Chemomodulatory effect of moringa oleifera, lam, on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice

Asian Pacific Journal of Cancer Prevention

Volumn 4, Issue 2, 2003, Pages 131-139

  Bharali, Rupjyoti ^a   Tabassum, Jawahira ^a   Azad, Mohammed Rekibul Haque ^a  

^a Department of Biotechnology ^*  (India)

Author keywords

Anti oxidant defense; Chemoprevention; DMBA; Hepatic biotransformation enzymes; Moringa oliefera lam; Skin papillomagenesis

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTIOXIDANT; CARCINOGEN; CYTOCHROME B5; CYTOCHROME P450; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; ENZYMOLOGY; FEMALE; LIVER; LIVER TUMOR; METABOLISM; MORINGA OLEIFERA; MOUSE; PAPILLOMA; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTIOXIDANTS; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; FEMALE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIVER; LIVER NEOPLASMS; MICE; MORINGA OLEIFERA; PAPILLOMA; PLANT EXTRACTS; SKIN NEOPLASMS;

EID: 0142245495     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Aebi H (1984). Catalase in vitro. In: Colowick SP, Kaplan NO, eds. Methods in Enzymology. Academic Press, New York, 105, 121-6.
2. Ashmawy MB (1999). The role of natural antioxidants and synthetic non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Saudi Pharma J, 7, 1-13.
3. Block G, Patterson B, Subar A (1992). Fruits, vegetables and cancer prevention: A review of the epidermiological evidence. Nutr Cancer, 2, 129.
4. Carlberg I, Mennervick B (1985). Glutathione reductase. In: Methods in Enzymology. Academic Press, New York, 113, 484-90.
5. Cordell GA, Farnvorth NR, Kinghorn CWW, et al (1992). Plant Derived Anti Cancer Agents for Therapy (abstr), 4th International Congress on Phytotherapy, PLI, Munich, Germany.
6. Dhar B, Gupta OP (1982). Nutritional value of Shigru Moringa oleifera Lam. Bull Med Ethnobot Res, 3, 280-8.
7. Dasgupta T, Banerjee S, Yadav PK, Rao AR (2001). Chemomodulation of carcinogen metabolizing enzymes, antioxidant profiles and skin and fore-stomach papillomagenesis by Spirulina platensis. Mol Cell Biochem, 226, 27-38.
8. Eilert V, Wolters B, Nahrstedt A (1981). The antibiotic principle of seeds of Moringa oleifera and Moringa stenopeta. J Med Plant Res, 42, 55-61.
9. Fry JR, Bridges JW (1975). Aryl mono-oxygenase activity in hepatic microsomes isolated by isoelectric precipitation. Anal Biochem, 67, 309-18.
10. Firozi PF, Aboobaker VS, Bhattacharya RK (1987). Action of vitamin A on DNA adduct formation by aflatoxin B in a microsome catalyzed reaction. Cancer Letters, 34, 213-20.
11. Faizi SB, Siddiqui R, Saleem S, Siddiqui KA, Gillani A (1994). Isolation and structure elucidation of new nitrite and mustard oil glycosides from Moringa oleifera and their effect or blood pressure. J Nat Prod, 57, 1256-61.
12. Geervani P, Devi A (1981). Influence of protein and fat on utilisation of carotene from drumstick (Moringa oleifera) leaves. Indian J Med Res, 74, 548-53.
13. Gaetam GE, Galnano S, Cenepa L et al (1989). Catalase and glutathione peroxidase are equally effective in detoxification of hydrogen peroxide in human erythrocytes. Blood, 73, 334-9.
14. Guenera PA, Vergas C, Milagros, UY (1996). Anti-inflammatory and Anti-tumor activities of Seed extracts of Malunggay, Moringa oleifera L (Moringaceae). Philli J Sc, 125, 175-84.
15. Habig WH, Pabst MJ, Jacoby WB (1974). Glutathione Strsnsferases - the first step in mercapturic acid formation. J Biol Chem, 249, 7130-9.
16. Jannu LN, Hussain SP, Rao AR (1990). Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA induced papillomagenesis in the skin of mice. Cancer Letters, 56, 59-63.
17. Ketterer B (1998). Glutathione-S-transferase and prevention of cellular free radical damage. Free Rad Res, 28, 647-58.
18. Kellof GJ, Crowell JA, Hawk ET, et al (1996). Clinical development plan: Indole-3-carbanol. J Cell Biochem, 26, 127-36.
19. Lowry OH, Rosenbrough NJ, Farr A, Randall RJ (1951). Protein measurement with the folin phenol reagent. J Biol Chem, 193, 265-75.
20. Lopez-Baria J, Barcena JA, Bocanegra JA, et al (1990). Structure, mechanism, functions and regulatory properties of glutathione reductase. In: J.V.B. Raton (Ed) Glutathione: Metabolism and physiological functions. CRC, FL, 105-116.
21. Marklund S, Marklund G (1974). Involvement of superoxide anion radical in auto-oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem, 47, 469-74.
22. Moron MA, Dipierrre JW, Mannervick B (1979). Levels of glutathione, glutathione reductase and glutathione Stransferase activity in rat lung and liver. Biochem. Biophys Acta, 582, 67-78.
23. Miller EC (1988). Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res, 38, 1479-96.
24. Majumdar UK, Gupta M, Chakrabarti S, Pal DK (1999). Evaluation of the hematological and hepatorenal functions of the methanolic extracts of Moringa oleifera Lam root treated mice. Indian. J Exp Biol, 37, 612-4.
25. Nishino H (1995). Cancer chemoprevention by natural carotenoids and their related compounds. J Cell Biochem, 22, 231-5.
26. Nakamura Y, Ohigashi H, Masuda S, et al (2000). Radox regulation of glutathione-S-transferase induction by benzyl isothiocyanate. Correlation of enzyme induction with the formation of reactive oxygen intermediates. Cancer Res, 60, 219-25.
27. Omura T, Sato R (1964). The carbon monoxide binding pigment of liver. J Biol Chem, 239, 2370-8.
28. Paglia DE, Velentine WM (1967). Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med, 70, 158-69.
29. Pezzuto JM (1997). Plant derived anti cancer agents. Biochem Pharmacol, 53, 121-33.
30. Steinmetz KA, Potter JD (1991). Vegetable, Fruit and Cancer. Epidemiology: Cancer Causes and Control, 2, 325-57.
31. Singh RP, Padmanathi B, Rao AR (2000). Modulatory influence of Adhatoda vesica (Justicia adhatoda) leaf extract on the enzymes of xenobiotic metabolism antioxidant status and lipid peroxidation in mice. Mol Cell Biochem, 213, 99-109.
32. Tanaka T, Kohno H, Mori H (2001). Chemoprevention of colon carcinogenesis by dietary non-nutritive compounds. Asian. Pacific. J Cancer Prevention, 2, 165-75.
33. Varshney R, Kale RK (1990). Effect of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. Int J Rad Biol, 58, 733-43.
34. Villa ML, Ferrario E, Trabattoni D, et al (1993). Retinoids, breast cancer and NK cells. Brit J Cancer, 68, 845-50.
35. Villasenor I (1994). Bioactive metabolites from Moringa oleifera Lam. Kimilia, 10, 47-52.
36. Wattenberg LW (1983). Inhibition of neoplasia by minor dietary constituents. Cancer Res, 43, 2448-53.
37. Wattenberg LW (1985). Chemoprevention of cancer. Cancer Res, 45, 1-8.
38. Wilkinson J, Clapper ML (1997). Detoxification enzymes and chemoprevention. Proc Soc Exp Biol Med, 216, 192-200.