Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution

Journal of Controlled Release

Volumn 59, Issue 1, 1999, Pages 15-22

  Ogawara, Ken Ichi ^a   Yoshida, Minoru ^a   Higaki, Kazutaka ^a   Toshikiro Kimura, ^a   Shiraishi, Keiko ^b   Nishikawa, Makiya ^b   Takakura, Yoshinobu ^b   Hashida, Mitsuru ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Particle size; Pharmacokinetics; Polystyrene microsphere; Reticuloendothelial system; Untrahepatic distribution

Indexed keywords

MICROSPHERE; POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISPOSITION; INTRAVENOUS DRUG ADMINISTRATION; KUPFFER CELL; LIVER SINUSOID; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION;

ANIMALS; ENDOTHELIUM; INJECTIONS, INTRAVENOUS; KUPFFER CELLS; LIVER; MALE; MICROSPHERES; PARTICLE SIZE; POLYSTYRENES; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 0032919807     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00015-2     Document Type: Article

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