.J.M., and Briet E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 69 (1993) 236-239
24. Rochon P.A., Field T.S., Bates D.W., et al. Clinical application of a computerized system for physician order entry with clinical decision support to prevent adverse drug events in long-term care. CMAJ 174 (2006) 52-54
25. Knight E.L., and Avorn J. Quality indicators for appropriate medication use in vulnerable elders. Ann Intern Med 135 (2001) 703-710
26. Matcher D.B., Samsa G.P., Cohen S.J., Oddone E.Z., and Gurgelski A.E. Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am J Med 113 (2002) 42-51
27. Harrold L.R., Gurwitz J.H., Tate J.P., et al. Physician attitudes concerning anticoagulation services in the long-term care setting. J Thromb Thromboylsis 14 (2002) 59-64
28. Rochon P.A., Field T.S., Bates D.W., et al. Computerized physician order entry with clinical decision support in the long-term care setting: Insights from the Baycrest Centre for Geriatric Care. J Am Geriatr Soc 53 (2005) 1780-1789
29. Hylek E.M., Go A.S., Chang Y., et al. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation. N Engl J Med 349 (2003) 1019-1026
30. SPORTIF Executive Steering Committee for the SPORTIF V Investigators. Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. A randomized trial. JAMA 293 (2005) 690-698