Peroxisome proliferator-activated receptor γ b cell-specific- deficient mice have an impaired antibody response

Journal of Immunology

Volumn 189, Issue 10, 2012, Pages 4740-4747

  Ramon, Sesquile ^a   Bancos, Simona ^a   Thatcher, Thomas H ^a   Murant, Thomas I ^a   Moshkani, Safiehkhatoon ^a   Sahler, Julie M ^a   Bottaro, Andrea ^a   Sime, Patricia J ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BCL 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN DETECTION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BLOOD LEVEL; CELL INTERACTION; CELL MATURATION; CELL SPECIFICITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SECRETORY CELL;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PLASMA CELLS; PPAR GAMMA; TRANSCRIPTION FACTORS;

EID: 84868565513     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200956     Document Type: Article

References (44)

1. Braissant, O., F. Foufelle, C. Scotto, M. Dauça, and W. Wahli. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha,-beta, and-gamma in the adult rat. Endocrinology 137: 354-366.
2. Glass, C. K., and S. Ogawa. 2006. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat. Rev. Immunol. 6: 44-55.
3. Ward, J. E., and X. Tan. 2007. Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease. PPAR Res. 2007: 14983.
4. Kuzuya, T., Y. Iwamoto, K. Kosaka, K. Takebe, T. Yamanouchi, M. Kasuga, H. Kajinuma, Y. Akanuma, S. Yoshida, Y. Shigeta, et al. 1991. A pilot clinical trial of a new oral hypoglycemic agent, CS-045, in patients with non-insulin dependent diabetes mellitus. Diabetes Res. Clin. Pract. 11: 147-153.
5. Chang, A. Y., B. M. Wyse, B. J. Gilchrist, T. Peterson, and A. R. Diani. 1983. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32: 830-838.
6. Farrow, S. N. 2008. Nuclear receptors: doubling up in the lung. Curr. Opin. Pharmacol. 8: 275-279.
7. Kulkarni, A. A., T. H. Thatcher, K. C. Olsen, S. B. Maggirwar, R. P. Phipps, and P. J. Sime. 2011. PPAR-g ligands repress TGFb-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS ONE 6: e15909.
8. Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270: 12953-12956.
9. Barak, Y., M. C. Nelson, E. S. Ong, Y. Z. Jones, P. Ruiz-Lozano, K. R. Chien, A. Koder, and R. M. Evans. 1999. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 4: 585-595.
10. Rosen, E. D., P. Sarraf, A. E. Troy, G. Bradwin, K. Moore, D. S. Milstone, B. M. Spiegelman, and R. M. Mortensen. 1999. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4: 611-617.
11. Nagy, L., P. Tontonoz, J. G. Alvarez, H. Chen, and R. M. Evans. 1998. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93: 229-240.
12. Faveeuw, C., S. Fougeray, V. Angeli, J. Fontaine, G. Chinetti, P. Gosset, P. Delerive, C. Maliszewski, M. Capron, B. Staels, et al. 2000. Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. FEBS Lett. 486: 261-266.
13. Gosset, P., A. S. Charbonnier, P. Delerive, J. Fontaine, B. Staels, J. Pestel, A. B. Tonnel, and F. Trottein. 2001. Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells. Eur. J. Immunol. 31: 2857-2865.
14. Padilla, J., E. Leung, and R. P. Phipps. 2002. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. Clin. Immunol. 103: 22-33.
15. Tontonoz, P., L. Nagy, J. G. Alvarez, V. A. Thomazy, and R. M. Evans. 1998. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93: 241-252.
16. Cunard, R., M. Ricote, D. DiCampli, D. C. Archer, D. A. Kahn, C. K. Glass, and C. J. Kelly. 2002. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J. Immunol. 168: 2795-2802.
17. Harris, S. G., and R. P. Phipps. 2002. Prostaglandin D(2), its metabolite 15-d-PGJ (2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. Immunology 105: 23-34.
18. Harris, S. G., and R. P. Phipps. 2002. Induction of apoptosis in mouse T cells upon peroxisome proliferator-activated receptor gamma (PPAR-gamma) binding. Adv. Exp. Med. Biol. 507: 421-425.
19. Schmidlin, H., S. A. Diehl, and B. Blom. 2009. New insights into the regulation of human B-cell differentiation. Trends Immunol. 30: 277-285.
20. Klein, U., and R. Dalla-Favera. 2008. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8: 22-33.
21. Garcia-Bates, T. M., C. J. Baglole, M. P. Bernard, T. I. Murant, P. J. Simpson-Haidaris, and R. P. Phipps. 2009. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J. Immunol. 183: 6903-6912.
22. Garcia-Bates, T. M., S. H. Bernstein, and R. P. Phipps. 2008. Peroxisome proliferator-activated receptor gamma overexpression suppresses growth and induces apoptosis in human multiple myeloma cells. Clin. Cancer Res. 14: 6414-6425.
23. Garcia-Bates, T. M., S. A. Peslak, C. J. Baglole, S. B. Maggirwar, S. H. Bernstein, and R. P. Phipps. 2009. Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lym-phoma proliferation and survival. Cancer Immunol. Immunother. 58: 1071-1083.
24. Padilla, J., K. Kaur, H. J. Cao, T. J. Smith, and R. P. Phipps. 2000. Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14) (12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J. Immunol. 165: 6941-6948.
25. Setoguchi, K., Y. Misaki, Y. Terauchi, T. Yamauchi, K. Kawahata, T. Kadowaki, and K. Yamamoto. 2001. Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis. J. Clin. Invest. 108: 1667-1675.
26. Akiyama, T. E., S. Sakai, G. Lambert, C. J. Nicol, K. Matsusue, S. Pimprale, Y. H. Lee, M. Ricote, C. K. Glass, H. B. Brewer, Jr., and F. J. Gonzalez. 2002. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol. Cell. Biol. 22: 2607-2619.
27. Srinivas, S., T. Watanabe, C. S. Lin, C. M. William, Y. Tanabe, T. M. Jessell, and F. Costantini. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1: 4.
28. Miyauchi, Y., K. Ninomiya, H. Miyamoto, A. Sakamoto, R. Iwasaki, H. Hoshi, K. Miyamoto, W. Hao, S. Yoshida, H. Morioka, et al. 2010. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J. Exp. Med. 207: 751-762.
29. Hardy, R. R., P. W. Kincade, and K. Dorshkind. 2007. The protean nature of cells in the B lymphocyte lineage. Immunity 26: 703-714.
30. Rickert, R. C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25: 1317-1318.
31. Allman, D., and S. Pillai. 2008. Peripheral B cell subsets. Curr. Opin. Immunol. 20: 149-157.
32. Hardy, R. R., and K. Hayakawa. 2001. B cell development pathways. Annu. Rev. Immunol. 19: 595-621.
33. Garcia-Bates, T. M., G. M. Lehmann, P. J. Simpson-Haidaris, S. H. Bernstein, P. J. Sime, and R. P. Phipps. 2008. Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res. 2008: 834612.
34. Vinuesa, C. G., and J. G. Cyster. 2011. How T cells earn the follicular rite of passage. Immunity 35: 671-680.
35. McHeyzer-Williams, L. J., D. J. Driver, and M. G. McHeyzer-Williams. 2001. Germinal center reaction. Curr. Opin. Hematol. 8: 52-59.
36. Dent, A. L., A. L. Shaffer, X. Yu, D. Allman, and L. M. Staudt. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589-592.
37. Ye, B. H., G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, R. S. Chaganti, et al. 1997. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16: 161-170.
38. Lin, K. I., C. Angelin-Duclos, T. C. Kuo, and K. Calame. 2002. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to im-munoglobulin M-secreting plasma cells. Mol. Cell. Biol. 22: 4771-4780.
39. Crotty, S., R. J. Johnston, and S. P. Schoenberger. 2010. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat. Immunol. 11: 114-120.
40. Saito, M., J. Gao, K. Basso, Y. Kitagawa, P. M. Smith, G. Bhagat, A. Pernis, L. Pasqualucci, and R. Dalla-Favera. 2007. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 12: 280-292.
41. Calame, K. 2008. Activation-dependent induction of Blimp-1. Curr. Opin. Immunol. 20: 259-264.
42. Ricote, M., and C. K. Glass. 2007. PPARs and molecular mechanisms of transrepression. Biochim. Biophys. Acta 1771: 926-935.
43. Kawahito, Y., M. Kondo, Y. Tsubouchi, A. Hashiramoto, D. Bishop-Bailey, K. Inoue, M. Kohno, R. Yamada, T. Hla, and H. Sano. 2000. 15-deoxy-delta (12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J. Clin. Invest. 106: 189-197.
44. Robertshaw, H., and P. S. Friedmann. 2005. Pioglitazone: a promising therapy for psoriasis. Br. J. Dermatol. 152: 189-191.