HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development

Development (Cambridge)

Volumn 139, Issue 23, 2012, Pages 4473-4483

  Bentovim, Lital ^a   Amarilio, Roy ^a   Zelzer, Elazar ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Bone development; Chondrocytes; Collagen; cP4H; ER stress; Extracellular matrix; Growth plate; HIF1 and alpha; ; Hydroxylation; Hypoxia; Mouse; Pdk1; Secretion

Indexed keywords

COLLAGEN TYPE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PYRUVATE DEHYDROGENASE KINASE;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CATALYSIS; CELL FUNCTION; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRIX; GENE INDUCTION; GENETIC TRANSCRIPTION; GROWTH PLATE; HOMEOSTASIS; HYDROXYLATION; HYPOXIA; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; CITRIC ACID CYCLE; COLLAGEN; ENDOPLASMIC RETICULUM; GROWTH PLATE; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES;

EID: 84868577455     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.083881     Document Type: Article

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