The association between glycemia and endothelial function in nondiabetic individuals: The importance of body weight

Obesity

Volumn 16, Issue 12, 2008, Pages 2658-2662

  Voidonikola, Paraskevi T ^a   Stamatelopoulos, Kimon S ^a   Alevizaki, Maria ^a   Kollias, George E ^a   Zakopoulos, Nikolaos A ^a   Lekakis, John P ^a   Anastasiou, Eleni ^a   Theodorakis, Michael J ^a   Pittas, Anastassios G ^b   Papamichael, Christos M ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD; BODY MASS; BRACHIAL ARTERY; ENDOTHELIUM; FEMALE; HUMAN; HYPERGLYCEMIA; MALE; METABOLISM; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; RISK FACTOR; STATISTICAL MODEL; VASODILATATION;

ADULT; ATHEROSCLEROSIS; BODY MASS INDEX; BRACHIAL ARTERY; ENDOTHELIUM; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; LINEAR MODELS; MALE; MIDDLE AGED; OVERWEIGHT; RISK FACTORS; VASODILATION;

EID: 58149311224     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.431     Document Type: Article

References (35)

1. Meigs JB, Nathan DM, D'Agostino RB Sr, Wilson PW. Framingham Offspring Study. Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care 2002;25:1845-1850.
2. Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:434-444.
3. Khaw KT, Wareham N, Bingham S et al. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med 2004;141:413-420.
4. Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 indivinduals followed for 12.4 years. Diabetes Care 1999;22:233-240.
5. de Vegt F, Dekker JM, Ruhé HG et al. Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 1999;42:926-931.
6. Balkau B, Shipley M, Jarrett RJ et al. High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Diabetes Care 1998;21:360-367.
7. Rodriguez CJ, Miyake Y, Grahame-Clarke C et al. Relation of plasma glucose and endothelial function in a population-based multiethnic sample of subjects without diabetes mellitus. Am J Cardiol 2005;96:1273-1277.
8. Thomas GN, Chook P, Qiao M et al. Deleterious impact of "high normal" glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study. Arterioscler Thromb Vasc Biol 2004;24:739-743.
9. Sander D, Schulze-Horn C, Bickel H et al. Combined effects of hemoglobin A1c and C-reactive protein on the progression of subclinical carotid atherosclerosis: the INVADE study. Stroke 2006;37:351-357.
10. Gerstein HC, Anand S, Yi QL et al. The relationship between dysglycemia and atherosclerosis in South cAsian, Chinese, and European individuals in Canada: a randomly sampled cross-sectional study. Diabetes Care 2003;26:144-149.
11. Temelkova-Kurktschiev TS, Koehler C, Henkel E et al. Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care 2000;23:1830-1834.
12. Vitelli LL, Shahar E, Heiss G et al. Glycosylated hemoglobin level and carotid intimal-medial thickening in nondiabetic individuals. The Atherosclerosis Risk in Communities Study. Diabetes Care 1997;20:1454-1458.
13. Ohnishi H, Saitoh S, Takagi S et al. Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose: the Tanno and Sobetsu study. Diabetes Care 2003;26:437-440.
14. Schram MT, Henry RM, van Dijk RA et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension 2004;43:176-181.
15. Henry RM, Ferreira I, Kostense PJ et al. Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study. Atherosclerosis 2004;174: 49-56.
16. Bonora E, Kiechl S, Willeit J et al. Plasma glucose within the normal range is not associated with carotid atherosclerosis: prospective results in subjects with normal glucose tolerance from the Bruneck Study. Diabetes Care 1999;22:1339-1346.
17. Arcaro G, Zamboni M, Rossi L et al. Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord 1999;23:936-942.
18. Balletshofer BM, Rittig K, Enderle MD et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation 2000;101: 1780-1784.
19. Steinberg H, Chaker H, Leaming R et al. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996;97:2601-2610.
20. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983;67:968-977.
21. Abbasi F, Brown BW Jr, Lamendola C, McLaughlin T, Reaven GM. Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol 2002;40:937-943.
22. Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay. N Engl J Med 1984;310: 341-346.
23. Ravikumar R, Deepa R, Shanthirani C, Mohan V. Comparison of Carotid intima-media thickness, arterial stiffness, and brachial artery flow mediated dilatation in diabetic and non-diabetic subjects (The Chennai Urban Population Study [CUPS-9]). Am J Cardiol 2002;90:702-707.
24. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
25. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
26. Celermajer DS, Sorensen KE, Gooch VM et al. Non invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115.
27. Agewall S, Hulthe J, Fagerberg B, Gottfridsson B, Wikstrand J. Post-occlusion brachial artery vasodilatation after ischaemic handgrip exercise is nitric oxide mediated. Clin Physiol Funct Imaging 2002;22:18-23.
28. Aiken LS, West SG. Interactions between categorical and continuous variables. In: Multiple Regression: Testing and Interpreting Interactions. Sage publications, The International Professional Publishers: Newsbury Park, London, 1991.
29. Anastasiou E, Lekakis JP, Alevizaki M et al. Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes. Diabetes Care 1998;21:2111-2115.
30. Schachinger V, Zeiher AM. Prognostic implications of endothelial dysfunction: does it mean anything? Coron Artery Dis 2001;12:435-443.
31. Suwaidi JA, Hamasaki S, Higano ST et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000;101:948-954.
32. Williams IL, Chowienczyk PJ, Wheatcroft SB et al. Endothelial function and weight loss in obese humans. Obes Surg 2005;15:1055-1060.
33. Oflaz H, Ozbey N, Mantar F et al. Determination of endothelial function and early atherosclerotic changes in healthy obese women. Diabetes Nutr Metab 2003;16:176-181.
34. Angulo J, Sanchez-Ferrer C, Peiro C, Marin J, Rodriguez-Manas L. Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human haemoglobin. Hypertension 1996;28:583-592.
35. Williams SB, Goldfine AB, Timini FK et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998;97:1695-1701.