Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo

Toxicology and Applied Pharmacology

Volumn 265, Issue 2, 2012, Pages 190-199

  Li, Juan ^a   Dai, Cai Xia ^a   Sun, Hua ^a   Jin, Lu ^a,b   Guo, Chong Yi ^a   Cao, Wei ^a   Wu, Jie ^a   Tian, Hai Yan ^a   Luo, Cheng ^b   Ye, Wen Cai ^a   Jiang, Ren Wang ^a  

^a JINAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Curcumin; Oxidative stress; Podophyllotoxin; Toxicity; Tubulin

Indexed keywords

ALKALINE PHOSPHATASE; COLCHICINE; CREATININE; CURCUMIN; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PODOPHYLLOTOXIN; SUPEROXIDE DISMUTASE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; G2 PHASE CELL CYCLE CHECKPOINT; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; LIVER FUNCTION; LIVER TOXICITY; M PHASE CELL CYCLE CHECKPOINT; MALE; MEMBRANE POTENTIAL; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; UREA BLOOD LEVEL; VERO CELL;

ANIMALS; CELL CYCLE; CERCOPITHECUS AETHIOPS; CURCUMIN; DRUG INTERACTIONS; FLOW CYTOMETRY; HISTOCYTOCHEMISTRY; KIDNEY; LIVER; MALE; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; OXIDATIVE STRESS; PODOPHYLLOTOXIN; SPECIFIC PATHOGEN-FREE ORGANISMS; TUBULIN; VERO CELLS;

MUS;

EID: 84868444549     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.10.010     Document Type: Article

References (48)

1. Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv. Exp. Med. Biol. 2007, 595:1-75.
2. Bar-Sela G., Epelbaum R., Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr. Med. Chem. 2010, 17:190-197.
3. Barzegar A., Moosavi-Movahedi A.A. Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PLoS One 2011, 6:e26012.
4. Bernstein F.C., Koetzle T.F., Williams G.J., Meyer E.F., Brice M.D., Rodgers J.R., Kennard O., Shimanouchi T., Tasumi M. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 1977, 112:535-542.
5. Boyd J.W. The mechanisms relating to increase in plasma enzymes and isoenzymes in disease of animals. Vet. Clin. Pathol. 1985, 12:9-24.
6. Chakraborty S., Roy M., Bhattacharya R.K. Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. J. Environ. Pathol. Toxicol. Oncol. 2004, 23:215-226.
7. Chen Y.T. A fatal fibrillation atrial and coagulopathy by Dysosma versipallis rhizome poisoning. Chin. J. Prim. Med. Pharm. 2004, 11:1330.
8. Cortese F., Bhattacharyya B., Wolf J. Podophyllotoxin as a probe for the colchicine binding site of tubulin. J. Biol. Chem. 1977, 252:1134-1140.
9. Couchoud C., Pozet N., Labeeuw M., Pouteil-Noble C. Screening early renal failure: cut-off values for serum creatinine as an indicator of renal impairment. Kidney Int. 1999, 55:1878-1884.
10. Desbene S., Giorgi-Renault S. Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues. Curr. Med. Chem. Anticancer Agents 2002, 2:71-90.
11. Dobb G.F., Edis R.H. Coma and neuropathy after ingestion of herbal laxative containing podophyllin. Med. J. Aust. 1984, 140:495-496.
12. Eybl V., Kotyzova D., Koutensky J. Comparative study of natural antioxidants-curcumin, resveratrol and melatonin-in cadmium-induced oxidative damage in mice. Toxicology 2006, 225:150-156.
13. Fang J., Hong S. A case of multiple organs function failure by Dysosma versipallis rhizome poisoning. Chin. Community Doctors 2003, 19:46.
14. Feng N., Cai S. A fatal Dysosma versipallis rhizome poisoning. Clin. Focus 2003, 18:226-227.
15. Friesner R.A., Banks J.L., Murphy R.B., Halgren T.A., Klicic J.J., Mainz D.T., Repasky M.P., Knoll E.H., Shelley M., Perry J.K., Shaw D.E., Francis P., Shenkin P.S. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J. Med. Chem. 2004, 47:1739-1749.
16. Fu Y., Zheng S., Lin J., Ryerse J., Chen A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol. Pharmacol. 2008, 73:399-409.
17. Gong X., Zhang Q.M., Li Y.C. Clinical and electrophysiologic analysis of 17 cases of Dysosma versipallis rhizome poisoning. J. Apoplexy Nerv. Dis. 2006, 27:14.
18. Gupta K., Bishop J., Peck A., Brown J., Wilson L., Panda D. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochemistry 2004, 43:6645-6655.
19. Gupta K.K., Bharne S.S., Rathinasamy K., Naik N.R., Panda D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J. 2006, 273:5320-5332.
20. Jackson D.E., Dewick P.M. Tumor-inhibitory aryltetralin lignans from Podophyllum pleianthum. Phytochemistry 1985, 24:2407-2409.
21. Jin Z., Yuan J. A toxic encephacopathy by misuse of Dysosma versipallis rhizome medicinal wine. Chin. J. Chin. Mater. Med. 2003, 28:477.
22. Kao W.F., Hung D.Z., Tsai W.J., Lin K.P., Deng J.F. Podophyllotoxin intoxication: toxic effect of Bajiaolian in herbal therapeutics. Hum. Exp. Toxicol. 1992, 11:480-487.
23. Li X., Jiang G. A central lesion case by Dysosma versipallis rhizome poisoning. Chin. Acup. Moxibustion 2007, 27:114.
24. Lin T., Yang M.S. Benzo[a]pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells. Toxicology 2007, 235:1-10.
25. Liu Y.Q., Yang L., Tian X. Podophyllotoxin: current perspectives. Curr. Bioact. Compd. 2007, 3:37-66.
26. Liu W., Fan Z., Han Y., Lu S., Zhang D., Bai X., Xu W., Li J., Wang H. Curcumin attenuates peroxynitrite-induced neurotoxicity in spiral ganglion neurons. Neurotoxicology 2011, 32:150-157.
27. Ma C., Yang J.S., Luo S.R. Lignans from Diphylleia sinensis. Yao Xue Xue Bao 1993, 28:690-694.
28. Manso-Martinez R. Podophyliotoxin poisoning of microtubules at steady-state: effect of substoichiometric and superstoichiometric concentrations of drug. Mol. Cell. Biochem. 1982, 45:3-11.
29. Marczylo T.H., Steward W.P., Gescher A.J. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J. Agric. Food Chem. 2009, 57:797-803.
30. McLean A.E. Hepatic failure in malnutrition. Lancet 1962, 2:1229-1295.
31. Memis D., Hekimoglu S., Sezer A., Altaner S., Sut N., Usta U. Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. Nutrition 2008, 24:1133-1138.
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
33. Naik S.R., Thakare V.N., Patil S.R. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Exp. Toxicol. Pathol. 2011, 63:419-431.
34. Pan M.H., Huang T.M., Lin J.K. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos. 1999, 27:486-494.
35. Perkins S., Verschoyle R.D., Hill K., Parveen I., Threadgill M.D., Sharma R.A., Williams M.L., Steward W.P., Gescher A.J. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol. Biomarkers Prev. 2002, 11:535-540.
36. Rosser B.G., Gores G.J. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 1995, 108:252-275.
37. Rukkumani R., Aruna K., Varma P.S., Rajasekaran K.N., Menon V.P. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J. Pharm. Pharm. Sci. 2004, 7:274-283.
38. San F.A., Gordaliza M., Miguel del Corral J.M., Castro M.A., Garcia-Gravalos M.D., Ruiz-Lazaro P. Antineoplastic and antiviral activities of some cyclolignans. Planta Med. 1993, 59:246-249.
39. Seo S.W., Han H.K., Chun M.K., Choi H.K. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. Int. J. Pharm. 2012, 424:18-25.
40. Shi Y., Wei X., Yao Q. Chemical constituents of Dysosma pleiantha. Zhongcaoyao 2005, 36:484-486.
41. Suresh D., Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J. Med. Res. 2010, 131:682-691.
42. Tirkey N., Kaur G., Vij G., Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005, 5:15-25.
43. Venkatesan N. Pulmonary protective effects of curcumin against paraquat toxicity. Life Sci. 2000, 66:21-28.
44. Vitaglione P., Barone L.R., Ferracane R., Radetsky I., Mennella I., Schettino R., Koder S., Shimoni E., Fogliano V. Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients. J. Agric. Food Chem. 2012, 60:3357-3366.
45. Wallace A.C., Laskowski R.A., Thornton J.M. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng. 1995, 8:127-134.
46. Wongcharoen W., Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int. J. Cardiol. 2009, 133:145-151.
47. Xia L.Y. Modern Chinese Drugs Toxicology. Tianjin Sci-Tech 2005, 556-557. Tanslation Publishers.
48. Yousef M.I., Omar S.A.M., El-Guendi M.I., Abdelmegid L.A. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem. Toxicol. 2010, 48:3246-3261.