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Volumn 27, Issue 12, 2012, Pages 1248-1257

The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease

(15)  Rosenberg, P B a,b   Mielke, M M a,b,c   Han, D a,b   Leoutsakos, J S a,b,d   Lyketsos, C G a,b,d   Rabins, P V a,b   Zandi, P P d   Breitner, J C S e,f   Norton, M C g   Welsh Bohmer, K A h   Zuckerman, I H i   Rattinger, G B i   Green, R C j,k   Corcoran, C g   Tschanz, J T g  


Author keywords

Alzheimer's disease; antidepressants; antipsychotics; cognition; epidemiology; neuropsychiatric symptoms; pharmacoepidemiology; psychosocial function; SSRI

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; CHOLINESTERASE INHIBITOR; MEMANTINE; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR;

EID: 84868581939     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.3769     Document Type: Article
Times cited : (102)

References (39)
  • 1
    • 0033595026 scopus 로고    scopus 로고
    • APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: The Cache County Study
    • Breitner JC, Wyse BW, Anthony JC, et al., 1999. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology 53: 321-331.
    • (1999) Neurology , vol.53 , pp. 321-331
    • Breitner, J.C.1    Wyse, B.W.2    Anthony, J.C.3
  • 2
    • 0027985334 scopus 로고
    • The neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
    • Cummings JL, Mega M, Gray K, et al., 1994. The neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44: 2308-2314.
    • (1994) Neurology , vol.44 , pp. 2308-2314
    • Cummings, J.L.1    Mega, M.2    Gray, K.3
  • 3
    • 79953819258 scopus 로고    scopus 로고
    • Do treatment effects vary among differing baseline depression criteria in depression in Alzheimer's disease study +/- 2 (DIADS-2)?
    • DOI: 10.1002/gps.2565
    • Drye LT, Martin BK, Frangakis CE, et al., 2010. Do treatment effects vary among differing baseline depression criteria in depression in Alzheimer's disease study +/- 2 (DIADS-2)? Int J Geriatr Psychiatry. DOI: 10.1002/gps.2565.
    • (2010) Int J Geriatr Psychiatry
    • Drye, L.T.1    Martin, B.K.2    Frangakis, C.E.3
  • 4
    • 33847701675 scopus 로고    scopus 로고
    • The effects of commonly prescribed drugs in patients with Alzheimer's disease on the rate of deterioration
    • DOI: 10.1136/jnnp.2006.104034; jnnp.2006.104034 [pii]
    • Ellul J, Archer N, Foy CM, et al., 2007. The effects of commonly prescribed drugs in patients with Alzheimer's disease on the rate of deterioration. J Neurol Neurosurg Psychiatry 78: 233-239. DOI: 10.1136/jnnp.2006.104034; jnnp.2006.104034 [pii].
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 233-239
    • Ellul, J.1    Archer, N.2    Foy, C.M.3
  • 5
    • 0037471548 scopus 로고    scopus 로고
    • Central nervous system active medications and risk for fractures in older women
    • DOI: 10.1001/archinte.163.8.949
    • Ensrud KE, Blackwell T, Mangione CM, et al., 2003. Central nervous system active medications and risk for fractures in older women. Arch Intern Med 163: 949-957. DOI: 10.1001/archinte.163.8.949.
    • (2003) Arch Intern Med , vol.163 , pp. 949-957
    • Ensrud, K.E.1    Blackwell, T.2    Mangione, C.M.3
  • 6
    • 0016823810 scopus 로고
    • "mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • 0022-3956(75)90026-6 [pii]
    • Folstein MF, Folstein SE, McHugh PR,. 1975. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198. 0022-3956(75)90026-6 [pii].
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 7
    • 34848814812 scopus 로고    scopus 로고
    • Treatment of dementia in community-dwelling and institutionalized medicare beneficiaries
    • DOI: 10.1111/j.1532-5415.2007.01387.x
    • Gruber-Baldini AL, Stuart B, Zuckerman IH, Simoni-Wastila L, Miller R,. 2007. Treatment of dementia in community-dwelling and institutionalized medicare beneficiaries. J Am Geriatr Soc 55: 1508-1516. DOI: 10.1111/j.1532-5415.2007. 01387.x.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 1508-1516
    • Gruber-Baldini, A.L.1    Stuart, B.2    Zuckerman, I.H.3    Simoni-Wastila, L.4    Miller, R.5
  • 8
    • 67749144236 scopus 로고    scopus 로고
    • Use of antipsychotics among elderly nursing home residents with dementia in the US: An analysis of National Survey Data
    • DOI: 10.2165/00002512-200926060-00005
    • Kamble P, Chen H, Sherer JT, Aparasu RR,. 2009. Use of antipsychotics among elderly nursing home residents with dementia in the US: an analysis of National Survey Data. Drugs Aging 26: 483-492. DOI: 10.2165/00002512-200926060- 00005.
    • (2009) Drugs Aging , vol.26 , pp. 483-492
    • Kamble, P.1    Chen, H.2    Sherer, J.T.3    Aparasu, R.R.4
  • 9
    • 76749090203 scopus 로고    scopus 로고
    • Psychopharmacological neuroprotection in neurodegenerative disease: Assessing the preclinical data
    • DOI: 10.1176/appi.neuropsych.22.1.8
    • Lauterbach EC, Victoroff J, Coburn KL, et al., 2010. Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. J Neuropsychiatry Clin Neurosci 22: 8-18. DOI: 10.1176/appi.neuropsych.22.1.8.
    • (2010) J Neuropsychiatry Clin Neurosci , vol.22 , pp. 8-18
    • Lauterbach, E.C.1    Victoroff, J.2    Coburn, K.L.3
  • 10
    • 58149394415 scopus 로고    scopus 로고
    • Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease
    • DOI: 10.1523/JNEUROSCI.4218-08.2008
    • Liu Y, Yoo MJ, Savonenko A, et al., 2008. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci 28: 13805-13814. DOI: 10.1523/JNEUROSCI.4218- 08.2008.
    • (2008) J Neurosci , vol.28 , pp. 13805-13814
    • Liu, Y.1    Yoo, M.J.2    Savonenko, A.3
  • 11
    • 33845991157 scopus 로고    scopus 로고
    • Antipsychotics and cognitive decline in Alzheimer's disease: The LASER-Alzheimer's disease longitudinal study
    • DOI: 10.1136/jnnp.2006.094342
    • Livingston G, Walker AE, Katona CL, Cooper C,. 2007. Antipsychotics and cognitive decline in Alzheimer's disease: the LASER-Alzheimer's disease longitudinal study. J Neurol Neurosurg Psychiatry 78: 25-29. DOI: 10.1136/jnnp.2006.094342.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 25-29
    • Livingston, G.1    Walker, A.E.2    Katona, C.L.3    Cooper, C.4
  • 12
    • 0032844231 scopus 로고    scopus 로고
    • Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease
    • Lopez OL, Wisniewski SR, Becker JT, Boller F, DeKosky ST,. 1999. Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease. Arch Neurol 56: 1266-1272.
    • (1999) Arch Neurol , vol.56 , pp. 1266-1272
    • Lopez, O.L.1    Wisniewski, S.R.2    Becker, J.T.3    Boller, F.4    Dekosky, S.T.5
  • 13
    • 78049498243 scopus 로고    scopus 로고
    • Predicting cognitive decline in Alzheimer's disease: An integrated analysis
    • DOI: 10.1016/j.jalz.2010.04.003
    • Lopez OL, Schwam E, Cummings J, et al., 2010. Predicting cognitive decline in Alzheimer's disease: an integrated analysis. Alzheimers Dement 6: 431-439. DOI: 10.1016/j.jalz.2010.04.003.
    • (2010) Alzheimers Dement , vol.6 , pp. 431-439
    • Lopez, O.L.1    Schwam, E.2    Cummings, J.3
  • 14
    • 0032958377 scopus 로고    scopus 로고
    • The general medical health rating: A bedside global rating of medical comorbidity in patients with dementia
    • Lyketsos CG, Galik E, Steele C, et al., 1999. The general medical health rating: a bedside global rating of medical comorbidity in patients with dementia. J Am Geriatr Soc 47: 487-491.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 487-491
    • Lyketsos, C.G.1    Galik, E.2    Steele, C.3
  • 15
    • 3042660266 scopus 로고    scopus 로고
    • Implications of adult hippocampal neurogenesis in antidepressant action
    • Malberg JE,. 2004. Implications of adult hippocampal neurogenesis in antidepressant action. J Psychiatry Neurosci 29: 196-205.
    • (2004) J Psychiatry Neurosci , vol.29 , pp. 196-205
    • Malberg, J.E.1
  • 16
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, et al., 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 34: 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 17
    • 35948969826 scopus 로고    scopus 로고
    • Vascular factors predict rate of progression in Alzheimer disease
    • DOI: 10.1212/01.wnl.0000279520.59792.fe
    • Mielke MM, Rosenberg PB, Tschanz J, et al., 2007. Vascular factors predict rate of progression in Alzheimer disease. Neurology 69: 1850-1858. DOI: 10.1212/01.wnl.0000279520.59792.fe.
    • (2007) Neurology , vol.69 , pp. 1850-1858
    • Mielke, M.M.1    Rosenberg, P.B.2    Tschanz, J.3
  • 18
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): Current version and scoring rules
    • Morris JC,. 1993. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43: 2412-2414.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 19
    • 0031438475 scopus 로고    scopus 로고
    • Clinical dementia rating: A reliable and valid diagnostic and staging measure for dementia of the Alzheimer type
    • discussion 177-8
    • Morris JC,. 1997. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr 9 Suppl 1: 173-176; discussion 177-8.
    • (1997) Int Psychogeriatr , vol.91 , pp. 173-176
    • Morris, J.C.1
  • 20
    • 0030859067 scopus 로고    scopus 로고
    • Clinical dementia rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience
    • Morris JC, Ernesto C, Schafer K, et al., 1997. Clinical dementia rating training and reliability in multicenter studies: the Alzheimer's Disease Cooperative Study experience. Neurology 48: 1508-1510.
    • (1997) Neurology , vol.48 , pp. 1508-1510
    • Morris, J.C.1    Ernesto, C.2    Schafer, K.3
  • 21
    • 0347192998 scopus 로고    scopus 로고
    • Longitudinal association of initiation/perseveration and severity of geriatric depression
    • Murphy CF, Alexopoulos GS,. 2004. Longitudinal association of initiation/perseveration and severity of geriatric depression. Am J Geriatr Psychiatry 12: 50-56.
    • (2004) Am J Geriatr Psychiatry , vol.12 , pp. 50-56
    • Murphy, C.F.1    Alexopoulos, G.S.2
  • 22
    • 34247211763 scopus 로고    scopus 로고
    • Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice
    • DOI: 10.1016/j.expneurol.2007.01.037
    • Nelson RL, Guo Z, Halagappa VM, et al., 2007. Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol 205: 166-176. DOI: 10.1016/j.expneurol.2007.01.037.
    • (2007) Exp Neurol , vol.205 , pp. 166-176
    • Nelson, R.L.1    Guo, Z.2    Halagappa, V.M.3
  • 23
    • 77952421790 scopus 로고    scopus 로고
    • Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: The role of depression and apathy
    • DOI: 10.3233/JAD-2010-1352
    • Palmer K, Di Iulio F, Varsi AE, et al., 2010. Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy. J Alzheimers Dis. DOI: 10.3233/JAD-2010-1352.
    • (2010) J Alzheimers Dis
    • Palmer, K.1    Di Iulio, F.2    Varsi, A.E.3
  • 24
    • 33750492606 scopus 로고    scopus 로고
    • Influence of premorbid IQ and education on progression of Alzheimer's disease
    • DOI: 10.1159/000095640; DEM2006022004367 [pii]
    • Pavlik VN, Doody RS, Massman PJ, Chan W,. 2006. Influence of premorbid IQ and education on progression of Alzheimer's disease. Dement Geriatr Cogn Disord 22: 367-377. DOI: 10.1159/000095640; DEM2006022004367 [pii].
    • (2006) Dement Geriatr Cogn Disord , vol.22 , pp. 367-377
    • Pavlik, V.N.1    Doody, R.S.2    Massman, P.J.3    Chan, W.4
  • 25
    • 0036190759 scopus 로고    scopus 로고
    • Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    • Pollock BG, Mulsant BH, Rosen J, et al,. 2002. Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. Am J Psychiatry 159: 460-465.
    • (2002) Am J Psychiatry , vol.159 , pp. 460-465
    • Pollock, B.G.1    Mulsant, B.H.2    Rosen, J.3
  • 26
    • 42149142899 scopus 로고    scopus 로고
    • Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: A randomized, double-blind, placebo-controlled trial
    • Memantine MEM-MD-12 Study Group
    • Porsteinsson AP, Grossberg GT, Mintzer J, Olin JT, Memantine MEM-MD-12 Study Group. 2008. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial. Curr Alzheimer Res. 5: 83-89.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 83-89
    • Porsteinsson, A.P.1    Grossberg, G.T.2    Mintzer, J.3    Olin, J.T.4
  • 27
    • 75149125207 scopus 로고    scopus 로고
    • Sertraline for the treatment of depression in Alzheimer's disease
    • Rosenberg PB, Drye LT, Martin BK, et al., 2010. Sertraline for the treatment of depression in Alzheimer's disease. Am J Geriatric Psychiatry 18: 136-145.
    • (2010) Am J Geriatric Psychiatry , vol.18 , pp. 136-145
    • Rosenberg, P.B.1    Drye, L.T.2    Martin, B.K.3
  • 28
    • 77951874698 scopus 로고    scopus 로고
    • Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease
    • DOI: 10.1186/alzrt7
    • Rountree SD, Chan W, Pavlik VN, et al., 2009. Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease. Alzheimers Res Ther 1: 7. DOI: 10.1186/alzrt7.
    • (2009) Alzheimers Res Ther , vol.1 , pp. 7
    • Rountree, S.D.1    Chan, W.2    Pavlik, V.N.3
  • 29
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials
    • DOI: 10.1001/jama.294.15.1934
    • Schneider LS, Dagerman KS, Insel P,. 2005. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 294: 1934-1943. DOI: 10.1001/jama.294.15.1934.
    • (2005) JAMA , vol.294 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 30
    • 66549103973 scopus 로고    scopus 로고
    • Association of antipsychotic use with hospital events and mortality among medicare beneficiaries residing in long-term care facilities
    • DOI: 10.1097/JGP.0b013e31819b8936
    • Simoni-Wastila L, Ryder PT, Qian J, et al., 2009. Association of antipsychotic use with hospital events and mortality among medicare beneficiaries residing in long-term care facilities. Am J Geriatr Psychiatry 17: 417-427. DOI: 10.1097/JGP.0b013e31819b8936.
    • (2009) Am J Geriatr Psychiatry , vol.17 , pp. 417-427
    • Simoni-Wastila, L.1    Ryder, P.T.2    Qian, J.3
  • 31
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence
    • DOI: 10.1001/jama.293.5.596
    • Sink KM, Holden KF, Yaffe K,. 2005. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA 293: 596-608. DOI: 10.1001/jama.293.5.596.
    • (2005) JAMA , vol.293 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 32
    • 39749127211 scopus 로고    scopus 로고
    • Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: The Cache County Study
    • DOI: 10.1002/gps.1858
    • Steinberg M, Shao H, Zandi P, et al., 2008. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry 23: 170-177. DOI: 10.1002/gps.1858.
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 170-177
    • Steinberg, M.1    Shao, H.2    Zandi, P.3
  • 33
    • 46749095495 scopus 로고    scopus 로고
    • Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: Phase 1 outcomes from the CATIE-AD effectiveness trial
    • DOI: 10.1176/appi.ajp.2008.07111779
    • Sultzer DL, Davis SM, Tariot PN, et al., 2008. Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: phase 1 outcomes from the CATIE-AD effectiveness trial. Am J Psychiatry 165: 844-854. DOI: 10.1176/appi.ajp.2008.07111779.
    • (2008) Am J Psychiatry , vol.165 , pp. 844-854
    • Sultzer, D.L.1    Davis, S.M.2    Tariot, P.N.3
  • 34
    • 79958813690 scopus 로고    scopus 로고
    • Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: The Cache County Dementia Progression Study
    • DOI: 10.1097/JGP.0b013e3181faec23
    • Tschanz JT, Corcoran CD, Schwartz S, et al., 2011. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression Study. Am J Geriatr Psychiatry 19: 532-542. DOI: 10.1097/JGP.0b013e3181faec23.
    • (2011) Am J Geriatr Psychiatry , vol.19 , pp. 532-542
    • Tschanz, J.T.1    Corcoran, C.D.2    Schwartz, S.3
  • 35
    • 28244431743 scopus 로고    scopus 로고
    • Risk of death in elderly users of conventional vs. atypical antipsychotic medications
    • DOI: 10.1056/NEJMoa052827
    • Wang PS, Schneeweiss S, Avorn J, et al., 2005. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 353: 2335-2341. DOI: 10.1056/NEJMoa052827.
    • (2005) N Engl J Med , vol.353 , pp. 2335-2341
    • Wang, P.S.1    Schneeweiss, S.2    Avorn, J.3
  • 36
    • 45249087489 scopus 로고    scopus 로고
    • Functional consequences of locus coeruleus degeneration in Alzheimer's disease
    • Weinshenker D,. 2008. Functional consequences of locus coeruleus degeneration in Alzheimer's disease. Curr Alzheimer Res 5: 342-345.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 342-345
    • Weinshenker, D.1
  • 37
    • 77949511377 scopus 로고    scopus 로고
    • Sertraline for the treatment of depression in Alzheimer disease: Week-24 outcomes
    • DOI: 10.1097/JGP.0b013e3181cc0333
    • Weintraub D, Rosenberg PB, Drye LT, et al., 2010. Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry 18: 332-340. DOI: 10.1097/JGP.0b013e3181cc0333.
    • (2010) Am J Geriatr Psychiatry , vol.18 , pp. 332-340
    • Weintraub, D.1    Rosenberg, P.B.2    Drye, L.T.3
  • 38
    • 73249116989 scopus 로고    scopus 로고
    • Meta-analysis of the impact of 9 medication classes on falls in elderly persons
    • DOI: 10.1001/archinternmed.2009.357
    • Woolcott JC, Richardson KJ, Wiens MO, et al., 2009. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 169: 1952-1960. DOI: 10.1001/archinternmed.2009.357.
    • (2009) Arch Intern Med , vol.169 , pp. 1952-1960
    • Woolcott, J.C.1    Richardson, K.J.2    Wiens, M.O.3
  • 39
    • 0037167542 scopus 로고    scopus 로고
    • Reduced incidence of AD with NSAID but not H2 receptor antagonists: The Cache County Study
    • Zandi PP, Anthony JC, Hayden KM, et al., 2002. Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 59: 880-886.
    • (2002) Neurology , vol.59 , pp. 880-886
    • Zandi, P.P.1    Anthony, J.C.2    Hayden, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.