Activated G1s signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice

Blood

Volumn 120, Issue 17, 2012, Pages 3425-3435

  Schepers, Koen ^a   Hsiao, Edward C ^a,b   Garg, Trit ^a   Scott, Mark J ^b   Passegué, Emmanuelle ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 4 RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW APLASIA; CELL COUNT; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ERYTHROCYTE; ERYTHROPOIESIS; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; FIBROUS DYSPLASIA; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; INJURY; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; STEM CELL NICHE; THROMBOCYTE; TRABECULAR BONE; TRANSGENIC MOUSE; ANIMAL; BONE; BONE DENSITY; BONE DEVELOPMENT; BONE MARROW; CELL COMMUNICATION; FLOW CYTOMETRY; GENETICS; METABOLISM; PATHOLOGY; PURE RED CELL ANEMIA;

ANIMALS; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; BONE MARROW; CELL COMMUNICATION; CELL COUNT; ERYTHROPOIESIS; FEMALE; FIBROUS DYSPLASIA OF BONE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; RECEPTORS, SEROTONIN, 5-HT4; RED-CELL APLASIA, PURE; SIGNAL TRANSDUCTION; STEM CELL NICHE;

EID: 84868581981     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-11-395418     Document Type: Article

References (47)

1. Howlader N, Noone A, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2008, National Cancer Institute, Bethesda, MD. http://seer.cancer. gov/csr/1975-2008. Accessed November 16, 2011.
2. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631-644. (Pubitemid 351260057)
3. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006;6(2):93-106. (Pubitemid 43361585)
4. Warr M, Pietras E, Passegué E. Mechanisms controlling HSC functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip Rev Syst Biol Med. 2011;3(6):681-701.
5. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-846. (Pubitemid 37351468)
6. Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 2004;103(9):3258-3264. (Pubitemid 38525648)
7. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836-841. (Pubitemid 37351467)
8. Mendez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010; 466(7308):829-834.
9. Omatsu Y, Sugiyama T, Kohara H, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010;33(3):387-399.
10. Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012; 481(7382):457-462.
11. Butler JM, Nolan DJ, Vertes EL, et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010;6(3):251-264.
12. Chitteti BR, Cheng YH, Streicher DA, et al. Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function. J Cell Biochem. 2010; 111(2):284-294.
13. Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007;129(6):1081-1095. (Pubitemid 46908695)
14. Walkley CR, Olsen GH, Dworkin S, et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007;129(6):1097-1110. (Pubitemid 46908696)
15. Raaijmakers MH, Mukherjee S, Guo S, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010; 464(7290):852-857.
16. Wu JY, Purton LE, Rodda SJ, et al. Osteoblastic regulation of B lymphopoiesis is mediated by Gsα-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008;105(44):16976-16981.
17. Juppner H, Abou-Samra AB, Freeman M, et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 1991;254(5034):1024-1026. (Pubitemid 21917436)
18. Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19): 1434-1441. (Pubitemid 32402100)
19. Brunner S, Zaruba MM, Huber B, et al. Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow. Exp Hematol. 2008;36(9):1157-1166.
20. Adams GB, Martin RP, Alley IR, et al. Therapeutic targeting of a stem cell niche. Nat Biotechnol. 2007;25(2):238-243. (Pubitemid 46227124)
21. Ballen KK, Shpall EJ, Avigan D, et al. Phase I trial of parathyroid hormone to facilitate stem cell mobilization. Biol Blood Marrow Transplant. 2007; 13(7):838-843. (Pubitemid 46902439)
22. Weinstein LS, Liu J, Sakamoto A, Xie T, Chen M. Minireview. GNAS: normal and abnormal functions. Endocrinology. 2004;145(12):5459-5464. (Pubitemid 39564584)
23. Conklin BR, Hsiao EC, Claeysen S, et al. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008;5(8):673-678.
24. Chang WC, Ng JK, Nguyen T, et al. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS One. 2007;2(12): e1317.
25. Hsiao EC, Boudignon BM, Chang WC, et al. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008;105(4):1209-1214. (Pubitemid 351397032)
26. Tumbar T, Guasch G, Greco V, et al. Defining the epithelial stem cell niche in skin. Science. 2004; 303(5656):359-363. (Pubitemid 38095773)
27. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell. 2006;126(2):415-426. (Pubitemid 44092964)
28. Santaguida M, Schepers K, King B, et al. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009;15(4):341-352.
29. Pronk CJ, Rossi DJ, Mansson R, et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2007;1(4):428-442. (Pubitemid 47506534)
30. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001; 98(12):3261-3273.
31. Winkler IG, Sims NA, Pettit AR, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSC. Blood. 2010;116(23):4815-4828.
32. Winkler IG, Barbier V, Wadley R, Zannettino AC, Williams S, Levesque JP. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood. 2010;116(3):375-385.
33. Kazakia GJ, Speer D, Shanbhag S, et al. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011;89(1):10-20.
34. Albright F, Aub JC, Bauer W. Hyperparathyroidism: a common and polymorphic condition as illustrated by seventeen proved cases from one clinic. JAMA. 1934;102(16):1276-1287.
35. Harris WH, Dudley HR Jr, Barry RJ. The natural history of fibrous dysplasia: an orthopaedic, pathological, and roentgenographic study. J Bone Joint Surg Am. 1962;44A:207-233.
36. Calvi LM, Bromberg O, Rhee Y, et al. Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells. Blood. 2012;119(11):2489-2499.
37. Varricchio L, Mancini A, Migliaccio AR. Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis. Expert Rev Hematol. 2009; 2(3):315-334.
38. Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet. 2008;9(2):115-128.
39. Dempster DW, Muller R, Zhou H, et al. Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism. Bone. 2007; 41(1):19-24. (Pubitemid 46891902)
40. Sikole A. Pathogenesis of anaemia in hyperparathyroidism. Med Hypotheses. 2000;54(2):236-238. (Pubitemid 30170968)
41. Bajpai A, Greenway A, Zacharin M. Platelet dysfunction and increased bleeding tendency in McCune-Albright syndrome. J Pediatr. 2008; 153(2):287-289. (Pubitemid 351970568)
42. Li X, Liu H, Qin L, et al. Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem. 2007;282(45):33086-33097. (Pubitemid 350159330)
43. Mendez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature. 2008;452(7186):442-447. (Pubitemid 351450836)
44. Zaccolo M, Cesetti T, Di Benedetto G, et al. Imaging the cAMP-dependent signal transduction pathway. Biochem Soc Trans. 2005;33(6):1323-1326. (Pubitemid 41779678)
45. Park JH, Song HI, Rho JM, et al. Parathyroid hormone (1-34) augments angiopoietin-1 expression in human osteoblast-like cells. Exp Clin Endocrinol Diabetes. 2006;114(8):438-443. (Pubitemid 44620488)
46. Wang BL, Dai CL, Quan JX, et al. Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells. J Endocrinol Invest. 2006;29(2):101-108.
47. Zhang X, Odom DT, Koo SH, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102(12):4459-4464. (Pubitemid 40397134)