Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 5, 2012, Pages 604-613

  Lu, Qing ^a   Newton, Julie ^a   Hsiao, Vivian ^a   Shamirian, Paul ^a   Blackburn, Michael R ^b   Pedroza, Mesias ^b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Adenosine deaminase; Equilibrative nucleoside transporters; MAP kinases; Oxidative stress; RhoA

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; ACETYLCYSTEINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE INHIBITOR; APOCYNIN; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; DIPYRIDAMOLE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; JANUS KINASE; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE TRANSPORTER; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; CYTOPLASM; ENZYME ACTIVATION; ENZYME INHIBITION; LUNG ENDOTHELIUM; LUNG ENDOTHELIUM BARRIER DYSFUNCTION; MITOCHONDRION; NONHUMAN; NUCLEOSIDE TRANSPORT; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION;

ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE DEAMINASE INHIBITORS; ADHERENS JUNCTIONS; ANIMALS; APOPTOSIS; CAPILLARY PERMEABILITY; CATTLE; CELLS, CULTURED; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIA, MUSCLE; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PENTOSTATIN; PULMONARY ARTERY; RATS; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STRESS FIBERS;

EID: 84868330454     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0012OC     Document Type: Article

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