메뉴 건너뛰기




Volumn 365, Issue 1, 2013, Pages 64-74

Microtubule network is required for insulin-induced signal transduction and actin remodeling

Author keywords

Actin; Insulin signal transduction; Microtubule

Indexed keywords

ACTIN; ALPHA TUBULIN; F ACTIN; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ZETA; TYROSINE;

EID: 84868504841     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.09.005     Document Type: Article
Times cited : (16)

References (55)
  • 1
    • 0030812546 scopus 로고    scopus 로고
    • Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
    • Bandyopadhyay G., Standaert M.L., Galloway L., Moscat J., Farese R.V. Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology 1997, 138:4721-4731.
    • (1997) Endocrinology , vol.138 , pp. 4721-4731
    • Bandyopadhyay, G.1    Standaert, M.L.2    Galloway, L.3    Moscat, J.4    Farese, R.V.5
  • 2
    • 0037036373 scopus 로고    scopus 로고
    • Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway
    • Brandt D., Gimona M., Hillmann M., Haller H., Mischak H. Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway. J. Biol. Chem. 2002, 277:20903-20910.
    • (2002) J. Biol. Chem. , vol.277 , pp. 20903-20910
    • Brandt, D.1    Gimona, M.2    Hillmann, M.3    Haller, H.4    Mischak, H.5
  • 3
    • 4644260677 scopus 로고    scopus 로고
    • Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues
    • Brozinick J.T., Hawkins E.D., Strawbridge A.B., Elmendorf J.S. Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues. J. Biol. Chem. 2004, 279:40699-40706.
    • (2004) J. Biol. Chem. , vol.279 , pp. 40699-40706
    • Brozinick, J.T.1    Hawkins, E.D.2    Strawbridge, A.B.3    Elmendorf, J.S.4
  • 5
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp 70 S6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham B., Vlahos C.J., Cheatham L., Wang L., Blenis J., Kahn C.R. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp 70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 1994, 14:4902-4911.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 6
    • 2442497058 scopus 로고    scopus 로고
    • Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells
    • Chen W.F., Wong M.S. Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells. J. Clin. Endocrinol. Metab. 2004, 89:2351-2359.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2351-2359
    • Chen, W.F.1    Wong, M.S.2
  • 7
    • 38549177315 scopus 로고    scopus 로고
    • A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation
    • Chen Y., Wang Y., Ji W., Xu P., Xu T. A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation. FEBS J. 2008, 275:705-712.
    • (2008) FEBS J. , vol.275 , pp. 705-712
    • Chen, Y.1    Wang, Y.2    Ji, W.3    Xu, P.4    Xu, T.5
  • 9
    • 0032211844 scopus 로고    scopus 로고
    • Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    • Corvera S., Czech M.P. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol. 1998, 8:442-446.
    • (1998) Trends Cell Biol. , vol.8 , pp. 442-446
    • Corvera, S.1    Czech, M.P.2
  • 11
    • 0035815710 scopus 로고    scopus 로고
    • A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes
    • Emoto M., Langille S.E., Czech M.P. A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J. Biol. Chem. 2001, 276:10677-10682.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10677-10682
    • Emoto, M.1    Langille, S.E.2    Czech, M.P.3
  • 12
    • 0034532975 scopus 로고    scopus 로고
    • Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake
    • Fletcher L.M., Welsh G.I., Oatey P.B., Tavare J.M. Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake. Biochem. J. 2000, 352(Pt 2):267-276.
    • (2000) Biochem. J. , vol.352 , Issue.PART 2 , pp. 267-276
    • Fletcher, L.M.1    Welsh, G.I.2    Oatey, P.B.3    Tavare, J.M.4
  • 13
    • 33749489511 scopus 로고    scopus 로고
    • Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane
    • Gonzalez E., McGraw T.E. Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Mol. Biol. Cell 2006, 17:4484-4493.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4484-4493
    • Gonzalez, E.1    McGraw, T.E.2
  • 14
    • 0032514880 scopus 로고    scopus 로고
    • Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts
    • Guadagno T.M., Ferrell J.E. Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. Science 1998, 282:1312-1315.
    • (1998) Science , vol.282 , pp. 1312-1315
    • Guadagno, T.M.1    Ferrell, J.E.2
  • 15
    • 0642376906 scopus 로고    scopus 로고
    • Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions
    • Hirai T., Chida K. Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. J. Biochem. 2003, 133:1-7.
    • (2003) J. Biochem. , vol.133 , pp. 1-7
    • Hirai, T.1    Chida, K.2
  • 17
    • 0037151026 scopus 로고    scopus 로고
    • A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
    • Kane S., Sano H., Liu S.C., Asara J.M., Lane W.S., Garner C.C., Lienhard G.E. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 2002, 277:22115-22118.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22115-22118
    • Kane, S.1    Sano, H.2    Liu, S.C.3    Asara, J.M.4    Lane, W.S.5    Garner, C.C.6    Lienhard, G.E.7
  • 18
    • 0035834644 scopus 로고    scopus 로고
    • Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling
    • Kanzaki M., Pessin J.E. Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling. J. Biol. Chem. 2001, 276:42436-42444.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42436-42444
    • Kanzaki, M.1    Pessin, J.E.2
  • 19
    • 33749472634 scopus 로고    scopus 로고
    • Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival
    • Karst A.M., Dai D.L., Cheng J.Q., Li G. Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer Res. 2006, 66:9221-9226.
    • (2006) Cancer Res. , vol.66 , pp. 9221-9226
    • Karst, A.M.1    Dai, D.L.2    Cheng, J.Q.3    Li, G.4
  • 20
    • 0033962410 scopus 로고    scopus 로고
    • Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
    • Khayat Z.A., Tong P., Yaworsky K., Bloch R.J., Klip A. Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes. J. Cell Sci. 2000, 113(Pt 2):279-290.
    • (2000) J. Cell Sci. , vol.113 , Issue.PART 2 , pp. 279-290
    • Khayat, Z.A.1    Tong, P.2    Yaworsky, K.3    Bloch, R.J.4    Klip, A.5
  • 21
    • 0020476679 scopus 로고
    • Hexose transport in L6 muscle cells. Kinetic properties and the number of [3H]cytochalasin B binding sites
    • Klip A., Logan W.J., Li G. Hexose transport in L6 muscle cells. Kinetic properties and the number of [3H]cytochalasin B binding sites. Biochim. Biophys. Acta 1982, 687:265-280.
    • (1982) Biochim. Biophys. Acta , vol.687 , pp. 265-280
    • Klip, A.1    Logan, W.J.2    Li, G.3
  • 22
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn A.D., Summers S.A., Birnbaum M.J., Roth R.A. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 1996, 271:31372-31378.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31372-31378
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 23
    • 54549102288 scopus 로고    scopus 로고
    • Beyond polymer polarity: how the cytoskeleton builds a polarized cell
    • Li R., Gundersen G.G. Beyond polymer polarity: how the cytoskeleton builds a polarized cell. Nat. Rev. Mol. Cell Biol. 2008, 9:860-873.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 860-873
    • Li, R.1    Gundersen, G.G.2
  • 24
    • 33745746346 scopus 로고    scopus 로고
    • Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells
    • Liu L.Z., Zhao H.L., Zuo J., Ho S.K., Chan J.C., Meng Y., Fang F.D., Tong P.C. Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells. Mol. Biol. Cell 2006, 17:2322-2330.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2322-2330
    • Liu, L.Z.1    Zhao, H.L.2    Zuo, J.3    Ho, S.K.4    Chan, J.C.5    Meng, Y.6    Fang, F.D.7    Tong, P.C.8
  • 25
    • 77954534432 scopus 로고    scopus 로고
    • The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells
    • Liu L.Z., Cheung S.C., Lan L.L., Ho S.K., Chan J.C., Tong P.C. The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells. Cell. Signal. 2010, 22:1513-1522.
    • (2010) Cell. Signal. , vol.22 , pp. 1513-1522
    • Liu, L.Z.1    Cheung, S.C.2    Lan, L.L.3    Ho, S.K.4    Chan, J.C.5    Tong, P.C.6
  • 26
    • 26844573782 scopus 로고    scopus 로고
    • AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
    • Miinea C.P., Sano H., Kane S., Sano E., Fukuda M., Peranen J., Lane W.S., Lienhard G.E. AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem. J. 2005, 391:87-93.
    • (2005) Biochem. J. , vol.391 , pp. 87-93
    • Miinea, C.P.1    Sano, H.2    Kane, S.3    Sano, E.4    Fukuda, M.5    Peranen, J.6    Lane, W.S.7    Lienhard, G.E.8
  • 27
    • 0035941237 scopus 로고    scopus 로고
    • Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism
    • Molero J.C., Whitehead J.P., Meerloo T., James D.E. Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism. J. Biol. Chem. 2001, 276:43829-43835.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43829-43835
    • Molero, J.C.1    Whitehead, J.P.2    Meerloo, T.3    James, D.E.4
  • 28
    • 40849131138 scopus 로고    scopus 로고
    • Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture
    • Montessuit C., Papageorgiou I., Lerch R. Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture. Endocrinology 2008, 149:1064-1074.
    • (2008) Endocrinology , vol.149 , pp. 1064-1074
    • Montessuit, C.1    Papageorgiou, I.2    Lerch, R.3
  • 29
    • 41449087811 scopus 로고    scopus 로고
    • Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes
    • Ng Y., Ramm G., Lopez J.A., James D.E. Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab. 2008, 7:348-356.
    • (2008) Cell Metab. , vol.7 , pp. 348-356
    • Ng, Y.1    Ramm, G.2    Lopez, J.A.3    James, D.E.4
  • 30
    • 0035070099 scopus 로고    scopus 로고
    • Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
    • Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 2001, 6:107-119.
    • (2001) Genes Cells , vol.6 , pp. 107-119
    • Noda, Y.1    Takeya, R.2    Ohno, S.3    Naito, S.4    Ito, T.5    Sumimoto, H.6
  • 31
    • 0035815634 scopus 로고    scopus 로고
    • Insulin-mediated GLUT4 translocation is dependent on the microtubule network
    • Olson A.L., Trumbly A.R., Gibson G.V. Insulin-mediated GLUT4 translocation is dependent on the microtubule network. J. Biol. Chem. 2001, 276:10706-10714.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10706-10714
    • Olson, A.L.1    Trumbly, A.R.2    Gibson, G.V.3
  • 32
    • 0242552004 scopus 로고    scopus 로고
    • Insulin promotes formation of polymerized microtubules by a phosphatidylinositol 3-kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes
    • Olson A.L., Eyster C.A., Duggins Q.S., Knight J.B. Insulin promotes formation of polymerized microtubules by a phosphatidylinositol 3-kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes. Endocrinology 2003, 144:5030-5039.
    • (2003) Endocrinology , vol.144 , pp. 5030-5039
    • Olson, A.L.1    Eyster, C.A.2    Duggins, Q.S.3    Knight, J.B.4
  • 33
    • 0037706869 scopus 로고    scopus 로고
    • Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells
    • Patel N., Rudich A., Khayat Z.A., Garg R., Klip A. Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells. Mol. Cell. Biol. 2003, 23:4611-4626.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 4611-4626
    • Patel, N.1    Rudich, A.2    Khayat, Z.A.3    Garg, R.4    Klip, A.5
  • 34
    • 0034659420 scopus 로고    scopus 로고
    • A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
    • Qiu R.G., Abo A., Steven Martin G. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr. Biol. 2000, 10:697-707.
    • (2000) Curr. Biol. , vol.10 , pp. 697-707
    • Qiu, R.G.1    Abo, A.2    Steven Martin, G.3
  • 35
    • 34247148430 scopus 로고    scopus 로고
    • Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1
    • Roach W.G., Chavez J.A., Miinea C.P., Lienhard G.E. Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. Biochem. J. 2007, 403:353-358.
    • (2007) Biochem. J. , vol.403 , pp. 353-358
    • Roach, W.G.1    Chavez, J.A.2    Miinea, C.P.3    Lienhard, G.E.4
  • 37
    • 0036470213 scopus 로고    scopus 로고
    • Insulin signaling pathways in time and space
    • Saltiel A.R., Pessin J.E. Insulin signaling pathways in time and space. Trends Cell Biol. 2002, 12:65-71.
    • (2002) Trends Cell Biol. , vol.12 , pp. 65-71
    • Saltiel, A.R.1    Pessin, J.E.2
  • 40
    • 0036252318 scopus 로고    scopus 로고
    • Intracellular insulin-responsive glucose transporter (GLUT4) distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependent
    • Shigematsu S., Khan A.H., Kanzaki M., Pessin J.E. Intracellular insulin-responsive glucose transporter (GLUT4) distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependent. Mol. Endocrinol. 2002, 16:1060-1068.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1060-1068
    • Shigematsu, S.1    Khan, A.H.2    Kanzaki, M.3    Pessin, J.E.4
  • 41
    • 0024324790 scopus 로고
    • Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain
    • Silliman C.C., Sturgill T.W. Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain. Biochem. Biophys. Res. Commun. 1989, 160:993-998.
    • (1989) Biochem. Biophys. Res. Commun. , vol.160 , pp. 993-998
    • Silliman, C.C.1    Sturgill, T.W.2
  • 42
    • 0030810216 scopus 로고    scopus 로고
    • Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
    • Standaert M.L., Galloway L., Karnam P., Bandyopadhyay G., Moscat J., Farese R.V. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J. Biol. Chem. 1997, 272:30075-30082.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30075-30082
    • Standaert, M.L.1    Galloway, L.2    Karnam, P.3    Bandyopadhyay, G.4    Moscat, J.5    Farese, R.V.6
  • 44
    • 0242635511 scopus 로고    scopus 로고
    • DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes
    • Terret M.E., Lefebvre C., Djiane A., Rassinier P., Moreau J., Maro B., Verlhac M.H. DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes. Development 2003, 130:5169-5177.
    • (2003) Development , vol.130 , pp. 5169-5177
    • Terret, M.E.1    Lefebvre, C.2    Djiane, A.3    Rassinier, P.4    Moreau, J.5    Maro, B.6    Verlhac, M.H.7
  • 45
    • 33745365666 scopus 로고    scopus 로고
    • The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity
    • Thomas E.C., Zhe Y., Molero J.C., Schmitz-Peiffer C., Ramm G., James D.E., Whitehead J.P. The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity. Int. J. Biochem. Cell Biol. 2006, 38:1686-1699.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1686-1699
    • Thomas, E.C.1    Zhe, Y.2    Molero, J.C.3    Schmitz-Peiffer, C.4    Ramm, G.5    James, D.E.6    Whitehead, J.P.7
  • 46
    • 33847062845 scopus 로고    scopus 로고
    • The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic
    • Thong F.S., Bilan P.J., Klip A. The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes 2007, 56:414-423.
    • (2007) Diabetes , vol.56 , pp. 414-423
    • Thong, F.S.1    Bilan, P.J.2    Klip, A.3
  • 47
    • 0034907579 scopus 로고    scopus 로고
    • Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles
    • Tong P., Khayat Z.A., Huang C., Patel N., Ueyama A., Klip A. Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles. J. Clin. Invest. 2001, 108:371-381.
    • (2001) J. Clin. Invest. , vol.108 , pp. 371-381
    • Tong, P.1    Khayat, Z.A.2    Huang, C.3    Patel, N.4    Ueyama, A.5    Klip, A.6
  • 48
    • 1242305178 scopus 로고    scopus 로고
    • Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes: microtuble organization, asymmetric division and metaphase II arrest
    • Tong C., Fan H.Y., Chen D.Y., Song X.F., Schatten H., Sun Q.Y. Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes: microtuble organization, asymmetric division and metaphase II arrest. Cell Res. 2003, 13:375-383.
    • (2003) Cell Res. , vol.13 , pp. 375-383
    • Tong, C.1    Fan, H.Y.2    Chen, D.Y.3    Song, X.F.4    Schatten, H.5    Sun, Q.Y.6
  • 49
    • 9444259803 scopus 로고    scopus 로고
    • Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts
    • Torok D., Patel N., Jebailey L., Thong F.S., Randhawa V.K., Klip A., Rudich A. Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts. J. Cell Sci. 2004, 117:5447-5455.
    • (2004) J. Cell Sci. , vol.117 , pp. 5447-5455
    • Torok, D.1    Patel, N.2    Jebailey, L.3    Thong, F.S.4    Randhawa, V.K.5    Klip, A.6    Rudich, A.7
  • 51
    • 0032080114 scopus 로고    scopus 로고
    • Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
    • Wang Q., Bilan P.J., Tsakiridis T., Hinek A., Klip A. Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J. 1998, 331(Pt 3):917-928.
    • (1998) Biochem. J. , vol.331 , Issue.PART 3 , pp. 917-928
    • Wang, Q.1    Bilan, P.J.2    Tsakiridis, T.3    Hinek, A.4    Klip, A.5
  • 52
    • 0032496396 scopus 로고    scopus 로고
    • GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay
    • Wang Q., Khayat Z., Kishi K., Ebina Y., Klip A. GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay. FEBS Lett. 1998, 427:193-197.
    • (1998) FEBS Lett. , vol.427 , pp. 193-197
    • Wang, Q.1    Khayat, Z.2    Kishi, K.3    Ebina, Y.4    Klip, A.5
  • 53
    • 0033049422 scopus 로고    scopus 로고
    • Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
    • Wang Q., Somwar R., Bilan P.J., Liu Z., Jin J., Woodgett J.R., Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol. Cell. Biol. 1999, 19:4008-4018.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4008-4018
    • Wang, Q.1    Somwar, R.2    Bilan, P.J.3    Liu, Z.4    Jin, J.5    Woodgett, J.R.6    Klip, A.7
  • 54
    • 0031918624 scopus 로고    scopus 로고
    • The IRS-signalling system: a network of docking proteins that mediate insulin action
    • White M.F. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 1998, 182:3-11.
    • (1998) Mol. Cell. Biochem. , vol.182 , pp. 3-11
    • White, M.F.1
  • 55
    • 3042743988 scopus 로고    scopus 로고
    • Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
    • Yang L., Dan H.C., Sun M., Liu Q., Sun X.M., Feldman R.I., Hamilton A.D., Polokoff M., Nicosia S.V., Herlyn M., et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res. 2004, 64:4394-4399.
    • (2004) Cancer Res. , vol.64 , pp. 4394-4399
    • Yang, L.1    Dan, H.C.2    Sun, M.3    Liu, Q.4    Sun, X.M.5    Feldman, R.I.6    Hamilton, A.D.7    Polokoff, M.8    Nicosia, S.V.9    Herlyn, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.