Do treatment effects vary among differing baseline depression criteria in depression in alzheimer's disease study ± 2 (DIADS-2)?

International Journal of Geriatric Psychiatry

Volumn 26, Issue 6, 2011, Pages 573-583

  Drye, Lea T ^a   Martin, Barbara K ^a   Frangakis, Constantine E ^a   Meinert, Curtis L ^a   Mintzer, Jacobo E ^b   Munro, Cynthia A ^c   Porsteinsson, Anton P ^d   Rabins, Peter V ^c   Rosenberg, Paul B ^c   Schneider, Lon S ^e   Weintraub, Daniel ^f   Lyketsos, Constantine G ^c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's dementia; depression; randomized trial; sertraline

Indexed keywords

PLACEBO; SERTRALINE;

ALZHEIMER DISEASE; ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD DISORDER; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PSYCHIATRIC STATUS RATING SCALES; SEROTONIN UPTAKE INHIBITORS; SERTRALINE;

EID: 79953819258     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2565     Document Type: Article

References (26)

1. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA,. 1988. Cornell Scale for Depression in Dementia. Biol Psychiatry 23 (3): 271-284. (Pubitemid 18047596)
2. American Psychiatric Association. 2000. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC.
3. Folstein MF, Folstein SE, McHugh PR,. 1975. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 196-198.
4. Fournier JC, DeRubeis RJ, Hollon SD, et al,. 2010. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 303 (1): 47-53.
5. Lee HB, Lyketsos CG,. 2003. Depression in Alzheimer's disease: heterogeneity and related issues. Biol Psychiatry 54 (3): 353-362. (Pubitemid 37270616)
6. Lyketsos CG, Sheppard JM, Steele CD, et al,. 2000. Randomized, placebo-controlled, double-blind clinical trial of sertraline in the treatment of depression complicating Alzheimer's disease: initial results from the Depression in Alzheimer's Disease study. Am J Psychiatry 157 (10): 1686-1689.
7. Lyketsos CG, Breitner JC, Rabins PV,. 2001. An evidence-based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease. Int J Geriatr Psychiatry 16 (11): 1037-1042. (Pubitemid 33089267)
8. Lyketsos CG, Lopez O, Jones B, et al,. 2002. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 288 (12): 1475-1483.
9. Lyketsos CG, DelCampo L, Steinberg M, et al,. 2003. Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry 60 (7): 737-746. (Pubitemid 36818637)
10. Magai C, Kennedy G, Cohen CI, Gomberg D,. 2000. A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease. Am J Geriatr Psychiatry 8 (1): 66-74. (Pubitemid 30036843)
11. Martin BK, Frangakis CE, Rosenberg PB, et al,. 2006. Design of Depression in Alzheimer's Disease Study-2. Am J Geriatr Psychiatry 14 (11): 920-930. (Pubitemid 44706410)
12. National Institute for Clinical Excellence. 2004. Depression: management of depression in primary and secondary care. Clinical practice guideline No 23. In National Institute for Clinical Excellence.
13. Nelson JC, Delucchi K, Schneider LS,. 2008. Efficacy of second generation antidepressants in late-life depression: a meta-analysis of the evidence. Am J Geriatr Psychiatry 16 (7): 558-567.
14. Olin JT, Katz IR, Meyers BS, Schneider LS, Lebowitz BD,. 2002. Provisional diagnostic criteria for depression of Alzheimer disease: rationale and background. Am J Geriatr Psychiatry 10 (2): 129-141.
15. Petracca GM, Chemerinski E, Starkstein SE,. 2001. A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease. Int Psychogeriatr 13 (2): 233-240. (Pubitemid 32703334)
16. Petracca G, Teson A, Chemerinski E, Leiguarda R, Starkstein SE,. 1996. A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease. J Neuropsychiatry Clin Neurosci 8 (3): 270-275. (Pubitemid 26275737)
17. R Development Core Team. 2009. R: A language and environment for statistical computing. In R Foundation for Statistical Computing: Vienna, Austria.
18. Reifler BV, Teri L, Raskind M, et al,. 1989. Double-blind trial of imipramine in Alzheimer's disease patients with and without depression. Am J Psychiatry 146 (1): 45-49. (Pubitemid 19033221)
19. Rosenberg PB, Onyike CU, Katz IR, et al,. 2005. Clinical application of operationalized criteria for 'Depression of Alzheimer's Disease'. Int J Geriatr Psychiatry 20 (2): 119-127. (Pubitemid 40277890)
20. Rosenberg PB, Drye LT, Martin BK, et al,. 2010. Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry 18 (2): 136-145.
21. Roth M, Mountjoy CQ, Amrein R,. 1996. Moclobemide in elderly patients with cognitive decline and depression: an international double-blind, placebo-controlled trial. Br J Psychiatry 168 (2): 149-157.
22. Rubin DB,. 1996a. Multiple Imputation for Nonresponse in Surveys. John Wiley & Sons: New York.
23. Rubin DB,. 1996b. Multiple imputation after 18+ years. J Am Stat Assoc 91: 473-489.
24. Schneider LS, Olin JT, Doody RS, et al,. 1997. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11 (Suppl 2): S22-S32.
25. Steinberg M, Shao H, Zandi P, et al,. 2008. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry 23 (2): 170-177. (Pubitemid 351308497)
26. Weintraub D, Rosenberg PB, Drye LT, et al,. 2010. Sertraline for the treatment of depression in Alzheimer's disease: Week-24 outcomes. Am J Geriatr Psychiatry 18 (4): 332-340.