Effect of pH on biosynthesis of lovastatin and other secondary metabolites by Aspergillus terreus ATCC 20542

Journal of Biotechnology

Volumn 162, Issue 2-3, 2012, Pages 253-261

  Bizukojc, Marcin ^a   Pawlak, Marta ^a   Boruta, Tomasz ^a   Gonciarz, Joanna ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Aspergillus terreus; Lactonisation; Lovastatin; Mass spectrometry; Mevinolinic acid; pH

Indexed keywords

ASPERGILLUS; BIOCHEMISTRY; BIOSYNTHESIS; EQUILIBRIUM CONSTANTS; MASS SPECTROMETRY; METABOLITES; PH;

ASPERGILLUS TERREUS; ASPERGILLUS TERREUS ATCC 20542; EQUILIBRIUM CURVES; INITIAL PH VALUE; LACTONISATION; LOVASTATIN; MEVINOLINIC ACID; SECONDARY METABOLITES;

PH EFFECTS;

BETA HYDROXYACID; GEODIN; HYDROXYACID; LACTOSE; MEVINOLIN; MEVINOLINIC ACID; MONACOLIN L; POLYKETIDE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; LACTONE;

ANALYTIC METHOD; ARTICLE; ASPERGILLUS TERREUS; BROTH DILUTION; DRUG SYNTHESIS; EQUILIBRIUM CONSTANT; FUNGAL STRAIN; FUNGUS CULTURE; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NONHUMAN; PH; PRIORITY JOURNAL; ASPERGILLUS; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; MASS SPECTROMETRY; METABOLISM; NONLINEAR SYSTEM;

ASPERGILLUS; CULTURE MEDIA; HYDROGEN-ION CONCENTRATION; LACTONES; LACTOSE; LOVASTATIN; MASS SPECTROMETRY; NONLINEAR DYNAMICS;

EID: 84868499370     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.09.007     Document Type: Article

References (27)

1. Bizukojc, M., Ledakowicz, S., Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus Aspergillus terreus. Journal of Biotechnology 132 (2007), 453–460.
2. Bizukojc, M., Ledakowicz, S., Biosynthesis of lovastatin and (+)-geodin by Aspergillus terreus in batch and fed-batch culture in the stirred tank bioreactor. Biochemical Engineering Journal 42 (2008), 198–207.
3. Bizukojc, M., Pecyna, M., Lovastatin and (+)-geodin formation by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources. Engineering in Life Sciences 11 (2011), 272–282.
4. Casas Lopez, J.L., Sanchez Perez, J.A., Fernandez Sevilla, J.M., Acien Fernandez, F.G., Molina Grima, E., Chisti, Y., Production of lovastatin by Aspergillus terreus: effects of the C N ratio and the principal nutrients on growth and metabolite production. Enzyme and Microbial Technology 33 (2003), 270–277.
5. Casas Lopez, J.L., Sanchez Perez, J.A., Fernandez Sevilla, J.M., Rodriguez Porcel, E.M., Chisti, Y., Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus. Journal of Biotechnology 116 (2005), 61–77.
6. Friedrich, J., Zuzek, M., Bencina, M., Cimerman, A., Strancar, A., Radez, I., High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. Journal of Chromatography A 704 (1995), 363–367.
7. Hajjaj, H., Niederberger, P., Duboc, P., Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Applied and Environmental Microbiology 67 (2001), 2596–2602.
8. Jia, Z., Zhang, X., Zhao, Y., Cao, X., Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically defined medium. World Journal of Microbiology and Biotechnology 25 (2009), 1235–1241.
9. Kumar, M.S., Jana, S.K., Senthil, V., Shashanka, V., Kumar, S.V., Sadhukhan, A.K., Repeated fed-batch process for improving lovastatin production. Process Biochemistry 36 (2000), 363–368.
10. Lai, L.-S.T., Hung, C.S., Lo, C.C., Effects of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC20542. Journal of Bioscience and Bioengineering 104 (2007), 9–13.
11. Lai, L.-S.T., Pan, C.C., Tzeng, B.K., The influence of medium design on lovastatin production and pellet formation with a high producing mutant of Aspergillus terreus in submerged cultures. Process Biochemistry 38 (2003), 1317–1326.
12. Lai, L.-S.T., Tsai, T.-H., Wang, T.C., Application of oxygen vectors to Aspergillus terreus cultivation. Journal of Bioscience and Bioengineering 94 (2002), 453–459.
13. Lai, L.-S.T., Tsai, T.-H., Wang, T.C., Cheng, T.Y., The influence of culturing environments on lovastatin production by Aspergillus terreus in submerged cultures. Enzyme and Microbial Technology 36 (2005), 737–748.
14. Liu, G., Xu, Z., Cen, P., A morphologically structured model for mycelial growth and secondary metabolite formation. Chinese Journal of Chemical Engineering 8 (2000), 46–51.
15. Manzoni, M., Rollini, M., Bergomi, S., Cavazzoni, V., Production and purification of statins from Aspergillus terreus strains. Biotechnology Techniques 12 (1998), 529–532.
16. Morrison, R.T., Boyd, R.N., Organic Chemistry. sixth ed., 1992, Prentice Hall Inc., Englewood Cliffs, New Jersey.
17. Novak, N., Gerdin, S., Berovic, M., Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process. Biotechnology Letters 19 (1997), 947–948.
18. Osman, M.E., Khattab, O.H., Zaghlol, G.M., Abd El-Hameed, R.M., Optimization of some physical and chemical factors for lovastatin productivity by local strain of Aspergillus terreus. Australian Journal of Basic and Applied Sciences 5:6 (2011), 718–732.
19. Paul, G.C., Thomas, C.R., A structured model for hyphal differentiation and penicillin production using Penicillium chrysogenum. Biotechnology and Bioengineering 51 (1996), 558–572.
20. Pawlak, M., Bizukojc, M., Intensification of lovastatin biosynthesis with the use of lactose and glycerol as carbon sources in a batch and in discontinuous fed-batch and continuous fed-batch culture. (in Polish). Chemical Engineering and Equipment (Inzynieria i Aparatura Chemiczna) 51:4 (2012), 164–166.
21. Pawlak, M., Bizukojc, M., Ledakowicz, S., Impact of bioreactor scale on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture. Chemical and Process Engineering 33:1 (2012), 71–84.
22. Rodriguez Porcel, E.M., Casas Lopez, J.L., Sanchez Perez, J.A., Chisti, Y., Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy. Journal of Chemical Technology and Biotechnology 82 (2007), 58–64.
23. Rodriguez Porcel, E.M., Casas Lopez, J.L., Sanchez Perez, J.A., Chisti, Y., Lovastatin production in a two-staged feeding operation. Journal of Chemical Technology and Biotechnology 83 (2008), 1236–1243.
24. Rollini, M., Manzoni, M., Influence of medium design on lovastatin and mevastatin production by Aspergillus terreus strains. Annals of Microbiology 56:1 (2006), 47–51.
25. Sun, H., Gong, J.-B., Wang, J.K., Solubility of lovastatin in acetone, methanol, ethanol, ethyl acetate, and butyl acetate between 283 K and 323 K. Journal of Chemical and Engineering Data 50:4 (2005), 1389–1391.
26. Treiber, L.R., Reamer, R.A., Rooney, C.S., Ramjit, H.G., Origin of monacolin L from Aspergillus terreus cultures. Journal of Antibiotics 42:1 (1989), 30–36.
27. Wang, H., Wu, Y., Zhao, Z., Fragmentation study of simvastatin and lovastatin using electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry 36 (2001), 58–70.