Interactions outside the boundaries of the canonical binding groove of a pdz domain influence ligand binding

Biochemistry

Volumn 51, Issue 44, 2012, Pages 8971-8979

  Chi, Celestine N ^a   Haq, S Raza ^a   Rinaldo, Serena ^b   Dogan, Jakob ^a   Cutruzzolà, Francesca ^b   Engström, Åke ^a   Gianni, Stefano ^b   Lundström, Patrik ^c   Jemth, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; BINDING SURFACE; C-TERMINUS; FLUORESCENCE INTENSITIES; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; N-TERMINALS; NATURAL LIGANDS; NUCLEAR OVERHAUSER ENHANCEMENT; PDZ DOMAINS; PEPTIDE BINDING; PEPTIDE LIGAND; POSTSYNAPTIC DENSITIES; PROTEIN LIGANDS; PROTEIN-PROTEIN INTERACTIONS; SITE DIRECTED MUTAGENESIS; SPECIFIC INTERACTION; STRUCTURAL ELEMENTS; WILD TYPES;

EXPERIMENTS; LIGANDS; PEPTIDES;

BINDING SITES;

CRIPT PEPTIDE; MUTANT PROTEIN; PDZ PROTEIN; PDZ3 PROTEIN; PEPTIDE; POSTSYNAPTIC DENSITY PROTEIN 95; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTROPY; FLUORESCENCE ANALYSIS; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CALORIMETRY; ENTROPY; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PDZ DOMAINS; PROTEIN BINDING;

EID: 84868600086     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300792h     Document Type: Article

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