Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates

Journal of Controlled Release

Volumn 164, Issue 1, 2012, Pages 65-73

  Deshmukh, Manjeet ^a,b   Kutscher, Hilliard L ^a   Gao, Dayuan ^a,b   Sunil, Vasanthi R ^a,b   Malaviya, Rama ^a,b   Vayas, Kinal ^a,b   Stein, Stanley ^a,b   Laskin, Jeffrey D ^b,c   Laskin, Debra L ^a,b   Sinko, Patrick J ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Biodegradable microparticle; Drug delivery system; Nanogel aggregates; Passive pulmonary targeting; Poly(ethylene glycol)

Indexed keywords

BIODISTRIBUTIONS; COULTER COUNTERS; DRUG DELIVERY SYSTEM; EX VIVO IMAGING; HISTOLOGICAL EVALUATION; LUNG CANCER; MICRO PARTICLES; NANOGELS; PASSIVE PULMONARY TARGETING; PHOSPHATE BUFFERS; PHOSPHATE-BUFFERED SALINES; PRINCIPLE COMPONENT; RAT PLASMA; RENAL CLEARANCE; SPRAGUE-DAWLEY RATS; STABILITY STUDY; TRANSMISSION ELECTRON MICROSCOPY TEM;

AGGREGATES; BIOLOGICAL ORGANS; BODY FLUIDS; DISEASES; DRUG DELIVERY; FLUORSPAR; HEXANE; NANOSTRUCTURED MATERIALS; POLYETHYLENE GLYCOLS; SYNTHESIS (CHEMICAL); TRANSMISSION ELECTRON MICROSCOPY;

AGGLOMERATION;

DYE; MACROGOL; NANOMATERIAL; NANOPARTICLE; PHOSPHATE BUFFERED SALINE; POLYSORBATE 80; STABILIZED AGGREGATED NANOGEL PARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; COULTER COUNTER; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TARGETING; GEL; GLOMERULUS FILTRATION; HISTOLOGY; IMAGING; KIDNEY CLEARANCE; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; INJECTIONS, INTRAVENOUS; KIDNEY; LUNG; MALE; METABOLIC CLEARANCE RATE; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 84868506248     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.09.011     Document Type: Article

References (50)

1. P. Chao, M. Deshmukh, H.L. Kutscher, D. Gao, S.S. Rajan, P. Hu, D.L. Laskin, S. Stein, and P.J. Sinko Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model Anticancer Drugs 21 2010 65 76
2. H.L. Kutscher, P. Chao, M. Deshmukh, Y. Singh, P. Hu, L.B. Joseph, D.C. Reimer, S. Stein, D.L. Laskin, and P.J. Sinko Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats J. Control. Release 143 2010 31 37
3. D.A. Norris, N. Puri, and P.J. Sinko The effect of physical barriers and properties on the oral absorption of particulates Adv. Drug Deliv. Rev. 34 1998 135 154
4. D.A. Norris, and P.J. Sinko Effect of size, surface charge and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin J. Appl. Polym. Sci. 63 1997 1481 1492
5. B.N. Halpern, B. Benacerraf, and G. Biozzi Quantitative study of the granulopectic activity of the reticulo-endothelial system. I. The effect of the ingredients present in India ink and of substances affecting blood clotting in vivo on the fate of carbon particles administered intravenously in rats, mice and rabbits Br. J. Exp. Pathol. 34 1953 426 440
6. W.E. Stehbens, and H.W. Florey The behavior of intravenously injected particles observed in chambers in rabbits' ears Q. J. Exp. Physiol. Cogn. Med. Sci. 45 1960 252 264
7. M. Kanke, G.H. Simmons, D.L. Weiss, B.A. Bivins, and P.P. DeLuca Clearance of 141C3-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs J. Pharm. Sci. 69 1980 755 762
8. H.G. Schroeder, G.H. Simmons, and P.P. DeLuca Distribution of radiolabeled subvisible microspheres after intravenous administration to beagle dogs J. Pharm. Sci. 67 1978 504 507
9. J.D. Slack, M. Kanke, G.H. Simmons, and P.P. DeLuca Acute hemodynamic effects and blood pool kinetics of polystyrene microspheres following intravenous administration J. Pharm. Sci. 70 1981 660 664
10. M.R. Green, G.M. Manikhas, S. Orlov, B. Afanasyev, A.M. Makhson, P. Bhar, and M.J. Hawkins Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer Ann. Oncol. 17 2006 1263 1268
11. N. Puri, E.H. Weyand, S.M. Abdel-Rahman, and P.J. Sinko An investigation of the intradermal route as an effective means of immunization for microparticulate vaccine delivery systems Vaccine 18 2000 2600 2612
12. N.A. Rizvi, G.J. Riely, C.G. Azzoli, V.A. Miller, K.K. Ng, J. Fiore, G. Chia, M. Brower, R. Heelan, M.J. Hawkins, and M.G. Kris Phase I/II trial of weekly intravenous 130-nm albumin-bound paclitaxel as initial chemotherapy in patients with stage IV non-small-cell lung cancer J. Clin. Oncol. 26 2008 639 643
13. K. Santhi, S.A. Dhanaraj, M. Koshy, S. Ponnusankar, and B. Suresh Study of biodistribution of methotrexate-loaded bovine serum albumin nanospheres in mice Drug Dev. Ind. Pharm. 26 2000 1293 1296
14. A. Delgado, I. Soriano, E. Sanchez, M. Oliva, and C. Evora Radiolabelled biodegradable microspheres for lung imaging Eur. J. Pharm. Biopharm. 50 2000 227 236
15. F.M. Orson, B.M. Kinsey, P.J. Hua, B.S. Bhogal, C.L. Densmore, and M.A. Barry Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses J. Immunol. 164 2000 6313 6321
16. L.G. Colombetti, S. Moerlien, and S. Pinsky Rapid and reliable preparation of macroaggregated albumin suitable for lung scintigraphy Int. J. Nucl. Med. Biol. 2 1975 180 184
17. G.L. DeNardo, D.A. Goodwin, R. Ravasini, and P.A. Dietrich The ventilatory lung scan in the diagnosis of pulmonary embolism N. Engl. J. Med. 282 1970 1334 1336
18. E.J. Hapke, and H.J. Pederson Ultrastructural changes in rat lungs induced by radioactive macroaggregated albumin Am. Rev. Respir. Dis. 100 1969 194 205
19. H.L. Kutscher, P. Chao, M. Deshmukh, S. Sundara Rajan, Y. Singh, P. Hu, L.B. Joseph, S. Stein, D.L. Laskin, and P.J. Sinko Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats Int. J. Pharm. 402 2010 64 71
20. M. Deshmukh, P. Chao, H.L. Kutscher, D. Gao, and P.J. Sinko A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity J. Med. Chem. 53 2010 1038 1047
21. P. Caliceti, and F.M. Veronese Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates Adv. Drug Deliv. Rev. 55 2003 1261 1277
22. T. Yamaoka, Y. Tabata, and Y. Ikada Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice J. Pharm. Sci. 83 1994 601 606
23. W. Kunz, P. Lo Nostro, and B.W. Ninham The present state of affairs with Hofmeister effects Curr. Opin. Colloid Interface Sci. 9 2004 1 18
24. V.A. Parsegian Hopes for Hofmeister Nature 378 1995 335 336
25. S. Förster, and M. Antonietti Amphiphilic block copolymers in structure-controlled nanomaterial hybrids Adv. Mater. 10 1998 195 217
26. S. Mandal, S. Phadtare, and M. Sastry Interfacing biology with nanoparticles J. Appl. Phys. 5 2005 118 127
27. K. Akiyoshi, S. Deguchi, N. Moriguchi, S. Yamaguchi, and J. Sunamoto Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles Macromolecules 26 1993 3062 3068
28. S.M. Kuo, G.-C. Niu, S.J. Chang, C.H. Kuo, and M.S. Bair A one-step method for fabricating chitosan microspheres J. Appl. Polym. Sci. 94 2004 2150 2157
29. F. Zhao, Y. Zhao, Y. Liu, X. Chang, and C. Chen Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials Small 7 2011 1322 1337
30. A.A. Warren, and C.W. Chan Effect of gold nanoparticle aggregation on cell uptake and toxicity ACS Nano 5 2011 5478 5489
31. B. Elsadek, and F. Kratz Impact of albumin on drug delivery - new applications on the horizon J. Control. Release 157 2012 4 28
32. E.R. Weibel Morphometry of the Human Lung 1963 Springer Berlin
33. V.E. Krahl Pulmonary Embolic Disease M.S.A. Sasahara, 1965 Grune and Stratton New York
34. A.C. Short, M.L. Montoya, S.A. Gebb, R.G. Presson Jr., W.W. Wagner Jr., and R.L. Capen Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks J. Appl. Physiol. 80 1996 1568 1573
35. A.F. Yapel Albumin microspheres: heat and chemical stabilization Methods Enzymol. 112 1985 3 18U
36. M.A. Davis Particulate Radiopharm aceuticals for Pulmonary Studies G. Subramanian, Radiopharmaceuticals 1975 Society of Nuclear Medicine New York 267 281
37. B.A. Scheffel, T.K. Rhodes, H.N. Natarajan, and J. Wagner Albumin microspheres for study of the reticuloendothelial system J. Nucl. Med. 13 1972 498 503
38. H.L. Chia Particulate radiopharmaceuticals in nuclear medicine P.H. Cox, Radiopharmacy & Radiopharmacology Year book 2 1987 Gordon and Breach Science NewYork 1 77
39. H.S. Choi, W. Liu, P. Misra, E. Tanaka, J.P. Zimmer, B. Itty Ipe, M.G. Bawendi, and J.V. Frangioni Renal clearance of quantum dots Nat. Biotechnol. 25 2007 1165 1170
40. R.F. Wideman Jr., and G.F. Erf Intravenous micro-particle injection and pulmonary hypertension in broiler chickens: cardio-pulmonary hemodynamic responses Poult. Sci. 81 2002 877 886
41. B.D. Mather, K. Viswanathan, K.M. Miller, and T.E. Long Michael addition reactions in macromolecular design for emerging technologies Prog. Polym. Sci. 31 2006 487 531
42. M.J. Roberts, M.D. Bentley, and J.M. Harris Chemistry for peptide and protein PEGylation Adv. Drug Deliv. Rev. 54 2002 459 476
43. M. Morpurgo, F.M. Veronese, D. Kachensky, and J.M. Harris Preparation and characterization of poly(ethylene glycol) vinyl sulfone Bioconjug. Chem. 7 1996 363 368
44. H. Maeda, G.Y. Bharate, and J. Daruwalla Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect Eur. J. Pharm. Biopharm. 71 2009 409 419
45. P.G. Zerefos, K. Vougas, P. Dimitraki, S. Kossida, A. Petrolekas, K. Stravodimos, A. Giannopoulos, M. Fountoulakis, and A. Vlahou Characterization of the human urine proteome by preparative electrophoresis in combination with 2-DE Proteomics 6 2006 4346 4355
46. S.G. Levesque, and M.S. Shoichet Synthesis of enzyme-degradable, peptide-cross-linked dextran hydrogels Bioconjug. Chem. 18 2007 874 885
47. K.J. Greenlee, Z. Werb, and F. Kheradmand Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted Physiol. Rev. 87 2007 69 98
48. S. Buckley, B. Driscoll, W. Shi, K. Anderson, and D. Warburton Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells Am. J. Physiol. Lung Cell. Mol. Physiol. 281 2001 L427 434
49. R.P. Lemke, W. Zhang, D. Balcerazak, K. Kobayashi, A. Schwingshackl, P.Y. Cheung, W.T. Dixon, V.E. Baracos, and J.J. Greer Expression and activity of matrix metallo proteinases 2 and 9 and their inhibitors in rat lungs during the perinatal period and in diaphragmatic hernia Exp. Lung Res. 29 2003 261 276
50. K. Masumoto, J.D. de Rooij, S. Suita, R. Rottier, D. Tibboel, and R.R. de Krijger Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development Histopathology 47 2005 410 419