Production and characterization of a novel human recombinant alpha-1-antitrypsin in PER.C6 cells

Journal of Biotechnology

Volumn 162, Issue 2-3, 2012, Pages 262-273

  Ross, David ^a   Brown, Tonya ^a   Harper, Richard ^a   Pamarthi, Mohan ^a   Nixon, Jennifer ^a   Bromirski, John ^a   Li, Cheng Ming ^a   Ghali, Reham ^a   Xie, Hongbo ^a   Medvedeff, Gene ^a   Li, Hongbin ^a   Scuderi, Philip ^a   Arora, Vik ^a   Hunt, Jennifer ^a   Barnett, Thomas ^a  

^a Grifols Inc   (United States)

Author keywords

Alpha 1 antitrypsin; PER.C6; Recombinant protein; Sialyltransferase

Indexed keywords

CELL CULTURE; CONTINUOUS CELL CULTURE; DISEASE CONTROL; ENZYME INHIBITION; RECOMBINANT PROTEINS;

ANTITRYPSIN; CONTINUOUS CULTURE; FUNCTIONAL CELLS; HUMAN CELL LINES; PER.C6; PHARMACOKINETIC PROPERTIES; PROTEINASE INHIBITORS; SIALYLTRANSFERASE;

CLONE CELLS;

ALPHA 1 ANTITRYPSIN; GLYCAN; RECOMBINANT ALPHA 1 ANTITRYPSIN; SIALIC ACID; SIALYLTRANSFERASE; UNCLASSIFIED DRUG; N ACETYLNEURAMINIC ACID; RECOMBINANT PROTEIN; SERPINA1 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL CLONING; CONTINUOUS CULTURE; CONTROLLED STUDY; EMBRYONAL CELL LINE; FED BATCH CULTURE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PER.C6 CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIALYLATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; GENETICS; HALF LIFE TIME; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PROTEIN STABILITY;

ALPHA 1-ANTITRYPSIN; ANIMALS; CELL LINE; HALF-LIFE; HUMANS; MALE; MICE; MICE, INBRED ICR; N-ACETYLNEURAMINIC ACID; PROTEIN STABILITY; RECOMBINANT PROTEINS; SIALYLTRANSFERASES;

EID: 84868502136     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.09.018     Document Type: Article

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