Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively

European Journal of Cardio-thoracic Surgery

Volumn 29, Issue 6, 2006, Pages 933-940

  Pleym, Hilde ^a   Videm, Vibeke ^a,b   Wahba, Alexander ^a,b   Åsberg, Arne ^a   Amundsen, Tore ^a   Bjella, Lise ^a   Dale, Ola ^b   Stenseth, Roar ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Anticoagulants; Coagulation; Coronary surgery; Hemorrhage; Heparin; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; ANTIPLASMIN; ANTITHROMBIN; D DIMER; ENOXAPARIN; FIBRINOGEN; INTERLEUKIN 8; LOW MOLECULAR WEIGHT HEPARIN; PLASMIN; PROTEIN C; PROTEIN S; PROTHROMBIN; THROMBIN ANTITHROMBIN COMPLEX; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; CORONARY ARTERY SURGERY; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HEART MUSCLE ISCHEMIA; HEMOSTASIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PERIOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RESPIRATORY FAILURE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT;

AGED; ANTICOAGULANTS; BLOOD COAGULATION; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; ENOXAPARIN; FEMALE; HEMOSTASIS, SURGICAL; HEPARIN; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET COUNT; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES;

EID: 33646580358     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2006.02.007     Document Type: Article

References (25)

1. Merlini P.A., Bauer K.A., Oltrona L., Arddissino D., Cattaneo M., Belli C., Mannucci P.M., and Rosenberg R.D. Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 90 (1994) 61-68
2. Hoffmeister H.M., Jur M., Wendel H.P., Heller W., and Seipel L. Alterations of coagulation and fibrinloytic and kallikrein-kinin systems in acute and postacute phases in patients with unstable angina. Circulation 91 (1995) 2520-2527
3. The RISC Group. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 336 (1990) 827-830
4. Fragmin during instability in coronary artery disease (FRISC) study group. Low molecular-weight heparin during instability in coronary artery disease. Lancet 347 (1996) 561-568
5. The efficacy and safety of subcutaneous enoxaparin in non-Q-wave coronary events study group. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med 337 (1997) 447-452
6. Antman E.M., McCabe C.H., Gurfinkel E.P., Turpie A.G.G., Bernink J.L.M., Salein D., Bayes de Luna A., Fox K., Lablanche J.M., Radley D., Premmereur J., Braunwald E., and for the TIMI 11B investigators. Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial. Circulation 100 (1999) 1593-1601
7. Bjessmo S., Ivert T., and Egberg N. Coagulation system activity before coronary artery bypass surgery for unstable angina. Scand Cardiovasc J 35 (2001) 280-284
8. Boisclair M.D., Lane D.A., Philippou H., Esnouf M.P., Sheikh S., Hunt B., and Smith K.J. Mechanisms of thrombin generation during surgery and cardiopulmonary bypass. Blood 82 (1993) 3350-3357
9. Boisclair M.D., Lane D.A., Philippou H., Sheikh S., and Hunt B. Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2. Thromb Haemost 70 (1993) 253-258
10. Hunt B.J., Parratt R.N., Segal H.C., Sheikh S., Kallis P., and Yacoub M. Activation of coagulation and fibrinolysis during cardiothoracic operations. Ann Thorac Surg 65 (1998) 712-718
11. Slaughter T.F., LeBleu T.H., Douglas J.M., Leslie J.B., Parker J.K., and Greenberg C.S. Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers. Anesthesiology 80 (1994) 520-526
12. Tanaka K., Takao M., Yada I., Yuasa H., Kusagawa M., and Deguchi K. Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery. J Cardiothorac Anesth 3 (1989) 181-188
13. Ranucci M., Isgro G., Cazzangia A., Ditta A., Boncilli A., Cotza M., Carboni G., and Brozzi S. Different patterns of heparin resistance: therapeutic implications. Perfusion 17 (2002) 199-204
14. Despotis G.J., Levine V., Joist J.H., Joiner-Maier D., and Spitznagel E. Antithrombin III during cardiac surgery: effect on response of activated clotting time to heparin and relationship to markers of hemostatic activation. Anesth Analg 85 (1997) 498-506
15. Lemmer J.H., and Despotis G.J. Antithrombin III concentrate to treat heparin resistance in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 123 (2002) 213-217
16. Wahba A., and Videm V. Heart surgery with extracorporeal circulation leads to platelet activation at the time of hospital discharge. Eur J Cardiothorac Surg 23 (2003) 1046-1050
17. Pleym H., Wahba A., Videm V., Åsberg A., Lydersen S., Bjella L., Dale O., and Stenseth R. Increased fibrinolysis and platelet activation in elderly patients undergoing coronary bypass surgery. Anesth Analg 102 (2006) 660-667
18. Becker R.C., Tracy R.P., Bovill E.G., Mann K.G., Ault K., and for the TIMI-III thrombosis and anticoagulation study group. The clinical use of flow cytometry for assessing platelet activation in acute coronary syndromes. Coron Artery Dis 4 (1994) 339-345
19. Parker III C., Vita J.A., and Freedman J.E. Soluble adhesion molecules and unstable coronary artery disease. Atherosclerosis 156 (2001) 417-424
20. Furman M.I., Benoit S.E., Barnard M.R., Valeri C.R., Borbone M.L., Becker R.C., Hechtman H.B., and Michelson A.D. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol 31 (1998) 352-358
21. Wahba A., Black G., Koksch M., Rothe G., Preuner J., Schmitz G., and Birnbaum D.E. Cardiopulmonary bypass leads to a preferential loss of activated platelets. Eur J Cardiothorac Surg 10 (1996) 768-773
22. Wahba A., Rothe G., Lodes H., Barlage S., Scmitz G., and Birnbaum D.E. Effects of extracorporeal circulation and heparin on the phenotype of platelet surface antigens following heart surgery. Thromb Res 97 (2000) 379-386
23. Khuri S.F., Valeri C.R., Loscaloz J., Weinstein M.J., Birjiniuk V., Healey N.A., MacGregor H., Doursounian M., and Zolkewitz M.A. Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass. Ann Thorac Surg 60 (1995) 1008-1014
24. Pleym H., Stenseth R., Wahba A., Bjella L., Karevold A., and Dale O. Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesth Analg 96 (2003) 923-928
25. Medalion B., Frenkel G., Patachenko P., Hauptman E., Sasson L., and Schachner A. Preoperative use of enoxaparin is not a risk factor for postoperative bleeding after coronary artery bypass surgery. J Thorac Cardiovasc Surg 126 (2003) 1875-1879