Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 11, 2008, Pages 2553-2559

  Schmuck, Erica ^a   Cappello, Jean ^a   Coggan, Marjorie ^a   Brew, Jenny ^b   Cavanaugh, Juleen A ^b   Blackburn, Anneke C ^a   Baker, Rohan T ^a   Eyre, Helen J ^c   Sutherland, Grant R ^c   Board, Philip G ^a  

^a Australian National University   (Australia)

^b Canberra Hospital   (Australia)

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Arsenic biotransformation; Drug resistance; Glutathione transferase Omega; Glutatione transferase deficiency; GSTO1 1

Indexed keywords

4 NITROPHENACYLGLUTATHIONE; ARSENIC TRIOXIDE; CISPLATIN; CYTOTOXIC AGENT; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE OMEGA 1 1; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME METABOLISM; ENZYME SUBSTRATE; GENE DELETION; GENETIC POLYMORPHISM; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOBLASTOID CELL; MULTIDRUG RESISTANCE; NORTHERN BLOTTING; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ARSENICALS; CELL LINE, TUMOR; CYTOTOXINS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENOTYPE; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; HUMANS; OXIDES; POLYMORPHISM, GENETIC;

EID: 48349093748     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.04.017     Document Type: Article

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