메뉴 건너뛰기




Volumn 37, Issue 6, 2012, Pages 704-711

Lack of clinically significant pharmacological interactions between ticagrelor and enoxaparin or unfractionated heparin in healthy subjects

Author keywords

drug drug interaction; enoxaparin; pharmacodynamic; pharmacokinetic; ticagrelor; unfractionated heparin

Indexed keywords

ANTIBODY; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A ANTIBODY; ENOXAPARIN; HEPARIN; TICAGRELOR; UNCLASSIFIED DRUG;

EID: 84868366539     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2012.01367.x     Document Type: Article
Times cited : (4)

References (44)
  • 1
    • 4544327298 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of patients with acute myocardial infarction)
    • Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of patients with acute myocardial infarction). J Am Coll Cardiol, 2004; 44: E1-E211.
    • (2004) J Am Coll Cardiol , vol.44
    • Antman, E.M.1    Anbe, D.T.2    Armstrong, P.W.3
  • 2
    • 34548545280 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • (Writing Committee to Revise the 2002 Guidelines for the Management of Patients with Unstable Angina/Non ST-Elevation Myocardial Infarction): Developed in collaboration with the American College of Emergency Physicians the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
    • Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation, 2007; 116: e148-e304.
    • (2007) Circulation , vol.116
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 3
    • 57349189353 scopus 로고    scopus 로고
    • Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology
    • Van de Werf F, Bax J, Betriu A, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J, 2008; 29: 2909-2945.
    • (2008) Eur Heart J , vol.29 , pp. 2909-2945
    • Van De Werf, F.1    Bax, J.2    Betriu, A.3
  • 4
    • 34547772153 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
    • Bassand JP, Hamm CW, Ardissino D, et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J, 2007; 28: 1598-1660.
    • (2007) Eur Heart J , vol.28 , pp. 1598-1660
    • Bassand, J.P.1    Hamm, C.W.2    Ardissino, D.3
  • 5
    • 18044388905 scopus 로고    scopus 로고
    • Preclinical and clinical studies with selective reversible direct P2Y12 antagonists
    • van Giezen JJ, Humphries RG,. Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Semin Thromb Hemost, 2005; 31: 195-204.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • Van Giezen, J.J.1    Humphries, R.G.2
  • 6
    • 77954468084 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects
    • Teng R, Butler K,. Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects. Eur J Clin Pharmacol, 2010; 66: 487-496.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 487-496
    • Teng, R.1    Butler, K.2
  • 7
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G,. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J, 2006; 27: 1038-1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 8
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • Gurbel PA, Bliden KP, Butler K, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation, 2009; 120: 2577-2585.
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 9
    • 69249213604 scopus 로고    scopus 로고
    • Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation
    • van Giezen JJ, Nilsson L, Berntsson P, et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation. J Thromb Haemost, 2009; 7: 1556-1565.
    • (2009) J Thromb Haemost , vol.7 , pp. 1556-1565
    • Van Giezen, J.J.1    Nilsson, L.2    Berntsson, P.3
  • 10
    • 67649356342 scopus 로고    scopus 로고
    • Direct oral P2Y12 receptor antagonist AZD6140 potently and reversibly binds to the rh-P2Y12 receptor expressed on CHO-K1 cells
    • (abst P207)
    • van Giezen JJJ, Berntsson P, Wissing BM,. Direct oral P2Y12 receptor antagonist AZD6140 potently and reversibly binds to the rh-P2Y12 receptor expressed on CHO-K1 cells. Arterioscler Thromb Vasc Biol, 2008; 28: e-72 (abst P207).
    • (2008) Arterioscler Thromb Vasc Biol , vol.28
    • Van Giezen, J.J.J.1    Berntsson, P.2    Wissing, B.M.3
  • 11
    • 77955992168 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects
    • Teng R, Oliver S, Hayes MA, Butler K,. Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects. Drug Metab Dispos, 2010; 38: 1514-1521.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1514-1521
    • Teng, R.1    Oliver, S.2    Hayes, M.A.3    Butler, K.4
  • 12
    • 77953498801 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers
    • Butler K, Teng R,. Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers. Br J Clin Pharmacol, 2010; 70: 65-77.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 65-77
    • Butler, K.1    Teng, R.2
  • 13
    • 35548995394 scopus 로고    scopus 로고
    • Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: Primary results of the DISPERSE-2 trial
    • Cannon CP, Husted S, Harrington RA, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 trial. J Am Coll Cardiol, 2007; 50: 1844-1851.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1844-1851
    • Cannon, C.P.1    Husted, S.2    Harrington, R.A.3
  • 14
    • 35548933800 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    • Storey RF, Husted S, Harrington RA, et al. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol, 2007; 50: 1852-1856.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1852-1856
    • Storey, R.F.1    Husted, S.2    Harrington, R.A.3
  • 15
    • 77958003916 scopus 로고    scopus 로고
    • Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: The PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy
    • Storey RF, Angiolillo DJ, Patil SB, et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy. J Am Coll Cardiol, 2010; 56: 1456-1462.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1456-1462
    • Storey, R.F.1    Angiolillo, D.J.2    Patil, S.B.3
  • 16
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med, 2009; 361: 1045-1057.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 17
    • 77953201509 scopus 로고    scopus 로고
    • Anticoagulant therapy for percutaneous coronary intervention
    • Rao SV, Ohman EM,. Anticoagulant therapy for percutaneous coronary intervention. Circ Cardiovasc Interv, 2010; 3: 80-88.
    • (2010) Circ Cardiovasc Interv , vol.3 , pp. 80-88
    • Rao, S.V.1    Ohman, E.M.2
  • 19
    • 0015819385 scopus 로고
    • The potentiation of platelet aggregation and adhesion by heparin in vitro and in vivo
    • Thomson C, Forbes CD, Prentice CR,. The potentiation of platelet aggregation and adhesion by heparin in vitro and in vivo. Clin Sci Mol Med, 1973; 45: 485-494.
    • (1973) Clin Sci Mol Med , vol.45 , pp. 485-494
    • Thomson, C.1    Forbes, C.D.2    Prentice, C.R.3
  • 20
    • 0015278353 scopus 로고
    • The platelet aggregating effect of eight commercial heparins
    • Eika C,. The platelet aggregating effect of eight commercial heparins. Scand J Haematol, 1972; 9: 480-482.
    • (1972) Scand J Haematol , vol.9 , pp. 480-482
    • Eika, C.1
  • 21
    • 0036624483 scopus 로고    scopus 로고
    • Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: Implications for coronary intervention
    • Aggarwal A, Sobel BE, Schneider DJ,. Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary intervention. J Thromb Thrombolysis, 2002; 13: 161-165.
    • (2002) J Thromb Thrombolysis , vol.13 , pp. 161-165
    • Aggarwal, A.1    Sobel, B.E.2    Schneider, D.J.3
  • 22
    • 0030664732 scopus 로고    scopus 로고
    • Differential effects of anticoagulants on the activation of platelets ex vivo
    • Schneider DJ, Tracy PB, Mann KG, Sobel BE,. Differential effects of anticoagulants on the activation of platelets ex vivo. Circulation, 1997; 96: 2877-2883.
    • (1997) Circulation , vol.96 , pp. 2877-2883
    • Schneider, D.J.1    Tracy, P.B.2    Mann, K.G.3    Sobel, B.E.4
  • 23
    • 77955846807 scopus 로고    scopus 로고
    • Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometry
    • Sillen H, Cook M, Davis P,. Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2010; 878: 2299-2306.
    • (2010) J Chromatogr B Analyt Technol Biomed Life Sci , vol.878 , pp. 2299-2306
    • Sillen, H.1    Cook, M.2    Davis, P.3
  • 25
    • 84855931347 scopus 로고    scopus 로고
    • Evaluation and characterization of the ticagrelor effects on serum and urinary uric acid in healthy volunteers
    • Butler K, Teng R,. Evaluation and characterization of the ticagrelor effects on serum and urinary uric acid in healthy volunteers. Clin Pharmacol Ther, 2012; 91: 264-271.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 264-271
    • Butler, K.1    Teng, R.2
  • 26
    • 79955964309 scopus 로고    scopus 로고
    • Heparin promotes platelet responsiveness by potentiating alphaIIbbeta3-mediated outside-in signaling
    • Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ,. Heparin promotes platelet responsiveness by potentiating alphaIIbbeta3-mediated outside-in signaling. Blood, 2011; 117: 4946-4952.
    • (2011) Blood , vol.117 , pp. 4946-4952
    • Gao, C.1    Boylan, B.2    Fang, J.3    Wilcox, D.A.4    Newman, D.K.5    Newman, P.J.6
  • 27
    • 0345487533 scopus 로고    scopus 로고
    • Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor
    • Xiao Z, Theroux P,. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Circulation, 1998; 97: 251-256.
    • (1998) Circulation , vol.97 , pp. 251-256
    • Xiao, Z.1    Theroux, P.2
  • 28
    • 33646580358 scopus 로고    scopus 로고
    • Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively
    • Pleym H, Videm V, Wahba A, et al. Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively. Eur J Cardiothorac Surg, 2006; 29: 933-940.
    • (2006) Eur J Cardiothorac Surg , vol.29 , pp. 933-940
    • Pleym, H.1    Videm, V.2    Wahba, A.3
  • 29
    • 0022899526 scopus 로고
    • Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro
    • Westwick J, Scully MF, Poll C, Kakkar VV,. Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. Thromb Res, 1986; 42: 435-447.
    • (1986) Thromb Res , vol.42 , pp. 435-447
    • Westwick, J.1    Scully, M.F.2    Poll, C.3    Kakkar, V.V.4
  • 30
    • 0031007008 scopus 로고    scopus 로고
    • The platelet proaggregating and potentiating effects of unfractionated heparin, low molecular weight heparin and heparinoid in intensive care patients and healthy controls
    • Burgess JK, Chong BH,. The platelet proaggregating and potentiating effects of unfractionated heparin, low molecular weight heparin and heparinoid in intensive care patients and healthy controls. Eur J Haematol, 1997; 58: 279-285.
    • (1997) Eur J Haematol , vol.58 , pp. 279-285
    • Burgess, J.K.1    Chong, B.H.2
  • 31
    • 2942700120 scopus 로고    scopus 로고
    • Attenuation of platelet reactivity by enoxaparin compared with unfractionated heparin in patients undergoing haemodialysis
    • Aggarwal A, Whitaker DA, Rimmer JM, et al. Attenuation of platelet reactivity by enoxaparin compared with unfractionated heparin in patients undergoing haemodialysis. Nephrol Dial Transplant, 2004; 19: 1559-1563.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 1559-1563
    • Aggarwal, A.1    Whitaker, D.A.2    Rimmer, J.M.3
  • 32
    • 0038506232 scopus 로고    scopus 로고
    • A whole blood flow cytometric determination of platelet activation by unfractionated and low molecular weight heparin in vitro
    • Klein B, Faridi A, von Tempelhoff GF, Heilmann L, Mittermayer C, Rath W,. A whole blood flow cytometric determination of platelet activation by unfractionated and low molecular weight heparin in vitro. Thromb Res, 2002; 108: 291-296.
    • (2002) Thromb Res , vol.108 , pp. 291-296
    • Klein, B.1    Faridi, A.2    Von Tempelhoff, G.F.3    Heilmann, L.4    Mittermayer, C.5    Rath, W.6
  • 33
    • 0032807806 scopus 로고    scopus 로고
    • Prolonged heparin administration during clopidogrel treatment in healthy subjects
    • Caplain H, D'Honneur G, Cariou R,. Prolonged heparin administration during clopidogrel treatment in healthy subjects. Semin Thromb Hemost, 1999; 25 (Suppl 2): 61-64.
    • (1999) Semin Thromb Hemost , vol.25 , Issue.SUPPL. 2 , pp. 61-64
    • Caplain, H.1    D'Honneur, G.2    Cariou, R.3
  • 35
    • 0038291841 scopus 로고    scopus 로고
    • Clopidogrel and warfarin: Absence of interaction in patients receiving long-term anticoagulant therapy for non-valvular atrial fibrillation
    • Lidell C, Svedberg LE, Lindell P, Bandh S, Job B, Wallentin L,. Clopidogrel and warfarin: absence of interaction in patients receiving long-term anticoagulant therapy for non-valvular atrial fibrillation. Thromb Haemost, 2003; 89: 842-846.
    • (2003) Thromb Haemost , vol.89 , pp. 842-846
    • Lidell, C.1    Svedberg, L.E.2    Lindell, P.3    Bandh, S.4    Job, B.5    Wallentin, L.6
  • 36
    • 77952400164 scopus 로고    scopus 로고
    • Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel
    • Sibbing D, von Beckerath N, Morath T, et al. Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel. Eur Heart J, 2010; 31: 1205-1211.
    • (2010) Eur Heart J , vol.31 , pp. 1205-1211
    • Sibbing, D.1    Von Beckerath, N.2    Morath, T.3
  • 37
    • 0033678468 scopus 로고    scopus 로고
    • Identification and biological activity of the active metabolite of clopidogrel
    • Savi P, Pereillo JM, Uzabiaga MF, et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost, 2000; 84: 891-896.
    • (2000) Thromb Haemost , vol.84 , pp. 891-896
    • Savi, P.1    Pereillo, J.M.2    Uzabiaga, M.F.3
  • 38
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt JT, Close SL, Iturria SJ, et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost, 2007; 5: 2429-2436.
    • (2007) J Thromb Haemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3
  • 39
    • 57349097594 scopus 로고    scopus 로고
    • Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon
    • Beinema M, Brouwers JR, Schalekamp T, Wilffert B,. Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb Haemost, 2008; 100: 1052-1057.
    • (2008) Thromb Haemost , vol.100 , pp. 1052-1057
    • Beinema, M.1    Brouwers, J.R.2    Schalekamp, T.3    Wilffert, B.4
  • 40
    • 2942562619 scopus 로고    scopus 로고
    • Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro
    • Ufer M, Svensson JO, Krausz KW, Gelboin HV, Rane A, Tybring G,. Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro. Eur J Clin Pharmacol, 2004; 60: 173-182.
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 173-182
    • Ufer, M.1    Svensson, J.O.2    Krausz, K.W.3    Gelboin, H.V.4    Rane, A.5    Tybring, G.6
  • 41
    • 46449103184 scopus 로고    scopus 로고
    • The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
    • Williams ET, Jones KO, Ponsler GD, et al. The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2. Drug Metab Dispos, 2008; 36: 1227-1232.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1227-1232
    • Williams, E.T.1    Jones, K.O.2    Ponsler, G.D.3
  • 42
    • 34247256797 scopus 로고    scopus 로고
    • Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently
    • Farid NA, Payne CD, Small DS, et al. Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther, 2007; 81: 735-741.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 735-741
    • Farid, N.A.1    Payne, C.D.2    Small, D.S.3
  • 43
    • 78349232464 scopus 로고    scopus 로고
    • Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel
    • Small DS, Farid NA, Payne CD, et al. Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel. Clin Pharmacokinet, 2010; 49: 777-798.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 777-798
    • Small, D.S.1    Farid, N.A.2    Payne, C.D.3
  • 44
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid NA, Kurihara A, Wrighton SA,. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol, 2010; 50: 126-142.
    • (2010) J Clin Pharmacol , vol.50 , pp. 126-142
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.