Structure-activity relationships of polyphenols inhibiting lipopolysaccharide-induced NF-κB activation

Journal of the Korean Society for Applied Biological Chemistry

Volumn 55, Issue 5, 2012, Pages 669-675

  Shin, Soon Young ^a   Ahn, Seunghyun ^b   Park, Mi Joo ^a   Yoon, Hyuk ^a   Kim, Mihyang ^a   Ji, Sang Yun ^c   Koh, Dongsoo ^b   Lee, Young Han ^a   Lim, Yoongho ^a  

^a Konkuk University   (South Korea)

^b Dongduk Women's University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

2H chromene; chalcone; flavonoid; N phenylacetamide; polyphenol; structure activity relationships

Indexed keywords

BACTERIA (MICROORGANISMS);

EID: 84868334441     PISSN: 17382203     EISSN: 2234344X     Source Type: Journal    
DOI: 10.1007/s13765-012-2093-6     Document Type: Article

References (16)

1. Abdel-Aziz M and Abdel-Rahman HM (2010) Synthesis and antimycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives. Eur J Med Chem45, 3384-3388.
2. Caddick S, Muskett FW, Stoneman RG, and Woolfson DN (2006) Synthetic ligands for apo-neocarzinostatin. J Am Chem Soc128, 4204-4205.
3. Czeh M, Gressens P, and Kaindl AM (2011) The yin and yang of microglia. Dev Neurosci33, 199-209.
4. Fraga CG (2010) Plant phenolics and human health. John Wiley and Sons, USA.
5. Graeber MB and Streit WJ (2010) Microglia: biology and pathology. Acta Neuropathol119, 89-105.
6. Hwang D, Hyun J, Jo G, Koh D, and Lim Y (2011) Synthesis and complete assignment of NMR data of 20 chalcones. Magn Reson Chem49, 41-45.
7. Hyun J, Woo Y, Hwang DS, Jo G, Eom S, Lee Y et al. (2010) Relationships between structures of hydroxyflavones and their antioxidative effects. Bioorg Med Chem Lett20, 5510-5513.
8. Kim SU and de Vellis J (2005) Microglia in health and disease. J Neurosci Res81, 302-313.
9. Nazarian Z, Emami S, Heydari S, Ardestani SK, Nakhjiri M, Poorrajab F et al. (2010) Novel antileishmanial chalconoids: Synthesis and biological activity of 1- or 3-(6-chloro-2H-chromen-3-yl)propen-1-ones. Eur J Med Chem45, 1424-1429.
10. Nimmo AJ and Vink R (2009) The management of inflammation in the central nervous system. Recent Pat CNS Drug Discov4, 86-95.
11. Pirhadi S and Ghasemi JB (2010) 3D-QSAR analysis of human immunodeficiency virus entry-1 inhibitors by CoMFA and CoMSIA. Eur J Med Chem45, 4897-4903.
12. Ren J, Chamberlain PP, Stamp A, Short SA, Weaver KL, Romines KR et al. (2008) Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J Med Chem51, 5000-5008.
13. Shin SY, Woo Y, Hyun J, Yong Y, Koh D, Lee YH et al. (2011) Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. Bioorg Med Chem Lett21, 6036-6041.
14. Srinivasan B, Johnson TE, Lad R, and Xing C (2009) StructureActivity Relationship Studies of Chalcone Leading to 3-Hydroxy-4, 3, 4, 5-tetramethoxychalcone and Its Analogues as Potent Nuclear Factor κB Inhibitors and Their Anticancer Activities. J Med Chem52, 7228-7235.
15. Woo Y, Shin SY, Hyun J, Lee SD, Lee YH, and Lim Y (2012) Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells. Int J Mol Med29, 403-408.
16. Zubieta C, He XZ, Dixon RA, and Noel JP (2001) Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nature Struc Biol8, 271-279.