Renoprotective effects of Moringa oleifera pods in 7,12-dimethylbenz [a] anthracene-exposed mice

Journal of Chinese Integrative Medicine

Volumn 10, Issue 10, 2012, Pages 1171-1178

  Sharma, Veena ^a   Paliwal, Ritu ^a   Janmeda, Pracheta ^a   Sharma, Shatruhan ^b  

^a BANASTHALI UNIVERSITY   (India)

^b Maa Anandmayee Institute   (India)

Author keywords

2 benzanthracene; 9,10 dimethyl l; Carcinogens; Cytotoxicity; Immunologic; Mice; Moringa oleifera; Plant extracts

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BUTYLATED HYDROXYANISOLE; CHOLESTEROL; CYTOCHROME B5; CYTOCHROME P450; FREE RADICAL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MORINGA OLEIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; KIDNEY DYSFUNCTION; KIDNEY PARENCHYMA; MALE; MORINGA OLEIFERA; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; RENAL PROTECTION; TRADITIONAL MEDICINE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; KIDNEY; MALE; MICE; MORINGA OLEIFERA; PLANT EXTRACTS;

EID: 84868237296     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20121015     Document Type: Article

References (34)

1. Sharma P, Parmar J, Verma P, Sharma P, Goyal PK. Chemopreventive effect of Phyllanthus niruri on DMBA induced skin papillomagenesis in Swiss albino mice[J]. Int J Biol Med Res, 2010, 1(4): 158-164.
2. Moringa oleifera Lam. on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice[J]. Asian Pac J Cancer Prev, 2003, 4(2): 131-139.
3. International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 3. Certain polycyclic aromatic hydrocarbons and heterocyclic compounds. Lyon: International Agency for Research on Cancer. 1973.
4. Internaitonal Agency of Research on Cancer. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 32. Polynuclear aromatic compounds, Part 1, chemical, environmental and experimental data. Lyon: International Agency for Research on Cancer. 1983.
5. International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans supplement. Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. Lyon: International Agency for Research on Cancer. 1987.
6. Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ[J]. Jpn J Pharmacol, 2001, 86(3): 302-309.
7. Lindhe O, Granberg L, Brandt I. Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands[J]. Arch Toxicol, 2002, 76(8): 460-466.
8. Buters J, Quintanilla-Martinez L, Schober W, Soballa VJ, Hintermair J, Wolff T, Gonzalez FJ, Greim H. CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity[J]. Carcinogenesis, 2003, 24(2): 327-334.
9. Paliwal R, Sharma V, Pracheta. A review on horse radish tree (Moringa oleifera): a multipurpose tree with high economic and commercial importance[J]. Asian J Biotechnol, 2011, 3(4): 317-328.
10. Moringa oleifera Lam. in amelioration of DMBA-induced renal carcinogenesis in Swiss albino mice[J]. Biol Med, 2011, 3(2): 27-35.
11. Paliwal R, Sharma V, Pracheta, Sharma SH. Hepatoprotective and antioxidant potential of Moringa oleifera pods against DMBA-induced hepatocarcinogenesis in male mice. Int J Drug Dev Res. 2011; 3(2): 128-138.
12. Paliwal R, Sharma V, Pracheta, Sharma S. Elucidation of free radical scavenging and antioxidant activity of aqueous and hydro-ethanolic extracts of Moringa oleifera pods. Res J Pharm Technol. 2011; 4(4): 566-571.
13. Moringa oleifera Lam. pods[J]. J Pharm Res, 2011, 4(2): 554-557.
14. Song LL, Myers SR, Lantvit D, Lubet RA, Steele VE, Kelloff GJ, Moon RC, Pezzuto JM. Chemoprevention of DMBA-induced mammary carcinogenesis: relationship between induction of phase II enzymes, effects on DMBA-induced hemoglobin adducts and decreases in mammary tumor multiplicity[J]. Polycycl Aromat Compd, 2000, 18(2): 193-210.
15. Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller DJ. Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy[J]. Biochem Pharmacol, 1984, 33(11): 1801-1807.
16. Omura T, Sato R. The carbon monoxide binding pigment of liver[J]. J Biol Chem, 1964, 239: 2370-2378.
17. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite[J]. Pharmacology, 1974, 11(3): 151-169.
18. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation[J]. J Biol Chem, 1974, 249(22): 7130-7139.
19. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases[J]. Am J Clin Pathol, 1957, 28(1): 56-63.
20. Sadashivam S, Manickam A. Biochemical methods[M]. New Delhi: New Age International Pvt Ltd Publishers, 2004. 193-194.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent[J]. J Biol Chem, 1951, 193(1): 265-275.
22. Zak B. Cholesterol methodologies: a review[J]. Clin Chem, 1977, 23(7): 1201-1214.
23. Pezzuto JM. Plant-derived anticancer agents[J]. Biochem Pharmacol, 1997, 53(2): 121-133.
24. Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods[J]. Free Radic Biol Med, 1999, 27(11-12): 1173-1181.
25. Izzotti A, Camoirano A, Cartiglia C, Grubbs CJ, Lubet RA, Kelloff GJ, De Flora S. Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents[J]. Cancer Res, 1999, 59(17): 4285-4290.
26. Bharali R, Azad MR, Tabassum J. Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice[J]. Indian J Physiol Pharmacol, 2003, 47(4): 459-464.
27. Parimalakrishnan S, Dey A, Manavalan R. Effect of methanolic extract of Cleome chelidonii on drug metabolising enzymes, antioxidant status and chemomodulatory efficacy of mice[J]. J Basic Appl Sci, 2009, 5(1): 37-46.
28. Bianchini F, Vainio H. Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ Health Perspect. 2001; 109(9): 893-902.
29. Fahmy H, Zjawiony JK, Konoshima T, Tokuda H, Khan S, Khalifa S. Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources[J]. Mar Drugs, 2006, 4(2): 28-36.
30. Liu J, Wang X, Shigenaga MK, Yeo HC, Mori A, Ames BN. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats[J]. FASEB J, 1996, 10(13): 1532-1538.
31. Preston TJ, Abadi A, Wilson L, Singh G. Mitochondrial contributions to cancer cell physiology: potential for drug development[J]. Adv Drug Deliv Rev, 2001, 49(1-2): 45-61.
32. Parmar J, Sharma P, Verma P, Sharma P, Goyal PK. Modulation of DMBA-induced biochemical and histopathological changes by Syzygium cumini seed extract during skin carcinogenesis[J]. Int J Curr Biomed Pharm Res, 2011, 1(2): 24-30.
33. Sharma V, Sharma A, Kansal L. The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice[J]. Food Chem Toxicol, 2010, 48(3): 928-936.
34. Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review[J]. Food Chem Toxicol, 2002, 40(8): 1091-1097.