Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch

Europace

Volumn 14, Issue SUPPL. 5, 2012, Pages

  Hubbard, Marjorie Letitia ^a   Henriquez, Craig S ^a  

^a Duke University   (United States)

Author keywords

Cardiac microstructure; Gap junction coupling; Interstitial heterogeneity; Sodium current; Source load mismatch; Wavefront curvature

Indexed keywords

ANATOMICAL VARIATION; ARTICLE; CELL HETEROGENEITY; CELL SHAPE; CELL STRUCTURE; COMPUTER MODEL; GAP JUNCTION; HEART; HEART BLOCK; HEART CONDUCTION; HEART MUSCLE CELL; HEART VENTRICLE; INTERSTITIUM; INTRACELLULAR SPACE; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; GUINEA PIGS; HEART CONDUCTION SYSTEM; MEMBRANE POTENTIALS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; NEURAL CONDUCTION;

EID: 84868595272     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eus267     Document Type: Article

References (34)

1. Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest, 1991;87:1594-602.
2. Debakker JMT, Vancapelle FJL, Janse MJ, Tasseron S, Vermeulen JT, Dejonge N et al. Slow conduction in the infarcted human heart - zigzag course of activation. Circulation 1993;88:915-26.
3. Cascio WE, Yang H, Muller-Borer BJ, Johnson TA. Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation. J Electrocardiol 2005;38:55-9.
4. Liu X, Shi HF, Tan HW, Wang XH, Zhou L, Gu JN. Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms. Cardiology 2009;114:22-9.
5. Fleischhauer J, Lehmann L, Kleber AG. Electrical resistances of interstitial and microvascular space as determinants of the extracellular electrical-field and velocity of propagation in ventricular myocardium. Circulation 1995;92:587-94.
6. Frank JS, Langer GA. The myocardial interstitium: its structure and its role in ionic exchange. J Cell Biol 1974;60:586-601.
7. Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovasc Res 2002;54:361-79.
8. Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klovekorn WP et al. Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem 2003;242:135-44.
9. Steinberg BE, Glass L, Shrier A, Bub G. The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue. Philos Trans R Soc A - Math Phys Eng Sci 2006;364:1299-311.
10. Spach MS, Heidlage IF, Barr RC, Dolber PC. Cell size and communication: role in structural and electrical development and remodeling of the heart. Heart Rhythm 2004;1:500-515.
11. Spach MS, Heidlage JF. The stochastic nature of cardiac propagation at a microscopic level - electrical description of myocardial architecture and its application to conduction. Circ Res 1995;76:366-80.
12. Wang Y, Rudy Y. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol 2000;278:H1019-29.
13. Rohr S, Kucera JP, Kleber AG. Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ Res 1998;83:781-94.
14. Bian WN, Tung L. Structure-related initiation of reentry by rapid pacing in monolayers of cardiac cells. Circ Res 2006;98:E29-38.
15. Spach MS, Heidlage JF, Dolber PC, Barr RC. Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Heart Rhythm 2007;4:175-85.
16. Cabo C, Boyden PA. Extracellular space attentuates the effect of gap junctional remodeling on wave propagation: a computational study. 2009;96:3092-101.
17. Hubbard ML, Henriquez CS. Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. Am J Physiol Heart Circ Physiol 2010; 298:H1209-18.
18. Roberts SF, Stinstra JG, Henriquez CS. Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model. Biophys J 2008;95:3724-37.
19. Veeraraghavan R, Salama ME, Poelzing S. Interstitial volume modulates the conduction velocity - gap junction relationship. Am J Physiol Heart Circ Physiol. 2011.
20. Henriquez CS. Simulating the electrical behavior of cardiac tissue using the bidomain model. Crit Rev Biomed Eng 1993;21:1-77.
21. Colli-Franzone P, Pavarino LF, Taccardi B. Simulating patterns of excitation, repolarization and action potential duration with cardiac bidomain and monodomain models. Math Biosci 2005;197:35-66.
22. Hubbard ML, Ying W, Henriquez CS. Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Europace 2007;9:vi20-8.
23. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential. 1. Simulations of ionic currents and concentration changes. Circ Res 1994;74:1071-96.
24. Crank J, Nicolson P. A practical method for numerical evaluation of solutions of partial differential equations of the heat-conduction type. Adv Comput Math 1996; 6:207-26.
25. Pormann J. A modular simulation system for the bidomain equations. Ph.D. Thesis. Duke University Department of Electrical and Computer Engineering. 1999.
26. Cabo C, Pertsov AM, Baxter WT, Davidenko JM, Gray RA, Jalife J. Wave-front curvature as a cause of slow conduction and block in isolated cardiac-muscle. Circ Res 1994;75:1014-28.
27. Fast VG, Kleber AG. Role of wavefront curvature in propagation of cardiac impulse. Cardiovasc Res 1997;33:258-71.
28. Shaw RM, Rudy Y. Ionic mechanisms of propagation in cardiac tissue - roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 1997;81:727-41.
29. Kleber AG, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 2004;84:431-88.
30. Fast VG, Kleber AG. Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc Res 1995;29:697-707.
31. Rohr S, Kucera JP, Fast VG, Kleber AG. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 1997;275:841-4.
32. Kim J, Bursac N, Henriquez C. A computer model of engineering cardiac monolayers. Biophys J 2010;98:1762-71.
33. Fast VG, Kleber AG. Microscopic conduction in cultured strands of neonatal rat-heart cells measured with voltage-sensitive dyes. Circ Res 1993;73:914-25.
34. Badie N, Bursac N. Novel micropatterned cardiac cell cultures with realistic ventricular microstructure. Biophys J 2009;96:3873-85.