Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: A principal component analysis approach

BMC Cardiovascular Disorders

Volumn 12, Issue , 2012, Pages

  Panazzolo, Diogo G ^a   Sicuro, Fernando L ^a   Clapauch, Ruth ^a,b   Maranhão, Priscila A ^a   Bouskela, Eliete ^a   Kraemer Aguiar, Luiz G ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL DA LAGOA   (Brazil)

Author keywords

Capillaries; Impaired fasting glucose; Metabolic syndrome; Microcirculation; Obesity; Principal component analysis

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; BODY MASS; CAPILLAROSCOPY; CAPILLARY DENSITY; CELLULAR PARAMETERS; CHILD; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MICROANGIOPATHY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RED BLOOD CELL VELOCITY; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

ADOLESCENT; ADULT; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CAPILLARIES; CHILD; FASTING; FEMALE; HUMANS; LIPIDS; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PRINCIPAL COMPONENT ANALYSIS;

EID: 84868635242     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-12-102     Document Type: Article

References (39)

1. Stubbs PJ, Alaghband-Zadeh J, Laycock JF, Collinson PO, Carter GD, Noble MI. Significance of an index of insulin resistance on admission in non-diabetic patients with acute coronary syndromes. Heart 1999, 82:443-447. 1760262, 10490558.
2. Stubbs PJ, Laycock J, Alaghband-Zadeh J, Carter G, Noble MI. Circulating stress hormone and insulin concentrations in acute coronary syndromes: identification of insulin resistance on admission. Clin Sci (Lond) 1999, 96:589-595.
3. Serne EH, Stehouwer CD, ter Maaten JC, ter Wee PM, Rauwerda JA, Donker AJ, et al. Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. Circulation 1999, 99:896-902. 10.1161/01.CIR.99.7.896, 10027812.
4. Kraemer-Aguiar LG, Maranhao PA, Sicuro FL, Bouskela E. Microvascular dysfunction: a direct link among BMI, waist circumference and glucose homeostasis in young overweight/obese normoglycemic women. Int J Obes (Lond) 2010, 34:111-117.
5. de Jongh RT, Serne EH, Ijzerman RG, Stehouwer CD, De VG. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes 2004, 53:2873-2882. 10.2337/diabetes.53.11.2873, 15504968.
6. Kraemer-Aguiar LG, Laflor CM, Bouskela E. Skin microcirculatory dysfunction is already present in normoglycemic subjects with metabolic syndrome. Metabolism 2008, 57:1740-1746. 10.1016/j.metabol.2008.07.034, 19013299.
7. Kraemer-Aguiar LG, Maranhao PA, Cyrino FZ, Bouskela E. Waist circumference leads to prolonged microvascular reactive hyperemia response in young overweight/obese women. Microvasc Res 2010, 80:427-432. 10.1016/j.mvr.2010.08.004, 20833187.
8. Barrett EJ, Eggleston EM, Inyard AC, Wang H, Li G, Chai W, et al. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia 2009, 52:752-764. 10.1007/s00125-009-1313-z, 2704146, 19283361.
9. Rubio-Gayosso I, Platts SH, Duling BR. Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2006, 290:H2247-H2256. 10.1152/ajpheart.00796.2005, 16399871.
10. Nieuwdorp M, Meuwese MC, Vink H, Hoekstra JB, Kastelein JJ, Stroes ES. The endothelial glycocalyx: a potential barrier between health and vascular disease. Curr Opin Lipidol 2005, 16:507-511. 10.1097/01.mol.0000181325.08926.9c, 16148534.
11. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003, 23:168-175. 10.1161/01.ATV.0000051384.43104.FC, 12588755.
12. Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible?. J Am Coll Cardiol 1997, 30:325-333. 10.1016/S0735-1097(97)00189-7, 9247501.
13. Fichtlscherer S, Breuer S, Zeiher AM. Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes: further evidence for the existence of the "vulnerable" patient. Circulation 2004, 110:1926-1932. 10.1161/01.CIR.0000143378.58099.8C, 15451794.
14. Sax FL, Cannon RO, Hanson C, Epstein SE. Impaired forearm vasodilator reserve in patients with microvascular angina. Evidence of a generalized disorder of vascular function. N Engl J Med 1987, 317:1366-1370. 10.1056/NEJM198711263172202, 3683470.
15. de Aguiar LG K, Laflor CM, Bahia L, Villela NR, Wiernsperger N, Bottino DA, et al. Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome. Diabet Med 2007, 24:272-279.
16. de Aguiar LG, Bahia LR, Villela N, Laflor C, Sicuro F, Wiernsperger N, et al. Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance. Diabetes Care 2006, 29:1083-1089. 10.2337/dc05-2146, 16644641.
17. Tanner JM. Growth at adolescence 1962, Oxford: Blackwell.
18. World Health Organization Physical Status: The Use And Interpretation of Anthropometry - Report of a WHO Expert Committee 1995, Geneva: WHO Technical Report Series 854, World Health Organization.
19. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000, 320:1240-1243. 10.1136/bmj.320.7244.1240, 27365, 10797032.
20. Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, et al. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes 2007, 8:299-306. 10.1111/j.1399-5448.2007.00271.x, 17850473.
21. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645. 10.1161/CIRCULATIONAHA.109.192644, 19805654.
22. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003, 289:2560-2572. 10.1001/jama.289.19.2560, 12748199.
23. Clapauch R, Mecenas AS, Maranhao PA, Bouskela E. Early postmenopausal women with cardiovascular risk factors improve microvascular dysfunction after acute estradiol administration. Menopause 2012, 19:672-679. 10.1097/gme.0b013e31823a8f43, 22314638.
24. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):S5-S10. American Diabetes Association.
25. Maranhão PA, Kraemer-Aguiar LG, de Oliveira CL, Kuschnir MC, Vieira YR, Souza MG, et al. Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolecents: a randomized controlled trial. Nutr Metab (Lond) 2011, 8:32-39.
26. Clifton VL, Crompton R, Read MA, Gibson PG, Smith R, Wright IM. Microvascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycle. J Endocrinol 2005, 186:69-76. 10.1677/joe.1.06030, 16002537.
27. Ketel IJ, Stehouwer CD, Serne EH, Poel DM, Groot L, Kager C, et al. Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women. Microcirculation 2009, 16:714-724. 10.3109/10739680903199186, 19905970.
28. Klyscz T, Junger M, Jung F, Zeintl H. Cap image--a new kind of computer-assisted video image analysis system for dynamic capillary microscopy. Biomed Tech (Berl) 1997, 42:168-175.
29. Pearson K. On lines and planes of closest Fit to systems of points in space. Philos Mag 1901, 2:559-572.
30. Manly BFJ. Multivariate statistical methods: a primer 1994, London: Chapman & Hall, 2.
31. Jackson DA. Stopping rules in principal components analysis: a comparison of heuristical and statistical approaches. Ecology 1993, 74:2204-2214.
32. Hammer O, Harper DAT. Paleontological data analysis 2006, Oxford: Blackwell Pub.
33. Hsu FC, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, et al. Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci 2009, 64:581-589. 2800809, 19228783.
34. Wiernsperger N, Nivoit P, De Aguiar LG, Bouskela E. Microcirculation and the metabolic syndrome. Microcirculation 2007, 14:403-438. 10.1080/10739680701285617, 17613811.
35. Taddei S, Virdis A, Ghiadoni L, Sudano I, Salvetti A. Effects of antihypertensive drugs on endothelial dysfunction: clinical implications. Drugs 2002, 62:265-284. 10.2165/00003495-200262020-00003, 11817973.
36. Vogel RA. Cholesterol lowering and endothelial function. Am J Med 1999, 107:479-487. 10.1016/S0002-9343(99)00261-2, 10569303.
37. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998, 97:1695-1701. 10.1161/01.CIR.97.17.1695, 9591763.
38. Voidonikola PT, Stamatelopoulos KS, Alevizaki M, Kollias GE, Zakopoulos NA, Lekakis JP, et al. The association between glycemia and endothelial function in nondiabetic individuals: the importance of body weight. Obesity (Silver Spring) 2008, 16:2658-2662.
39. Han KA, Patel Y, Lteif AA, Chisholm R, Mather KJ. Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans. Diabetes Metab Res Rev 2011, 27:354-361. 10.1002/dmrr.1183, 3090665, 21309061.