The use of MALDI-TOF-MS and in Silico studies for determination of antimicrobial peptides' affinity to bacterial cells

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 11, 2012, Pages 1939-1948

  Mandal, Santi M ^b   Migliolo, Ludovico ^a   Franco, Octavio L ^a  

^a Centro de Analises Proteomicas e Bioquimicas   (Brazil)

^b INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Affinity constant; Antimicrobial peptides screening; MALDI TOF MS; Molecular modeling

Indexed keywords

AFFINITY CONSTANTS; ANTIMICROBIAL DRUG; ANTIMICROBIAL PEPTIDE; BACTERIAL CELLS; BINDING AFFINITIES; BROAD SPECTRUM; HIGH THROUGHPUT; IN-SILICO; IN-VITRO; IN-VIVO; MALDI TOF MS; MEMBRANE BILAYERS; MOLECULAR DOCKING; SCREENING TOOL; THEORETICAL STUDY;

BINDING ENERGY; MOLECULAR MODELING; PEPTIDES; PHOSPHOLIPIDS;

INDUCTIVELY COUPLED PLASMA;

AMP 1; BACITRACIN; PHOSPHOLIPID; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL MEMBRANE; BILAYER MEMBRANE; BINDING AFFINITY; COMPUTER MODEL; DRUG BINDING; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; PROTEIN INTERACTION;

ANTIMICROBIAL CATIONIC PEPTIDES; COMPUTER SIMULATION; ESCHERICHIA COLI; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MODELS, MOLECULAR; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLGLYCEROLS; PROTEIN BINDING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 84868261398     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0453-4     Document Type: Article

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