Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Biochemistry

Volumn 51, Issue 44, 2012, Pages 8743-8754

  Mbughuni, Michael M ^a   Meier, Katlyn K ^b   Münck, Eckard ^b   Lipscomb, John D ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AROMATIC RINGS; AROMATIC SUBSTRATES; CATALYTIC CYCLES; ELECTRON DELOCALIZATION; ELECTRON TRANSFER; MOSSBAUER; OXYGEN ACTIVATIONS; SEMIQUINONES; STOPPED-FLOW STUDIES; TRANSIENT KINETIC ANALYSIS;

AMINO ACIDS; CHROMOPHORES; ELECTRON AFFINITY; FREE RADICAL REACTIONS; HYDROGEN BONDS; MOLYBDENUM; PHENOLS; REACTION INTERMEDIATES;

SUBSTRATES;

3,4 DIHYDROXYPHENYLACETATE 2,3 DIOXYGENASE; 3,4 DIHYDROXYPHENYLACETIC ACID; DIOXYGENASE; FERROUS ION; OXYGEN; PHENYLALANINE; PROTEIN VARIANT; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHROMATOPHORE; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; FREEZING; HYDROGEN BOND; MOSSBAUER SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

3,4-DIHYDROXYPHENYLACETIC ACID; AMINO ACID SEQUENCE; BREVIBACTERIUM; CATALYTIC DOMAIN; DIOXYGENASES; FERROUS COMPOUNDS; KINETICS; OXYGEN; REACTIVE OXYGEN SPECIES; TYROSINE;

EID: 84868584569     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301114x     Document Type: Article

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