Ingenol mebutate-induced cell death patterns in normal and cancer epithelial cells

Journal of Drugs in Dermatology

Volumn 11, Issue 10, 2012, Pages 1181-1192

  Stahlhut, Martin ^a   Bertelsen, Malene ^a   HØyer Hansen, Maria ^a   Svendsen, Nannette ^a   Eriksson, Andre H ^a   Lord, Janet M ^b   Scheel Toellner, Dagmar ^b   Young, Stephen P ^b   Zibert, John R ^a  

^a LEO PHARMA A S   (Denmark)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INGENOL MEBUTATE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL MEMBRANE; CELL ORGANELLE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; EPITHELIUM CELL; FEMALE; HELA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; KERATINOCYTE; MITOCHONDRION; SKINFOLD THICKNESS; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALCIUM; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL MEMBRANE; CELL SURVIVAL; DETERGENTS; DITERPENES; HELA CELLS; HUMANS; KERATINOCYTES; L-LACTATE DEHYDROGENASE; MITOCHONDRIA; NECROSIS; OCTOXYNOL; SKIN;

EID: 84868623301     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gillespie SK, Zhang XD, Hersey P. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis- inducing ligand-induced apoptosis in melanoma cells. Mol Cancer Ther. 2004;3(12):1651-1658. (Pubitemid 40136721)
2. Ogbourne SM, Suhrbier A, Jones B, Cozzi SJ, Boyle GM, Morris M, et al. Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death. Cancer Res. 2004;6(48):2833-2839. (Pubitemid 38500622)
3. Challacombe JM, Suhrbier A, Parsons PG, et al. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. J Immunol. 2006;177(11):8123-8132. (Pubitemid 44846331)
4. Ersvaer E, Kittang AO, Hampson P, et al. The Protein Kinase C Agonist PEP005 Ingenol 3-Angelate in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity. Toxins. 2010;2(1):174-194.
5. Lebwohl M. Actinic keratosis: epidemiology and progression to squamous cell carcinoma. Br J Dermatol. 2003;149(Suppl 66):31-33. (Pubitemid 38064513)
6. Cockerell CJ. Pathology and pathobiology of the actinic solar.keratosis. Br J Dermatol. 2003;149 (Suppl 66):34-36.
7. Cohen JL. Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. J Clin Aesthet Dermatol. 2010;3(6):39-44.
8. Hampson P, Chahal H, Khanim F, et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood. 2005;106(4):1362-1368. (Pubitemid 41129602)
9. Cozzi SJ, Parsons PG, Ogbourne SM, Pedley J, Boyle GM. Induction of senescence in diterpene ester-treated melanoma cells via protein kinase Cdependent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res. 2006;66(20):10083-10091. (Pubitemid 44672062)
10. Rosen RH, Gupta AK, Tyring SK. Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: Rapid lesion necrosis followed by lesion-specific immune response. J Am Acad Dermatol. 2012;66(3):486-493. Epub 2011 Nov 4.
11. Foghsgaard L, Wissing D, Mauch D, et al. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol. 2001;153(5):999-1010.
12. Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R. The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J. 2001;20(11):2690-2701. (Pubitemid 32938554)
13. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 2000;1(1):11-21.
14. Celsi F, Pizzo P, Brini M, et al. Mitochondria, calcium and cell death: a deadly triad in neurodegeneration. Biochim Biophys Acta. 2009;1787(5):335-344.
15. Le TT, Gardner J, Hoang-Le D, et al. Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies. Vaccine. 2009;27(23):3053-3062.
16. Duchen MR. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol. 1999;516 (Pt 1):1-17. (Pubitemid 29163987)
17. Sparagna GC, Gunter KK, Sheu SS, Gunter TE. Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J Biol Chem. 1995;270(46):27510-27515.
18. Crompton M, Ellinger H, Costi A. Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J. 1988;255(1):357-360.
19. Boissy RE. Melanosome transfer to and translocation in the keratinocyte. Exp Dermatol. 2003;12 (Suppl 2):5-12. (Pubitemid 37526842)
20. Ando H, Niki Y, Ito M, et al. Melanosomes are Transferred from Melanocytes to Keratinocytes through the Processes of Packaging, Release, Uptake, and Dispersion. J Invest Dermatol. 2012;132(4):1222-1229. doi: 10.1038/ jid.2011.413. Epub 2011 Dec 22.