Characterization and functional analysis of the genes encoding 1-deoxy-d-xylulose-5-phosphate reductoisomerase and 1-deoxy-d-xylulose-5- phosphate synthase, the two enzymes in the MEP pathway, from Amomum villosum Lour

Molecular Biology Reports

Volumn 39, Issue 8, 2012, Pages 8287-8296

  Yang, Jinfen ^a   Adhikari, Megha Nath ^a   Liu, Hui ^a   Xu, Hui ^a   He, Guozhen ^a   Zhan, Ruoting ^a   Wei, Jieshu ^a   Chen, Weiwen ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

1 deoxy d xylulose 5 phosphate synthase; 1 deoxy d xylulose 5 phosphate reductoisomerase; Amomum villosum Lour.; Isoprenoid biosynthesis; Transgenic tobacco

Indexed keywords

1 DEOXY XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 1 DEOXY XYLULOSE 5 PHOSPHATE SYNTHASE; COMPLEMENTARY DNA; ESSENTIAL OIL; ISOPRENOID; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; 1 DEOXY D XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; 2 C METHYLERYTHRITOL 4 PHOSPHATE; 2-C-METHYLERYTHRITOL 4-PHOSPHATE; DEOXYXYLULOSE 5 PHOSPHATE SYNTHASE; DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE; DRUG DERIVATIVE; ERYTHRITOL; ISOMERASE; MULTIENZYME COMPLEX; OXIDOREDUCTASE; PIGMENT; SUGAR PHOSPHATE; TERPENE; TRANSFERASE;

AMINO ACID SEQUENCE; AMOMUM; AMOMUM VILLOSUM; ARTICLE; CHINA; CONTROLLED STUDY; DXR GENE; DXS GENE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE OVEREXPRESSION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOTOSYNTHETIC PIGMENT CONTENT; PLANT GENE; PLANT LEAF; PLANT PARAMETERS; PLANT ROOT; PLANT STEM; PLANT TISSUE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURAL BIOINFORMATICS; TOBACCO; ANTIBODY SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TRANSGENIC PLANT;

AMOMUM VILLOSUM; ESCHERICHIA COLI; NICOTIANA TABACUM;

ALDOSE-KETOSE ISOMERASES; AMOMUM; CLONING, MOLECULAR; ERYTHRITOL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, PLANT; METABOLIC NETWORKS AND PATHWAYS; MULTIENZYME COMPLEXES; ORGAN SPECIFICITY; OXIDOREDUCTASES; PIGMENTS, BIOLOGICAL; PLANTS, GENETICALLY MODIFIED; SUGAR PHOSPHATES; TERPENES; TOBACCO; TRANSFERASES;

EID: 84868645974     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1676-y     Document Type: Article

References (44)

1. Chinese Pharmacopoeia Commission (2005) Pharmacopoeia of People's Republic of China, vol I. People's Medical Publishing House, Beijing, p 80
2. Yu J, Sun L, Zhou L, Luo X, Guo J, Liu C, Cong P (1997) Chemical constituents of Fructus Amomi. Zhongguo Zhong Yao Za Zhi 22:231-232
3. Eisenreich W, Schwarz M, Cartayrade A, Arigoni D, Zenk MH, Bacher A (1998) The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. Chem Biol 5:R221-R233
4. Lichtenthaler HK (1999) The 1-deoxy-d-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annu Rev Plant Physiol Plant Mol Biol 50:47-66
5. Rohmer M (1999) The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat Prod Rep 16:565-574
6. Eisenreich W, Rohdich F, Bacher A (2001) Deoxyxylulose phosphate pathway to terpenoids. Trends Plant Sci 6:78-84
7. Shen G, Pang Y, Wu W, Liao Z, Zhao L, Sun X, Tang K (2006) Cloning and characterization of a root-specific expressing gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Ginkgo biloba. Mol Biol Rep 33(2):117-127
8. Mahmoud SS, Croteau RB (2001) Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase. Proc Nat Acad Sci USA 98:158915-158920
9. Estévez JM, Cantero A, Reindl A, Reichler S, León P (2001) 1-Deoxy-dxylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants. J Biol Chem 276:22901-22909
10. Zhang M, Li K, Zhang C, Gai J, Yu D (2009) Identification and characterization of class 1 DXS gene encoding 1-deoxy-d-xylulose-5-phosphate synthase, the first committed enzyme of the MEP pathway from soybean. Mol Biol Rep 36:879-887
11. Lange BM, Croteau RB (1999) Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: cloning and heterologous expression of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from peppermint. Arch Biochem Biophys 365:170-174
12. Carretero-Paulet L, Ahumada I, Cunillera N, Rodríguez- Concepción M, Ferrer A, Boronat A, Campos N (2002) Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-d-erythritol 4-phosphate pathway. Plant Physiol 129:1581-1591
13. Sprenger GA, Schörken U, Wiegert T, Grolle S, DeGraaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997) Identification of a thiamin-dependent synthesis in Escherichia coli required for the formation of the 1-deoxy-d-xylulose-5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proc Nat Acad Sci USA 94:12857-12862
14. Lange BM, Wildung MR, McCaskill D, Croteau R (1998) A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. Proc Nat Acad Sci USA 95:2100-2104
15. Khemvong S, Suvachittanont W (2005) Molecular cloning and expression of a cDNA encoding 1-deoxy-d-xylulose-5-phosphate synthase from oil palm Elaeis guineensis Jacq. Plant Sci 169:571-578
16. Wungsintaweekul J, Sirisuntipong T, Kongduang D, Losuphanporn T, Ounaroon A, Tansakul P, De-Eknamkul W (2008) Transcription profiles analysis of genes encoding 1-deoxy-d-xylulose 5-phosphate synthase and 2C-methyl-d-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus. Biol Pharm Bull 31:852-856
17. Hans J, Hause B, Strack D, Walter MH (2004) Cloning, characterization and immunolocalization of a mycorrhiza-inducible 1-deoxy-d-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize. Plant Physiol 134:614-624
18. Gong Y, Liao Z, Chen M, et al. (2005) Molecular cloning and characterization of a 1-deoxy-d-xylulose-5-phosphate reductoisomerase gene from Ginkgo biloba. DNA Seq 16:111-120
19. Wu SJ, Shi M, Wu JY (2009) Cloning and characterization of 1-deoxy-d-xylulose-5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza hairy roots. Biotechnol Appl Biochem 52:89-95
20. Yao H, Gong Y, Zuo K, et al. (2008) Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata. J Plant Physiol 165:203-213
21. Enfissi EM, Fraser PD, Lois LM, Boronat A, Schuch W, Bramley PM (2005) Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant Biotech J 3:17-27
22. Muñoz-Bertomeu J, Arrillaga I, Ros R, Segura J (2006) Up-regulation of 1-deoxy-d-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. Plant Physiol 142:890-900
23. Hasunuma T, Takeno S, Hayashi S, Sendai M, Bamba T, Yoshimura S, Tomizawa K, Fukusaki E, Miyake C (2008) Overexpression of 1-deoxy-d-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production. J Biosci Bioeng 105:518-526
24. Misawa N, Satomi Y, Kondo K, Yokoyama A, Kajiwara S, Saito T, Ohtani T, Miki W (1995) Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J Bacteriol 177:6575-6584
25. Zhang Y, Yang J, Lu S, Guo Z (2008) Overexpressing SgNCED1 in tobacco increases ABA level, antioxidant enzyme activities, and stress tolerance. J Plant Growth Regul 27:151-158
26. Lichtenthaler HK, Buschmann C (2001) Extraction of photosynthetic tissues: chlorophylls and carotenoids. In: Current protocols in food analytical chemistry. Wiley, Madison, pp F4.2.1-F4.2.6
27. Lichtenthaler HK, Buschmann C (2001) Chlorophylls and carotenoids: measurement and characterization by UV-VIS Spectroscopy. In: Wrolstad RE, Acree TE, An H (eds) Current protocols in food analytical chemistry. Wiley, New York, pp F4.3.1-F4.3.8
28. Takahashi S, Kuzuyama T, Watanabe H, Seto H (1998) A 1-deoxy-d-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-d-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Nat Acad Sci USA 95:9879-9884
29. Reuter K, Sanderbrand S, Jomaa H, Wiesner J, Steinbrecher I, Beck E, Hintz M, Klebe G, Stubbs M (2002) Crystal structure of 1-deoxy-d-xylulose-5- phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. J Biol Chem 277:5378-5384
30. Walter MH, Hans J, Strack D (2002) Two distantly related genes encoding 1-deoxy-d-xylulose 5-phosphate synthases: differential regulation in shoots and apocarotenoid-accumulating mycorrhizal roots. Plant J 31:243-254
31. Gavel Y, von Heijne G (1990) A conserved cleavage-site motif in chloroplast transit peptides. FEBS Lett 261:455-458
32. Xiang S, Usunow G, Lange G, Busch M, Tong L (2007) Crystal structure of 1-deoxy-d-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem 282:2676-2682
33. Querol J, Rodríguez-Concepción M, Boronat A, Imperial S (2001) Essential role of residue H49 for activity of Escherichia coli 1-deoxy-d xylulose-5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-d-erythritol-4-phosphate pathway for isoprenoid synthesis. Biochem Biophys Res Commun 289:155-160
34. Cuningham FX Jr, Gantt E (2000) Identification of multi-gene families encoding isopentenyl diphosphate isomerase in plants by heterologous complementation in Escherichia coli. Plant Cell Physiol 41:119-123
35. Matthews PD, Wurtzel ET (2000) Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase. Appl Microbiol Biotechnol 53:396-400
36. Cao X, Zong Z, Ju X, Sun Y, Dai C, Liu Q, Jiang J (2009) Molecular cloning, characterization and function analysis of the gene encoding HMG-CoA reductase from Euphorbia Pekinensis Rupr. Mol Biol Rep 37:1559-1567
37. Wang Y, Guo B, Zhang F, Yao H, Miao Z, Tang K (2007) Molecular cloning and functional analysis of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from hazel (Corylus avellana L. Gasaway). J Biochem Mol Biol 40:861-869
38. Liu W, Chen M, Yang C, Yang Y, Lan X, Liao Z (2009) A new 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase gene from Taxus media: cloning, characterization and functional complementation. J Med Plants Res 3:395-402
39. Estévez JM, Cantero A, Romero C, Kawaide H, Jiménez LF, Kuzuyama T, Seto H, Kamiya Y, León P (2000) Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-d-erythritol-4-phosphate pathway in Arabidopsis. Plant Physiol 124:95-103
40. Schwender J, Seemann M, Lichtenthaler HK, Rohmer M (1996) Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus. Biochem J 316:73-80
41. Eisenreich W, Sagner S, Zenk MH, Bacher A (1997) Monoterpenoid essential oils are not of mevalonoid origin. Tetrahedron Lett 38:3889-3892
42. Guo H, Pei X, Wan F, Cheng H (2010) Molecular cloning of allelopathy related genes and their relation to HHO in Eupatorium adenophorum. Mol Biol Rep 38:4651-4656
43. Lois LM, Rodríguez-Concepción M, Gallego F, Campos N, Boronat A (2000) Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-d-xylulose 5-phosphate synthase. Plant J 22:503-513
44. Paetzold H, Garms S, Bartram S, et al. (2010) The isogene 1-deoxy-d-xylulose 5-phosphate synthase 2 controls isoprenoid profiles, precursor pathway allocation, and density of tomato trichomes. Mol Plant 3:904-906