-
1
-
-
33646259689
-
Anticipating clinical resistance to target-directed agents: The BCR-ABL paradigm
-
Azam M, Daley GQ (2006) Anticipating clinical resistance to target-directed agents: the BCR-ABL paradigm. Mol Diagn Ther 10: 67-76
-
(2006)
Mol Diagn Ther
, vol.10
, pp. 67-76
-
-
Azam, M.1
Daley, G.Q.2
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70 (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
0035902180
-
Oncogenic kinase signalling
-
DOI 10.1038/35077225
-
Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Nature 411: 355-65 (Pubitemid 32467045)
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
4
-
-
0037013143
-
The conformational plasticity of protein kinases
-
DOI 10.1016/S0092-8674(02)00741-9
-
Huse M, Kuriyan J (2002) The conformational plasticity of protein kinases. Cell 109: 275-82 (Pubitemid 34606870)
-
(2002)
Cell
, vol.109
, Issue.3
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
6
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
Cohen P (2002) Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1: 309-15 (Pubitemid 37361447)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.4
, pp. 309-315
-
-
Cohen, P.1
-
7
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey J, Sausville EA (2003) Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov 2: 296-313 (Pubitemid 37361688)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.4
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
8
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
DOI 10.1126/science.1095920
-
Noble ME, Endicott JA, Johnson LN (2004) Protein kinase inhibitors: insights into drug design from structure. Science 303: 1800-5 (Pubitemid 38374863)
-
(2004)
Science
, vol.303
, Issue.5665
, pp. 1800-1805
-
-
Noble, M.E.M.1
Endicott, J.A.2
Johnson, L.N.3
-
9
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
DOI 10.1056/NEJM200104053441402
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M (2001) Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lympho-blastic leukemia with the Philadelphia chromosome. N Engl J Med 344: 1038-42 (Pubitemid 32267973)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
10
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2: 561-6
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
11
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
DOI 10.1126/science.1062538
-
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293: 876-80 (Pubitemid 32743979)
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Nagesh Rao, P.6
Sawyers, C.L.7
-
12
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
DOI 10.1016/S1535-6108(02)00096-X
-
Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, Sawyers CL (2002) Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2: 117-25 (Pubitemid 41039112)
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Sawyers, C.L.7
-
13
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
DOI 10.1182/blood.V99.9.3472
-
Branford S, Rudzki Z, Walsh S, Grigg A, Arthur C, Taylor K, Herrmann R, Lynch KP, Hughes TP (2002) High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99: 3472-5 (Pubitemid 34525335)
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
Grigg, A.4
Arthur, C.5
Taylor, K.6
Herrmann, R.7
Lynch, K.P.8
Hughes, T.P.9
-
14
-
-
0037459344
-
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
-
DOI 10.1016/S0092-8674(03)00190-9
-
Azam M, Latek RR, Daley GQ (2003) Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112: 831-43 (Pubitemid 36378885)
-
(2003)
Cell
, vol.112
, Issue.6
, pp. 831-843
-
-
Azam, M.1
Latek, R.R.2
Daley, G.Q.3
-
15
-
-
33745164854
-
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance
-
DOI 10.1073/pnas.0600001103
-
Azam M, Nardi V, Shakespeare WC, Metcalf CA 3rd, Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ (2006) Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci USA 103: 9244-9 (Pubitemid 43902563)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.24
, pp. 9244-9249
-
-
Azam, M.1
Nardi, V.2
Shakespeare, W.C.3
Metcalf III, C.A.4
Bohacek, R.S.5
Wang, Y.6
Sundaramoorthi, R.7
Sliz, P.8
Veach, D.R.9
Bornmann, W.G.10
Clarkson, B.11
Dalgarno, D.C.12
Sawyer, T.K.13
Daley, G.Q.14
-
16
-
-
74549122017
-
AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance
-
Azam M, Powers JT, Einhorn W, Huang WS, Shakespeare WC, Zhu X, Dalgarno D, Clackson T, Sawyer TK, Daley GQ (2010) AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance. Chem Biol Drug Des 75: 223-7
-
(2010)
Chem Biol Drug des
, vol.75
, pp. 223-227
-
-
Azam, M.1
Powers, J.T.2
Einhorn, W.3
Huang, W.S.4
Shakespeare, W.C.5
Zhu, X.6
Dalgarno, D.7
Clackson, T.8
Sawyer, T.K.9
Daley, G.Q.10
-
17
-
-
53549104402
-
Activation of tyrosine kinases by mutation of the gatekeeper threonine
-
Azam M, Seeliger MA, Gray NS, Kuriyan J, Daley GQ (2008) Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol 15: 1109-18
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 1109-1118
-
-
Azam, M.1
Seeliger, M.A.2
Gray, N.S.3
Kuriyan, J.4
Daley, G.Q.5
-
18
-
-
0346670259
-
A screen to identify drug resistant variants to target-directed anti-cancer agents
-
DOI 10.1251/bpo63
-
Azam M, Raz T, Nardi V, Opitz SL, Daley GQ (2003) A screen to identify drug resistant variants to target-directed anti-cancer agents. Biol Proced Online 5: 204-10 (Pubitemid 38097516)
-
(2003)
Biological Procedures Online
, vol.5
, Issue.1
, pp. 204-210
-
-
Azam, M.1
Raz, T.2
Nardi, V.3
Opitz, S.L.4
Daley, G.Q.5
-
19
-
-
0037114239
-
Novel ret-roviral vectors to facilitate expression screens in mammalian cells
-
Koh EY, Chen T, Daley GQ (2002) Novel ret-roviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res 30: e142
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Koh, E.Y.1
Chen, T.2
Daley, G.Q.3
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