Effect of ibuprofen on proliferation, differentiation, antigenic expression, and phagocytic capacity of osteoblasts

Journal of Bone and Mineral Metabolism

Volumn 30, Issue 5, 2012, Pages 554-560

  Díaz Rodríguez, Lourdes ^a   García Martínez, Olga ^a   De Luna Bertos, Elvira ^a   Ramos Torrecillas, Javier ^a   Ruiz, Concepción ^a,b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Bone tissue; Ibuprofen; Osteoblasts

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; HERMES ANTIGEN; HLA DR ANTIGEN; IBUPROFEN; MONOCLONAL ANTIBODY; OSTEOCALCIN;

ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOSARCOMA CELL; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS;

ANTIGENS, CD; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; HLA-DR ANTIGENS; HUMANS; IBUPROFEN; OSTEOBLASTS; OSTEOCALCIN; OSTEOSARCOMA; PHAGOCYTOSIS;

EID: 84868208935     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-012-0356-2     Document Type: Article

References (31)

1. Smith WL, Dewitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145-182
2. Beck A, Krischak G, Sorg T, Augat P, Farker K, Merkel U, Kinzl L, Claes L (2003) Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg 123:327-332
3. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA (2003) Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res 21:70-75
4. Evans CE, Butcher C (2004) The influence on human osteoblasts in vitro of nonsteroidal anti-inflammatory drugs which act on different cyclooxygenase enzymes. J Bone Joint Surg Br 86:444-449
5. Naruse T, Nishida Y, Hosono K, Ishiguro N (2006) Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. Carcinogenesis (Oxf) 27:584-592
6. Krischak GD, Augat P, Blakytny R, Claes L, Kinzl L, Beck A (2007) The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats. Arch Orthop Trauma Surg 127:453-458
7. Díaz-Rodríguez L, García-Martínez O, Arroyo-Morales M, Rodríguez-Pérez L, Rubio-Ruiz B, Ruiz C (2012) Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line. Biol Res Nurs 14:98-107
8. García-Martínez O, Díaz-Rodríguez L, De Luna-Bertos E, Reyes-Botella C, Ruiz C (2011) Effect of acetaminophen, ibuprofen and methylprednisolone on different parameters of human osteoblastlike cells. Arch Oral Biol 6:317-323
9. Chang JK, Wang GJ, Tsai ST, Ho ML (2005) Nonsteroidal antiinflammatory drug effects on osteoblastic cell cycle, cytotoxicity and cell death. Connect Tissue Res 46:200-210
10. Chang JK, Li CJ, Liao HJ, Wang CK, Wang GJ, Ho ML (2009) Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology 258:148-156
11. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van de Puete LBA, Lipsky PE (1998) Cyclooxygenase in biology and disease. FASEB J 12:1063-1073
12. Reyes-Botella C, Montes MJ, Vallecillo-Capilla MF, Olivares EG, Ruiz C (2000) Expression of molecules involved in antigen presentation and T cell activation (HLA-DR, CD80, CD86, CD44 and CD54) by cultured human osteoblasts. J Periodontol 71:614-617
13. Reyes-Botella C, Montes MJ, Vallecillo-Capilla MF, Olivares EG, Ruiz C (2002) Antigenic phenotype of cultured human osteoblast-like cells. Cell Physiol Biochem 12:359-364
14. Ruiz C, Pérez E, Vallecillo-Capilla MF, Reyes-Botella C (2003) Phagocytosis and allogeneic T cell stimulation by cultured human osteoblastic-like cells. Cell Physiol Biochem 13:309-314
15. Schrum LW, Bost KL, Hudson MC, Marriott I (2003) Bacterial infection induces expression of functional MHC class II molecules in murine and human osteoblasts. Bone (NY) 33:812-821
16. Pérez E, García-Martínez O, Arroyo-Morales M, Reyes-Botella C, Ruiz C (2006) Modulation of antigenic phenotype in cultured human osteoblast-like cells by FGFb, TGFβ1, PDGF-BB, IL-2, IL-1β, LPS and IFNγ. Biosci Rep 26:281-289
17. Stanley KT, Vandort C, Motyl C, Endres J, Fox DA (2006) Immunocompetent properties of human osteoblasts: interactions with T lymphocytes. J Bone Miner Res 21:29-36
18. García-Martínez O, Reyes-Botella C, Aguilera-Castillo O, Vallecillo-Capilla MF, Ruiz C (2006) Antigenic profile of osteoblasts present in human bone tissue sections. Biosci Rep 26:39-43
19. Díaz-Rodríguez L, García-Martínez O, Arroyo-Morales M, Reyes-Botella C, Ruiz C (2009) Antigenic phenotype and phagocytic capacity of MG63 osteosarcoma line. Ann N Y Acad Sci 1173(suppl 1):E46-E54
20. Prouillet C, Mazičre JC, Mazičre C, Wattel A, Brazier M, Kamel S (2004) Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol 67:1307-1313
21. Nayab SN, Jones FH, Olsen I (2005) Effects of calcium ion implantation on human bone cell interaction with titanium. Biomaterials 26:4717-4727
22. García-Martínez O, Reyes-Botella C, Díaz- Rodríguez L, De Luna-Bertos E, Ramos-Torrecillas J, Vallecillo-Capilla MF, Ruiz C (2011) Effect of platelet-rich plasma on growth and antigenic profile of human osteoblasts and its clinical impact. J Oral Maxillofac Surg. doi:10.1016/j.joms.2011.06.199
23. Vuolteenaho K, Moilanen T, Moilanen E (2008) Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process. Basic Clin Pharmacol Toxicol 102:10-14
24. Akman S, Gögüs A, Sener N, Bilgiç B, Aksov B, Seckin F (2002) Effect of diclofenac sodium on union of tibial fractures in rat. Adv Ther 19:119-125
25. Mullis BH, Copland ST, Weinhold PS, Miclau T, Lester GE, Bos DG (2006) Effect of COX-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury 37:827-837
26. Salari P, Abdollahi M (2009) Controversial effects of non-steroidal anti-inflammatory drugs on bone: a review. Inflamm Allergy Drug Targets 8:169-175
27. Abukawa H, Phelps M, Jackson P, Smith M, Vacanti JP, Kaban LB, Troulis MJ (2009) Effect of ibuprofen on osteoblast differentiation of porcine bone marrow-derived progenitor cells. J Oral Maxillofac Surg 67:2412-2417
28. Raisz LG, Pilbeam CC, Fall PM (1993) Prostaglandins: mechanisms of action and regulation in bone. Osteoporos Int 3(suppl 1): 136-140
29. Ruiz C, Pérez E, García-Martínez O, Díaz-Rodríguez L, Arroyo-Morales M, Reyes-Botella C (2007) Expression of cytokines IL-4, IL-12, IL-15, IL-18, and IFNγ and modulation by different growth factors in cultured human osteoblast-like cells. J Bone Miner Metab 25:286-292
30. Andreae S, Piras F, Burdin N, Triebel F (2002) Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J Immunol 168:3874-3880
31. Díaz-Rodríguez L, García-Martínez O, Arroyo-Morales M, Rubio-Ruiz B, Ruiz C (2010) Effect of paracetamol on human MG63 osteosarcoma cellular line. Acta Pharmacol Sin 31:1495-1499