Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Wahome, Paul G ^a   Ahlawat, Sarita ^a   Mantis, Nicholas J ^a,b  

^a WADSWORTH CENTER   (United States)

^b UNIVERSITY AT ALBANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (FURAN 2 YL) 5 [2 (FURAN 2 YL)ETHENYL] 3,4 DIHYDROPYRAZOL 2 YL] 2 (1H 1,2,4 TRIAZOL 5 YLSULFANYL)ETHANONE; 1 [3 (FURAN 2 YL) 7 (FURAN 2 YLMETHYLIDENE) 3A,4,5,6 TETRAHYDRO 3H INDAZOL 2 YL] 2 (1H 1,2,4 TRIAZOL 5 YLSULFANYL)ETHANONE; 2 [5 (3 PYRIDINYL) 1H PYRAZOL 4 YL]QUINOLINE; 3 (5 PHENYL 1H PYRAZOL 4 YL)PYRIDINE; 4 (3 PYRIDIN 2 YL) 1H PYRAZOL 4 YLQUINOLINE; 4 (5 PHENYL 1H PYRAZOL 4 YL)PYRIDINE; 4 (5 PYRIDIN 3 YL 1H PYRAZOL 4 YL)QUINOLINE; 6 OXO N (1 PHENYLBUTAN 2 YL)5H BENZO[B][1,4]BENZOTHIAZEPINE 3 CARBOXAMIDE; 6 OXO N (4 PHENYLBUTAN 2 YL) 5H BENZO[B][1,4]BENZOTHIAZEPINE 3 CARBOXAMIDE; CASPASE 3; CASPASE 7; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTECTIVE AGENT; PW 66; PW 66B; PW 66C; PW 66D; PW 66E; PW 69; PW 69B; PW 72; PW 72B; RICIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS INHIBITION; PROTEIN TERTIARY STRUCTURE; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG DESIGN; DRUG EFFECT; HUMAN; INFLAMMATION; METABOLISM; METHODOLOGY; PROTEIN SYNTHESIS; RABBIT; RIBOSOME; SIGNAL TRANSDUCTION; VERO CELL;

BACTERIA (MICROORGANISMS);

ANIMALS; CASPASE 3; CASPASE 7; CELL DEATH; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INFLAMMATION; MACROPHAGES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BIOSYNTHESIS; RABBITS; RIBOSOMES; RICIN; SIGNAL TRANSDUCTION; VERO CELLS;

EID: 84868328200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049075     Document Type: Article

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