Carbodiimides in the synthesis of enamino- and α-aminophosphonates as peptidomimetics of analgesic/antiinflammatory and anticancer agents

Archiv der Pharmazie

Volumn 345, Issue 11, 2012, Pages 884-895

  Abdou, Wafaa M ^a   Barghash, Reham F ^a   Bekheit, Mohamed S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Aminophosphonates; Analgesic antiinflammatory agents; Antitumor bioassay; Enaminophosphonates; Horner Emmons reagents; Pyrazoles

Indexed keywords

3 ETHYL 6 METHYL 7 AMINO 6 (DIETHOXYPHOSPHORYL) 1 PHENYL 5 (PHENYLIMINO) 5,6 DIHYDRO 1H PYRAZOLO[4,3 B]PYRIDINE 3,6 DICARBOXYLATE; [3 CYANO 7 OXO 2,6 DIPHENYL 6,7 DIHYDRO 2H PYRAZOLO[4,3 D]PYRIMIDIN 5 YL] N,N,N,N TETRAETHYLPHOSPHONIC DIAMIDE; [3 CYANO 7 OXO 2,6 DIPHENYL 6,7 DIHYDRO 2H PYRAZOLO[4,3 D]PYRIMIDIN 5 YL] N,N,N,N TETRAMETHYLPHOSPHONIC DIAMIDE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; CYANAMIDE; DIETHYL 3 CYANO 7 OXO 2,6 DIPHENYL 6,7 DIHYDRO 2H PYRAZOLO[4,3 D]PYRIMIDIN 5 YLPHOSPHONATE; DIETHYL 7 AMINO 6 (DIETHOXYPHOSPHORYL) 1 PHENYL 5 (PHENYLIMINO) 5,6 DIHYDRO 1H PYRAZOLO[4,3 B]PYRIDINE 3,6 DICARBOXYLATE; DIMETHYL 3 CYANO 7 OXO 2,6 DIPHENYL 6,7 DIHYDRO 2H PYRAZOLO[4,3 D]PYRIMIDIN 5 YLPHOSPHONATE; DOXORUBICIN; ETHYL 4 AMINO 5 CYANO 1 PHENYL 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 5 CYANO 4 [2 ETHOXY 5 (PHENYLIMINO) 2,5 DIHYDRO 1H 1,2 AZAPHOSPHOLYL 2 OXIDE] 1 PHENYL 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 5 CYANO 4 [3 (DIETHOXYPHOSPHORYL) 4 METHYL 2 (PHENYLAMINO) 1H PYRROL 1 YL] 1 PHENYL 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 7 AMINO 6 (DIETHOXYPHOSPHORYL) 6 (METHYLTHIO) 1 PHENYL 5 (PHENYLIMINO) 5,6 DIHYDRO 1H PYRAZOLO[4,3 B]PYRIDINE 3 CARBOXYLATE; ETHYL 7 AMINO 6 CARBAMOTHIOYL 6 (DIETHOXYPHOSPHORYL) 1 PHENYL 5 (PHENYLIMINO) 5,6 DIHYDRO 1H PYRAZOLO[4,3 B]PYRIDINE 3 CARBOXYLATE; INDOMETACIN; PEPTIDOMIMETIC AGENT; PHOSPHINIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; INFLAMMATION; LIVER CANCER; MOUSE; NONHUMAN; PAW EDEMA; POLYMERIZATION; PRIORITY JOURNAL; PROTON TRANSPORT; REACTION ANALYSIS; UTERINE CERVIX CANCER;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CARBODIIMIDES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG STABILITY; HUMANS; INFLAMMATION; MALE; MICE; NEOPLASMS; ORGANOPHOSPHONATES; PAIN; PEPTIDOMIMETICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868597341     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201200142     Document Type: Article

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