Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages 4071-4079

  González, Frank ^a   Sia, Chang Ling ^a   Shepard, Marguerite K ^a   Rote, Neal S ^b   Minium, Judi ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL FAT; ABDOMINAL OBESITY; ADULT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INFLAMMATION; INSULIN SENSITIVITY; MONONUCLEAR CELL; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL;

ABDOMINAL FAT; ADIPOSITY; ADULT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERGLYCEMIA; INFLAMMATION; INSULIN RESISTANCE; LEUKOCYTES, MONONUCLEAR; NF-KAPPA B; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84868609688     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2131     Document Type: Article

References (40)

1. González F, Rote NS, Minium J, Kirwan JP 2006 Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab 91:336-340 (Pubitemid 43069159)
2. Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N 2001 Low grade chronic inflammation in women in women with polycystic ovary syndrome. J Clin Endocrinol Metab 86:2453-2455 (Pubitemid 32545690)
3. Fenkci V, Fenkci S, Yilmazer M, Serteser M 2003 Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease. Fertil Steril 80:123-127
4. Gonzalez F, Thusu K, Abdel-Rahman E, Prabhala A, Tomani M, Dandona P 1999 Elevated serum levels of tumor necrosis factor α in normal-weight women with polycystic ovary syndrome. Metabolism 48:437-441 (Pubitemid 29174220)
5. Dunaif A, Segal KR, Futterweit W, Dobrjansky A 1989 Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:1165-1174 (Pubitemid 19250404)
6. Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A 2005 Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab 288:E1047-E1054 (Pubitemid 40547900)
7. Yin J, Gao Z, He Q, Zhou D, Guo Z, Ye J 2009 Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 296:E333-E342
8. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW 2003 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808 (Pubitemid 38063703)
9. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS 2005 Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347-2355 (Pubitemid 41532523)
10. Groemping Y, Rittinger K 2005 Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J 386:401-416 (Pubitemid 40445864)
11. Chanock SJ, el Benna J, Smith RM, Babior BM 1994 The respiratory burst oxidase. J Biol Chem 269:24519-24522 (Pubitemid 24311695)
12. Baldwin Jr AS 2001 The transcription factor NFκB and human disease. J Clin Invest 107:3-6
13. Barnes PJ, Karin M 1997 Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071 (Pubitemid 27163860)
14. Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF 2001 Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest 107:181-189 (Pubitemid 32096834)
15. González F, Rote NS, Minium J, Kirwan JP 2007 Insulin sensitivity and hyperandrogenism in polycystic ovary syndrome are related to activated nuclear factor κB from mononuclear cells in the fasting state. Program of the 89th Annual Meeting of The Endocrine Society, Toronto, Ontario, Canada, p 142 (Abstract OR50-3)
16. González F, Rote NS, Minium J, Kirwan JP 2006 Increased activation of nuclear factor κB triggers inflammation and insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab 91:1508-1512
17. González F, Minium J, Rote NS, Kirwan JP 2005 Hyperglycemia alters tumor necrosis factor-α release from mononuclear cells in women with polycystic ovary syndrome. J Clin Endocrinol Metab 90:5336-5342 (Pubitemid 41262298)
18. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G 2007 Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. J Clin Endocrinol Metab 92:2500-2505 (Pubitemid 47037349)
19. Modan M, Harris MI, Halkin H 1989 Evaluation of WHO and NDDG criteria for impaired glucose tolerance. Results from two national samples. Diabetes 38:1630-1635 (Pubitemid 20007890)
20. Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care 22:1462-1470
21. Kohrt WM, Kirwan JP, Staten MA, Bourey FE, King DS, Holloszy JO 1993 Insulin resistance of aging is related to abdominal obesity. Diabetes 42:273-281 (Pubitemid 23045031)
22. González F, Rote NS, Minium J, O'Leary VB, Kirwan JP 2007 Obese reproductive age women exhibit a proatherogenic inflammatory response during hyperglycemia. Obesity 15:2436-2444 (Pubitemid 350034037)
23. Aljada A, Ghanim H, Dandona P 2002 Translocation of p47phox and activation of NADPH oxidase in mononuclear cells. Methods Mol Biol 196:99-103
24. González F, Rote NS, Minium J, Kirwan JP 2006 In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome. J Endocrinol 188:521-529
25. Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, Gurley C, Simpson P, McGehee Jr RE, Kern PA, Peterson CA 2009 Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab 296:E1300-E1310
26. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM 1994 Tumor necrosis factor α inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA 91:4854-4858 (Pubitemid 24177748)
27. Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG 2008 Ablation of CD11c-positive cells normalize insulin sensitivity in obese insulin resistant animals. Cell Metab 8:301-309
28. Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P 2002 Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am J Clin Nutr 75:767-772 (Pubitemid 34250692)
29. Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V 2001 Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma orthotyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab 862:899-2902
30. Best CL, Pudney J, Welch WR, Burger N, Hill JA 1996 Localization and characterization of white blood cell populations within the human ovary throughout the menstrual cycle and menopause. Hum Reprod 11:790-797 (Pubitemid 26142179)
31. Piotrowski PC, Rzepczynska IJ, Kwintkiewicz J, Duleba AJ 2005 Oxidative stress induces expression of CYP11A, CYP17, STAR and 3βHSD in rat theca-interstitial cells. J Soc Gynecol Invest 12 (Suppl 2):319A (Abstract)
32. Wong DH, Villanueva JA, Cress AB, Sokalska A, Ortega I, Duleba AJ 2011 Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Fertil Steril 96:1252-1258
33. Spaczynski RZ, Arici A, Duleba AJ 1999 Tumor necrosis factor α stimulates proliferation of rat ovarian theca-interstitial cells. Biol Reprod 61:993-998 (Pubitemid 29455636)
34. Sokalska A, Piotrowski PC, Rzepczynska IJ, Cress A, Duleba AJ 2010 Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. J Clin Endocrinol Metab 95:5390-5394
35. González F, Sia CL, Stanczyk FZ, Blair HE, Krupa ME 1 July 2012 Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome. Endocrine 10.1007/s12020-012-9728-6
36. Fain JN, Bahouth SW, Madan AK 2004 TNFα release by nonfat cells of adipose tissue. Int J Obes 28:616-622 (Pubitemid 38491155)
37. Lindholm A, Blomquist C, Bixo M, Dahlbom I, Hansson T, Sundström Poromaa I, Burén J 2011 No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls. Hum Reprod 26:1478-1485
38. Tosi F, Negri C, Perrone F, Dorizzi R, Castello R, Bonora E, Moghetti P 2012 Hyperinsulinemia amplifies GnRH agonist stimulated ovarian steroid secretion in women with polycystic ovary syndrome. J Clin Endocrinol Metab 97:1712-1719
39. Holte J, Bergh T, Gennarelli G, Wide L 1994 The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol 41:473-481 (Pubitemid 24301280)
40. Xu X, De Pergola G, Björntorp P 1990 The effects of androgens on the regulation of lipolysis in adipose precursor cells. Endocrinology 126:1229-1234 (Pubitemid 20079545)