The X-ray structure of ricin A chain with a novel inhibitor

Archives of Biochemistry and Biophysics

Volumn 483, Issue 1, 2009, Pages 23-28

  Bai, Yan ^a   Monzingo, Arthur F ^a   Robertus, Jon D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Inhibitor; Pyrimidines; Ricin; Virtual screen; X ray structure

Indexed keywords

PROTEIN INHIBITOR; PYRIMIDINE DERIVATIVE; RICIN A;

ARTICLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; STRUCTURE ANALYSIS; X RAY ANALYSIS;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RICIN; STRUCTURE-ACTIVITY RELATIONSHIP; USER-COMPUTER INTERFACE;

EUKARYOTA;

EID: 60049091766     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.12.013     Document Type: Article

References (42)

1. Stirpe F., and Barbieri L. FEBS Lett. 195 (1986) 1-8
2. Sandvig K., and van Deurs B. FEBS Lett. 529 (2002) 49-53
3. Endo Y., and Tsurugi K. J. Biol. Chem. 263 (1988) 8735-8739
4. Endo Y., and Tsurugi K. J. Biol. Chem. 262 (1987) 8128-8130
5. D.R. Franz, N.K. Jaax, Ricin toxin, in: Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare, Office of the Surgeon General, Department of the Army, United States of America, 1997.
6. C. De Fiebre, in: Minneapolis Star-Tribune, Minneapolis, MN, 1995, p. 1B.
7. A. Loyd, M. Fletcher, in: London Times, London, England, 2001.
8. Chen X.Y., Link T.M., and Schramm V.L. Biochemistry 37 (1998) 11605-11613
9. Roday S., Amukele T., Evans G.B., Tyler P.C., Furneaux R.H., and Schramm V.L. Biochemistry 43 (2004) 4923-4933
10. Sturm M.B., Roday S., and Schramm V.L. J. Am. Chem. Soc. 129 (2007) 5544-5550
11. Wang S., Feng J., Guo J., Li Y., Sun Y., Qin W., Hu M., and Shen B. Int. J. Pept. Res. Ther. 11 (2005) 211-218
12. Hesselberth J.R., Miller D., Robertus J., and Ellington A.D. J. Biol. Chem. 275 (2000) 4937-4942
13. Montfort W., Villafranca J.E., Monzingo A.F., Ernst S.R., Katzin B., Rutenber E., Xuong N.H., Hamlin R., and Robertus J.D. J. Biol. Chem. 262 (1987) 5398-5403
14. Rutenber E., Katzin B.J., Ernst S., Collins E.J., Mlsna D., Ready M.P., and Robertus J.D. Proteins 10 (1991) 240-250
15. Monzingo A.F., and Robertus J.D. J. Mol. Biol. 227 (1992) 1136-1145
16. Kim Y., Mlsna D., Monzingo A.F., Ready M.P., Frankel A., and Robertus J.D. Biochemistry 31 (1992) 3294-3296
17. Ready M.P., Kim Y., and Robertus J.D. Proteins 10 (1991) 270-278
18. Schlossman D., Withers D., Welsh P., Alexander A., Robertus J., and Frankel A. Mol. Cell. Biol. 9 (1989) 5012-5021
19. Yan X., Hollis T., Svinth M., Day P., Monzingo A.F., Milne G.W., and Robertus J.D. Structure-based identification of a ricin inhibitor. J. Mol. Biol. 266 (1997) 1043-1049
20. Miller M., Schneider J., Sathyanarayana B.K., Toth M.V., Marshall G.R., Clawson L., Selk L., Kent S.B., and Wlodawer A. Science 246 (1989) 1149-1152
21. Miller D.J., Ravikumar K., Shen H., Suh J.K., Kerwin S.M., and Robertus J.D. J. Med. Chem. 45 (2002) 90-98
22. Abagyan R.A., Totrov M., and Kuznetsov D. J. Comput. Chem. 15 (1994) 488-506
23. Abagyan R., and Totrov M. Curr. Opin. Chem. Biol. 5 (2001) 375-382
24. Irwin J.J., and Shoichet B.K. J. Chem. Inf. Model 45 (2005) 177-182
25. Robertus J.D., Piatak M., Ferris R., and Houston L.L. J. Biol. Chem. 262 (1987) 19-20
26. Mlsna D., Monzingo A.F., Katzin B.J., Ernst S., and Robertus J.D. Protein Sci. 2 (1993) 429-435
27. Otwinowski Z., and Minor W. Methods Enzymol. 27 (1997) 307-326
28. Vagin A., and Teplyakov A. J. Appl. Cryst. 30 (1997) 1022-1025
29. CCP4, Acta Cryst. D5 (1994) 760-763.
30. Murshudov G.N., Vagin A.A., and Dodson E.J. Acta Crystallogr. D Biol. Crystallogr. 53 (1997) 240-255
31. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., Read R.J., Rice L.M., Simonson T., and Warren G.L. Acta Crystallogr. D Biol. Crystallogr. 54 Pt 5 (1998) 905-921
32. Emsley P., and Cowtan K. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 2126-2132
33. Shoichet B.K. Nature 432 (2004) 862-865
34. Shoichet B.K., McGovern S.L., Wei B., and Irwin J.J. Curr. Opin. Chem. Biol. 6 (2002) 439-446
35. Doman T.N., McGovern S.L., Witherbee B.J., Kasten T.P., Kurumbail R., Stallings W.C., Connolly D.T., and Shoichet B.K. J. Med. Chem. 45 (2002) 2213-2221
36. Kellenberger E., Rodrigo J., Muller P., and Rognan D. Proteins 57 (2004) 225-242
37. Kontoyianni M., McClellan L.M., and Sokol G.S. J. Med. Chem. 47 (2004) 558-565
38. Perola E., Walters W.P., and Charifson P.S. Proteins 56 (2004) 235-249
39. Warren G.L., Andrews C.W., Capelli A.M., Clarke B., Lalonde J., Lambert M.H., Lindvall M., Nevins N., Semus S.F., Senger S., Tedesco G., Wall I.D., Woolven J.M., Peishoff C.E., and Head M.S. J. Med. Chem. 49 (2006) 5912-5931
40. Chen H., Lyne P.D., Giordanetto F., Lovell T., and Li J. J. Chem. Inf. Model 46 (2006) 401-415
41. Wallace A.C., Laskowski R.A., and Thornton J.M. Protein Eng. 8 (1995) 127-134
42. W. L. DeLano, in: DeLano Scientific, San Carlos, CA, 2002.