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Volumn 38, Issue 4, 2012, Pages 663-680

Safety of Urate-Lowering Therapies. Managing the Risks to Gain the Benefits.

Author keywords

Allopurinol; Febuxostat; Gout; Pelgoticase; Safety

Indexed keywords

ALLOPURINOL; AZATHIOPRINE; BENZBROMARONE; CAPTOPRIL; DIGOXIN; DIURETIC AGENT; FEBUXOSTAT; HYDROCORTISONE SODIUM SUCCINATE; LIVER ENZYME; MERCAPTOPURINE; METHYLPREDNISOLONE SODIUM SUCCINATE; PEGLOTICASE; PLACEBO; PROBENECID; SULFINPYRAZONE; URIC ACID; WARFARIN; XANTHINE OXIDASE INHIBITOR;

EID: 84868341088     PISSN: 0889857X     EISSN: 15583163     Source Type: Journal    
DOI: 10.1016/j.rdc.2012.08.008     Document Type: Review
Times cited : (18)

References (75)
  • 1
    • 80053497428 scopus 로고    scopus 로고
    • Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008
    • Zhu Y., Pandya B.J., Choi H.K. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum 2011, 63:3136-3141.
    • (2011) Arthritis Rheum , vol.63 , pp. 3136-3141
    • Zhu, Y.1    Pandya, B.J.2    Choi, H.K.3
  • 2
    • 0036844297 scopus 로고    scopus 로고
    • Epidemiology of gout: is the incidence rising?
    • Arromdee E., Michet C.J., Crowson C.S., et al. Epidemiology of gout: is the incidence rising?. J Rheumatol 2002, 29:2403-2406.
    • (2002) J Rheumatol , vol.29 , pp. 2403-2406
    • Arromdee, E.1    Michet, C.J.2    Crowson, C.S.3
  • 3
    • 55249083968 scopus 로고    scopus 로고
    • Epidemiology of gout
    • Weaver A.L. Epidemiology of gout. Cleve Clin J Med 2008, 75(Suppl 5):S9-12.
    • (2008) Cleve Clin J Med , vol.75 , Issue.SUPPL. 5
    • Weaver, A.L.1
  • 4
    • 57749198424 scopus 로고    scopus 로고
    • Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study
    • Driver J.A., Djousse L., Logroscino G., et al. Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study. BMJ 2008, 337:a2467.
    • (2008) BMJ , vol.337
    • Driver, J.A.1    Djousse, L.2    Logroscino, G.3
  • 5
    • 79953858141 scopus 로고    scopus 로고
    • Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence
    • Folsom A.R., Yatsuya H., Nettleton J.A., et al. Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J Am Coll Cardiol 2011, 57:1690-1696.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1690-1696
    • Folsom, A.R.1    Yatsuya, H.2    Nettleton, J.A.3
  • 6
    • 17644371344 scopus 로고    scopus 로고
    • Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study
    • Choi H.K., Atkinson K., Karlson E.W., et al. Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Arch Intern Med 2005, 165:742-748.
    • (2005) Arch Intern Med , vol.165 , pp. 742-748
    • Choi, H.K.1    Atkinson, K.2    Karlson, E.W.3
  • 7
    • 34548142983 scopus 로고    scopus 로고
    • Independent impact of gout on mortality and risk for coronary heart disease
    • Choi H.K., Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation 2007, 116:894-900.
    • (2007) Circulation , vol.116 , pp. 894-900
    • Choi, H.K.1    Curhan, G.2
  • 9
    • 79551674574 scopus 로고    scopus 로고
    • Prevalence of contraindications and prescription of pharmacologic therapies for gout
    • Keenan R.T., O'Brien W.R., Lee K.H., et al. Prevalence of contraindications and prescription of pharmacologic therapies for gout. Am J Med 2011, 124:155-163.
    • (2011) Am J Med , vol.124 , pp. 155-163
    • Keenan, R.T.1    O'Brien, W.R.2    Lee, K.H.3
  • 10
    • 84862687850 scopus 로고    scopus 로고
    • Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008
    • Zhu Y., Pandya B.J., Choi H.K. Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. Am J Med 2012, 125(7):679-687.e1.
    • (2012) Am J Med , vol.125 , Issue.7
    • Zhu, Y.1    Pandya, B.J.2    Choi, H.K.3
  • 11
    • 13344281990 scopus 로고    scopus 로고
    • Gout epidemiology: results from the UK General Practice Research Database, 1990-1999
    • Mikuls T.R., Farrar J.T., Bilker W.B., et al. Gout epidemiology: results from the UK General Practice Research Database, 1990-1999. Ann Rheum Dis 2005, 64:267-272.
    • (2005) Ann Rheum Dis , vol.64 , pp. 267-272
    • Mikuls, T.R.1    Farrar, J.T.2    Bilker, W.B.3
  • 12
    • 10144245945 scopus 로고    scopus 로고
    • Prevalence of comorbid conditions and prescription medication use among patients with gout and hyperuricemia in a managed care setting
    • Riedel A.A., Nelson M., Wallace K., et al. Prevalence of comorbid conditions and prescription medication use among patients with gout and hyperuricemia in a managed care setting. J Clin Rheumatol 2004, 10:308-314.
    • (2004) J Clin Rheumatol , vol.10 , pp. 308-314
    • Riedel, A.A.1    Nelson, M.2    Wallace, K.3
  • 14
    • 1542278065 scopus 로고
    • The clinical and metabolic effects of benemid in patients with gout
    • Talbott J.H., Bishop C., Norcross B.M., et al. The clinical and metabolic effects of benemid in patients with gout. Trans Assoc Am Physicians 1951, 64:372-377.
    • (1951) Trans Assoc Am Physicians , vol.64 , pp. 372-377
    • Talbott, J.H.1    Bishop, C.2    Norcross, B.M.3
  • 15
    • 33746174436 scopus 로고    scopus 로고
    • Serum urate levels and gout flares: analysis from managed care data
    • Sarawate C.A., Patel P.A., Schumacher H.R., et al. Serum urate levels and gout flares: analysis from managed care data. J Clin Rheumatol 2006, 12:61-65.
    • (2006) J Clin Rheumatol , vol.12 , pp. 61-65
    • Sarawate, C.A.1    Patel, P.A.2    Schumacher, H.R.3
  • 16
    • 33644687678 scopus 로고    scopus 로고
    • Medication errors with the use of allopurinol and colchicine: a retrospective study of a national, anonymous Internet-accessible error reporting system
    • Mikuls T.R., Curtis J.R., Allison J.J., et al. Medication errors with the use of allopurinol and colchicine: a retrospective study of a national, anonymous Internet-accessible error reporting system. J Rheumatol 2006, 33:562-566.
    • (2006) J Rheumatol , vol.33 , pp. 562-566
    • Mikuls, T.R.1    Curtis, J.R.2    Allison, J.J.3
  • 17
    • 24944435549 scopus 로고    scopus 로고
    • Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD)
    • Mikuls T.R., Farrar J.T., Bilker W.B., et al. Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD). Rheumatology (Oxford) 2005, 44:1038-1042.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 1038-1042
    • Mikuls, T.R.1    Farrar, J.T.2    Bilker, W.B.3
  • 18
    • 33745610176 scopus 로고    scopus 로고
    • Gout medication treatment patterns and adherence to standards of care from a managed care perspective
    • Sarawate C.A., Brewer K.K., Yang W., et al. Gout medication treatment patterns and adherence to standards of care from a managed care perspective. Mayo Clin Proc 2006, 81:925-934.
    • (2006) Mayo Clin Proc , vol.81 , pp. 925-934
    • Sarawate, C.A.1    Brewer, K.K.2    Yang, W.3
  • 19
    • 0037103137 scopus 로고    scopus 로고
    • Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout
    • Perez-Ruiz F., Calabozo M., Pijoan J.I., et al. Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout. Arthritis Rheum 2002, 47:356-360.
    • (2002) Arthritis Rheum , vol.47 , pp. 356-360
    • Perez-Ruiz, F.1    Calabozo, M.2    Pijoan, J.I.3
  • 20
    • 84862104393 scopus 로고    scopus 로고
    • Communicating the risks of medicine: time to move forward
    • Dal Pan G.J. Communicating the risks of medicine: time to move forward. Med Care 2012, 50:463-465.
    • (2012) Med Care , vol.50 , pp. 463-465
    • Dal Pan, G.J.1
  • 21
    • 48249152146 scopus 로고    scopus 로고
    • Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies
    • Kongkaew C., Noyce P.R., Ashcroft D.M. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother 2008, 42:1017-1025.
    • (2008) Ann Pharmacother , vol.42 , pp. 1017-1025
    • Kongkaew, C.1    Noyce, P.R.2    Ashcroft, D.M.3
  • 22
    • 79952777768 scopus 로고    scopus 로고
    • Long-term therapy for chronic gout results in clinically important improvements in the health-related quality of life: short form-36 is responsive to change in chronic gout
    • Khanna P.P., Perez-Ruiz F., Maranian P., et al. Long-term therapy for chronic gout results in clinically important improvements in the health-related quality of life: short form-36 is responsive to change in chronic gout. Rheumatology (Oxford) 2011, 50:740-745.
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 740-745
    • Khanna, P.P.1    Perez-Ruiz, F.2    Maranian, P.3
  • 23
    • 79961132862 scopus 로고    scopus 로고
    • Difficult-to-treat gouty arthritis: a disease warranting better management
    • Schlesinger N. Difficult-to-treat gouty arthritis: a disease warranting better management. Drugs 2011, 71:1413-1439.
    • (2011) Drugs , vol.71 , pp. 1413-1439
    • Schlesinger, N.1
  • 24
    • 84870250393 scopus 로고    scopus 로고
    • Comorbidity burden, healthcare resource utilization, and costs in chronic gout patients refractory to conventional urate-lowering therapy
    • [Epub ahead of print]
    • Wu E.Q., Forsythe A., Guerin A., et al. Comorbidity burden, healthcare resource utilization, and costs in chronic gout patients refractory to conventional urate-lowering therapy. Am J Ther 2011, [Epub ahead of print].
    • (2011) Am J Ther
    • Wu, E.Q.1    Forsythe, A.2    Guerin, A.3
  • 25
    • 33644631485 scopus 로고    scopus 로고
    • Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol
    • Pacher P., Nivorozhkin A., Szabo C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 2006, 58:87-114.
    • (2006) Pharmacol Rev , vol.58 , pp. 87-114
    • Pacher, P.1    Nivorozhkin, A.2    Szabo, C.3
  • 26
    • 79955565930 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout
    • Stocker S.L., Graham G.G., McLachlan A.J., et al. Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout. J Rheumatol 2011, 38:904-910.
    • (2011) J Rheumatol , vol.38 , pp. 904-910
    • Stocker, S.L.1    Graham, G.G.2    McLachlan, A.J.3
  • 27
    • 0021345170 scopus 로고
    • Fatal Stevens-Johnson syndrome in a patient on captopril and allopurinol
    • Pennell D.J., Nunan T.O., O'Doherty M.J., et al. Fatal Stevens-Johnson syndrome in a patient on captopril and allopurinol. Lancet 1984, 1:463.
    • (1984) Lancet , vol.1 , pp. 463
    • Pennell, D.J.1    Nunan, T.O.2    O'Doherty, M.J.3
  • 28
    • 0021354236 scopus 로고
    • Fever, myalgia, and arthralgia in a patient on captopril and allopurinol
    • Samanta A., Burden A.C. Fever, myalgia, and arthralgia in a patient on captopril and allopurinol. Lancet 1984, 1:679.
    • (1984) Lancet , vol.1 , pp. 679
    • Samanta, A.1    Burden, A.C.2
  • 29
    • 0029164649 scopus 로고
    • Allopurinol and enalapril. Drug induced anaphylactic coronary spasm and acute myocardial infarction
    • Ahmad S. Allopurinol and enalapril. Drug induced anaphylactic coronary spasm and acute myocardial infarction. Chest 1995, 108:586.
    • (1995) Chest , vol.108 , pp. 586
    • Ahmad, S.1
  • 30
    • 84864486646 scopus 로고    scopus 로고
    • Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol
    • Stamp L.K., Taylor W.J., Jones P.B., et al. Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol. Arthritis Rheum 2012, 64(8):2529-2536.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2529-2536
    • Stamp, L.K.1    Taylor, W.J.2    Jones, P.B.3
  • 31
    • 84877093237 scopus 로고    scopus 로고
    • The incidence of allopurinol hypersensitivity syndrome: a population perspective
    • Khanna D., Fuldeore M.J., Meissner B.L., et al. The incidence of allopurinol hypersensitivity syndrome: a population perspective. Arthritis Rheum 2008, 60:S542.
    • (2008) Arthritis Rheum , vol.60
    • Khanna, D.1    Fuldeore, M.J.2    Meissner, B.L.3
  • 32
    • 0018595189 scopus 로고
    • Severe hypersensitivity reactions to allopurinol
    • Lang P.G. Severe hypersensitivity reactions to allopurinol. South Med J 1979, 72:1361-1368.
    • (1979) South Med J , vol.72 , pp. 1361-1368
    • Lang, P.G.1
  • 33
    • 70249122727 scopus 로고    scopus 로고
    • Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    • Tassaneeyakul W., Jantararoungtong T., Chen P., et al. Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics 2009, 19:704-709.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 704-709
    • Tassaneeyakul, W.1    Jantararoungtong, T.2    Chen, P.3
  • 34
    • 34748917556 scopus 로고    scopus 로고
    • Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events
    • Dalbeth N., Stamp L. Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events. Semin Dial 2007, 20:391-395.
    • (2007) Semin Dial , vol.20 , pp. 391-395
    • Dalbeth, N.1    Stamp, L.2
  • 35
    • 44149110334 scopus 로고    scopus 로고
    • Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?
    • Lee H.Y., Ariyasinghe J.T., Thirumoorthy T. Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?. Singapore Med J 2008, 49:384-387.
    • (2008) Singapore Med J , vol.49 , pp. 384-387
    • Lee, H.Y.1    Ariyasinghe, J.T.2    Thirumoorthy, T.3
  • 36
    • 0032847798 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects
    • Turnheim K., Krivanek P., Oberbauer R. Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects. Br J Clin Pharmacol 1999, 48:501-509.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 501-509
    • Turnheim, K.1    Krivanek, P.2    Oberbauer, R.3
  • 37
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • Hung S.I., Chung W.H., Liou L.B., et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A 2005, 102:4134-4139.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4134-4139
    • Hung, S.I.1    Chung, W.H.2    Liou, L.B.3
  • 38
    • 38149108354 scopus 로고    scopus 로고
    • A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
    • Lonjou C., Borot N., Sekula P., et al. A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 2008, 18:99-107.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 99-107
    • Lonjou, C.1    Borot, N.2    Sekula, P.3
  • 39
    • 61549115662 scopus 로고    scopus 로고
    • HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis
    • Kaniwa N., Saito Y., Aihara M., et al. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics 2008, 9:1617-1622.
    • (2008) Pharmacogenomics , vol.9 , pp. 1617-1622
    • Kaniwa, N.1    Saito, Y.2    Aihara, M.3
  • 40
    • 79955464425 scopus 로고    scopus 로고
    • Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
    • Kang H.R., Jee Y.K., Kim Y.S., et al. Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans. Pharmacogenet Genomics 2011, 21:303-307.
    • (2011) Pharmacogenet Genomics , vol.21 , pp. 303-307
    • Kang, H.R.1    Jee, Y.K.2    Kim, Y.S.3
  • 41
    • 1542614443 scopus 로고    scopus 로고
    • Cardiovascular drugs and serum uric acid
    • Reyes A.J. Cardiovascular drugs and serum uric acid. Cardiovasc Drugs Ther 2003, 17:397-414.
    • (2003) Cardiovasc Drugs Ther , vol.17 , pp. 397-414
    • Reyes, A.J.1
  • 42
    • 0021366307 scopus 로고
    • Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency
    • Hande K.R., Noone R.M., Stone W.J. Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am J Med 1984, 76:47-56.
    • (1984) Am J Med , vol.76 , pp. 47-56
    • Hande, K.R.1    Noone, R.M.2    Stone, W.J.3
  • 43
    • 0035112818 scopus 로고    scopus 로고
    • Effect of furosemide on renal excretion of oxypurinol and purine bases
    • Yamamoto T., Moriwaki Y., Takahashi S., et al. Effect of furosemide on renal excretion of oxypurinol and purine bases. Metabolism 2001, 50:241-245.
    • (2001) Metabolism , vol.50 , pp. 241-245
    • Yamamoto, T.1    Moriwaki, Y.2    Takahashi, S.3
  • 44
    • 84865346674 scopus 로고    scopus 로고
    • Furosemide increases plasma oxypurinol without lowering serum urate-a complex drug interaction: implications for clinical practice
    • Stamp L.K., Barclay M.L., O'Donnell J.L., et al. Furosemide increases plasma oxypurinol without lowering serum urate-a complex drug interaction: implications for clinical practice. Rheumatology (Oxford) 2012, 51(9):1670-1676.
    • (2012) Rheumatology (Oxford) , vol.51 , Issue.9 , pp. 1670-1676
    • Stamp, L.K.1    Barclay, M.L.2    O'Donnell, J.L.3
  • 45
    • 80052037135 scopus 로고    scopus 로고
    • Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level
    • Stamp L.K., Barclay M.L., O'Donnell J.L., et al. Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level. Clin Pharmacol Ther 2011, 90:392-398.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 392-398
    • Stamp, L.K.1    Barclay, M.L.2    O'Donnell, J.L.3
  • 46
    • 0030584230 scopus 로고    scopus 로고
    • The management of gout
    • Emmerson B.T. The management of gout. N Engl J Med 1996, 334:445-451.
    • (1996) N Engl J Med , vol.334 , pp. 445-451
    • Emmerson, B.T.1
  • 47
    • 0023473492 scopus 로고
    • Plasma oxipurinol concentrations during allopurinol therapy
    • Emmerson B.T., Gordon R.B., Cross M., et al. Plasma oxipurinol concentrations during allopurinol therapy. Br J Rheumatol 1987, 26:445-449.
    • (1987) Br J Rheumatol , vol.26 , pp. 445-449
    • Emmerson, B.T.1    Gordon, R.B.2    Cross, M.3
  • 48
    • 33746717478 scopus 로고    scopus 로고
    • Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout
    • Dalbeth N., Kumar S., Stamp L., et al. Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout. J Rheumatol 2006, 33:1646-1650.
    • (2006) J Rheumatol , vol.33 , pp. 1646-1650
    • Dalbeth, N.1    Kumar, S.2    Stamp, L.3
  • 49
    • 0034827359 scopus 로고    scopus 로고
    • Relation between adverse events associated with allopurinol and renal function in patients with gout
    • Vazquez-Mellado J., Morales E.M., Pacheco-Tena C., et al. Relation between adverse events associated with allopurinol and renal function in patients with gout. Ann Rheum Dis 2001, 60:981-983.
    • (2001) Ann Rheum Dis , vol.60 , pp. 981-983
    • Vazquez-Mellado, J.1    Morales, E.M.2    Pacheco-Tena, C.3
  • 50
    • 0023875516 scopus 로고
    • Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol
    • Emmerson B.T., Hazelton R.A., Frazer I.H. Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol. Arthritis Rheum 1988, 31:436-440.
    • (1988) Arthritis Rheum , vol.31 , pp. 436-440
    • Emmerson, B.T.1    Hazelton, R.A.2    Frazer, I.H.3
  • 51
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • Becker M.A., Schumacher H.R., Wortmann R.L., et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005, 353:2450-2461.
    • (2005) N Engl J Med , vol.353 , pp. 2450-2461
    • Becker, M.A.1    Schumacher, H.R.2    Wortmann, R.L.3
  • 52
    • 56049101851 scopus 로고    scopus 로고
    • Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial
    • Schumacher H.R., Becker M.A., Wortmann R.L., et al. Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial. Arthritis Rheum 2008, 59:1540-1548.
    • (2008) Arthritis Rheum , vol.59 , pp. 1540-1548
    • Schumacher, H.R.1    Becker, M.A.2    Wortmann, R.L.3
  • 53
    • 77953729446 scopus 로고    scopus 로고
    • The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    • Becker M.A., Schumacher H.R., Espinoza L.R., et al. The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther 2010, 12:R63.
    • (2010) Arthritis Res Ther , vol.12
    • Becker, M.A.1    Schumacher, H.R.2    Espinoza, L.R.3
  • 54
    • 13444257733 scopus 로고    scopus 로고
    • Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
    • Takano Y., Hase-Aoki K., Horiuchi H., et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci 2005, 76:1835-1847.
    • (2005) Life Sci , vol.76 , pp. 1835-1847
    • Takano, Y.1    Hase-Aoki, K.2    Horiuchi, H.3
  • 55
    • 68249124507 scopus 로고    scopus 로고
    • Febuxostat: a new agent for lowering serum urate
    • Keenan R.T., Pillinger M.H. Febuxostat: a new agent for lowering serum urate. Drugs Today (Barc) 2009, 45:247-260.
    • (2009) Drugs Today (Barc) , vol.45 , pp. 247-260
    • Keenan, R.T.1    Pillinger, M.H.2
  • 56
    • 42249100324 scopus 로고    scopus 로고
    • In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition
    • Mukoyoshi M., Nishimura S., Hoshide S., et al. In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica 2008, 38:496-510.
    • (2008) Xenobiotica , vol.38 , pp. 496-510
    • Mukoyoshi, M.1    Nishimura, S.2    Hoshide, S.3
  • 57
    • 84877094388 scopus 로고    scopus 로고
    • Effect of febuxostat on renal function in patients with gout and moderate to severe renal impairment
    • Available at: Accessed July 30, 2012.
    • Effect of febuxostat on renal function in patients with gout and moderate to severe renal impairment. 2012. Available at: Accessed July 30, 2012. http://clinicaltrials.gov/ct2/show/NCT01082640%3Fterm%3Dfebuxostat%26rank%3D4.
    • (2012)
  • 58
    • 80052337433 scopus 로고    scopus 로고
    • Safety and efficacy of febuxostat treatment in subjects with gout and severe allopurinol adverse reactions
    • Chohan S. Safety and efficacy of febuxostat treatment in subjects with gout and severe allopurinol adverse reactions. J Rheumatol 2011, 38:1957-1959.
    • (2011) J Rheumatol , vol.38 , pp. 1957-1959
    • Chohan, S.1
  • 59
    • 74549197894 scopus 로고    scopus 로고
    • Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout
    • Ernst M.E., Fravel M.A. Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout. Clin Ther 2009, 31:2503-2518.
    • (2009) Clin Ther , vol.31 , pp. 2503-2518
    • Ernst, M.E.1    Fravel, M.A.2
  • 60
    • 83555164596 scopus 로고    scopus 로고
    • A cardiovascular safety study of LibiGel (testosterone gel) in postmenopausal women with elevated cardiovascular risk and hypoactive sexual desire disorder
    • White W.B., Grady D., Giudice L.C., et al. A cardiovascular safety study of LibiGel (testosterone gel) in postmenopausal women with elevated cardiovascular risk and hypoactive sexual desire disorder. Am Heart J 2012, 163:27-32.
    • (2012) Am Heart J , vol.163 , pp. 27-32
    • White, W.B.1    Grady, D.2    Giudice, L.C.3
  • 62
    • 33947119693 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout
    • Sundy J.S., Ganson N.J., Kelly S.J., et al. Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. Arthritis Rheum 2007, 56:1021-1028.
    • (2007) Arthritis Rheum , vol.56 , pp. 1021-1028
    • Sundy, J.S.1    Ganson, N.J.2    Kelly, S.J.3
  • 63
    • 77956269930 scopus 로고    scopus 로고
    • Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo
    • Hershfield M.S., Roberts L.J., Ganson N.J., et al. Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proc Natl Acad Sci U S A 2010, 107:14351-14356.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14351-14356
    • Hershfield, M.S.1    Roberts, L.J.2    Ganson, N.J.3
  • 64
    • 80051749331 scopus 로고    scopus 로고
    • Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials
    • Sundy J.S., Baraf H.S., Yood R.A., et al. Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials. JAMA 2011, 306:711-720.
    • (2011) JAMA , vol.306 , pp. 711-720
    • Sundy, J.S.1    Baraf, H.S.2    Yood, R.A.3
  • 65
    • 33645004715 scopus 로고    scopus 로고
    • Second symposium on the definition and management of anaphylaxis: summary report-second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    • Sampson H.A., Munoz-Furlong A., Campbell R.L., et al. Second symposium on the definition and management of anaphylaxis: summary report-second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med 2006, 47:373-380.
    • (2006) Ann Emerg Med , vol.47 , pp. 373-380
    • Sampson, H.A.1    Munoz-Furlong, A.2    Campbell, R.L.3
  • 66
    • 51849118368 scopus 로고    scopus 로고
    • Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study
    • Sundy J.S., Becker M.A., Baraf H.S., et al. Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study. Arthritis Rheum 2008, 58:2882-2891.
    • (2008) Arthritis Rheum , vol.58 , pp. 2882-2891
    • Sundy, J.S.1    Becker, M.A.2    Baraf, H.S.3
  • 67
    • 33748608331 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • Zhang W., Doherty M., Bardin T., et al. EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006, 65:1312-1324.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1312-1324
    • Zhang, W.1    Doherty, M.2    Bardin, T.3
  • 68
    • 33847187129 scopus 로고
    • Probenecid (benemid); its uses and side-effects in 2,502 patients
    • Boger W.P., Strickland S.C. Probenecid (benemid); its uses and side-effects in 2,502 patients. AMA Arch Intern Med 1955, 95:83-92.
    • (1955) AMA Arch Intern Med , vol.95 , pp. 83-92
    • Boger, W.P.1    Strickland, S.C.2
  • 70
    • 58449135143 scopus 로고    scopus 로고
    • Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol
    • Reinders M.K., van Roon E.N., Jansen T.L., et al. Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol. Ann Rheum Dis 2009, 68:51-56.
    • (2009) Ann Rheum Dis , vol.68 , pp. 51-56
    • Reinders, M.K.1    van Roon, E.N.2    Jansen, T.L.3
  • 71
    • 84877098339 scopus 로고    scopus 로고
    • Available at: Accessed June 23, 2012.
    • Probenecid prescribing information. 2012. Available at: Accessed June 23, 2012. http://dailymed.nlm.nih.gov/dailymed/lookup.cfm%3Fsetid%3D5ca3dd4c-b8b4-4131-a066-214dabb2576f%23nlm34067-9.
    • (2012) Probenecid prescribing information
  • 72
    • 0031686146 scopus 로고    scopus 로고
    • Gout in the elderly. Clinical presentation and treatment
    • Fam A.G. Gout in the elderly. Clinical presentation and treatment. Drugs Aging 1998, 13:229-243.
    • (1998) Drugs Aging , vol.13 , pp. 229-243
    • Fam, A.G.1
  • 74
    • 84877088548 scopus 로고    scopus 로고
    • Allopurinol: drug information: Lexicomp; Available at: Accessed July 29, 2012.
    • Allopurinol: drug information: Lexicomp; 2006. Available at: Accessed July 29, 2012. http://www.uptodate.com/crlsql/interact/frameset.jsp.
    • (2006)
  • 75


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