Immunocompetent properties of human osteoblasts: Interactions with T lymphocytes

Journal of Bone and Mineral Research

Volumn 21, Issue 1, 2006, Pages 29-36

  Stanley, Katherine T ^a   Vandort, Christa ^a   Motyl, Christopher ^a   Endres, Judith ^a   Fox, David A ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b 5520 MSRB I ^*  (United States)

Author keywords

Cytokines; Inflammation; Integrins; Lymphocytes; Osteoblasts

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CD18 ANTIGEN; CD6 ANTIGEN; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; GAMMA INTERFERON; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 6; LIGAND; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE ANTIGEN;

ACCESSORY CELL; ANTIGEN PRESENTATION; ARTICLE; CELL INTERACTION; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IN VITRO STUDY; INFLAMMATION; JOINT DESTRUCTION; JOINT FRACTURE; OSTEOBLAST; OSTEOSARCOMA CELL; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; CELL COMMUNICATION; CELL LINE, TRANSFORMED; COCULTURE TECHNIQUES; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; OSTEOBLASTS; T-LYMPHOCYTES;

EID: 29644431787     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.051004     Document Type: Article

References (43)

1. Ducy P, Schinke T, Karsenty G 2000 The osteoblast: A sophisticated fibroblast under central surveillance. Science 289:1501-1504.
2. Gortz B, Hayer S, Redlich K, Zwerina J, Tohidast-Akrad M, Tuerk B, Hartmann C, Kollias G, Steiner G, Smolen JS, Schett G 2004 Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. J Bone Miner Res 19:990-998.
3. Tanaka Y, Mine S, Hanagiri T, Hiraga T, Morimoto I, Figdor CG, van Kooyk Y, Ozawa H, Nakamura T, Yasumoto K, Eto S 1998 Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cells. Cancer Res 58:4138-4145.
4. Lisignoli G, Toneguzzi S, Piacentini A, Cristino S, Cattini L, Grassi F, Facchini A 2004 Recruitment and proliferation of T lymphocytes is supported by IFNgamma- and TNFalpha-activated human osteoblasts: Involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor. J Cell Physiol 198:388-398.
5. Skjodt H, Moller T, Freiesleben SF 1989 Human osteoblast-like cells expressing MHC class II determinants stimulate allogeneic and autologous peripheral blood mononuclear cells and function as antigen-presenting cells. Immunology 68:416-420.
6. Chen XD, Qian HY, Neff L, Satomura K, Horowitz MC 1999 Thy-1 antigen expression by cells in the osteoblast lineage. J Bone Miner Res 14:362-375.
7. Skjodt H, Hughes DE, Dobson PR, Russell RG 1990 Constitutive and inducible expression of HLA class II determinants by human osteoblast-like cells in vitro. J Clin Invest 85:1421-1426.
8. Okada Y, Morimoto I, Ura K, Watanabe K, Eto S, Kumegawa M, Raisz L, Pilbeam C, Tanaka Y 2002 Cell-to-cell adhesion via intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-induced osteoclast differentiation and bone resorption. Endocr J 49:483-495.
9. Nelissen JM, Torensma R, Pluyter M, Adema GJ, Raymakers RA, van Kooyk Y, Figdor CG 2000 Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS. Exp Hematol 28:422-432.
10. Reyes-Botella C, Montes MJ, Vallecillo-Capilla MF, Olivares EG, Ruiz C 2000 Expression of molecules involved in antigen presentation and T cell activation (HLA-DR, CD80, CD86, CD44 and CD54) by cultured human osteoblasts. J Periodontol 71:614-617.
11. Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y 2001 Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 166:3574-3579.
12. Schrum LW, Bost KL, Hudson MC, Marriott I 2003 Bacterial infection induces expression of functional MHC class II molecules in murine and human osteoblasts. Bone 33:812-821.
13. Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Riccio M, Ferruzzi A, Gualtieri G, Facchini A 1999 Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 26:791-799.
14. Lisignoli G. Toneguzzi S, Piacentini A, Cattini L, Lenti A, Tschon M, Cristino S, Grassi F, Facchini A 2003 Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. J Cell Physiol 194:71-79.
15. Weir EC, Insogna KL, Horowitz MC 1989 Osteoblast-like cells secrete granulocyte-macrophage colony-stimulating factor in response to parathyroid hormone and lipopolysaccharide. Endocrinology 124:899-904.
16. Rifas L, Arackal S, Weitzmann MN 2003 Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. J Cell Biochem 88:650-659.
17. Thomson BM. Mundy GR, Chambers TJ 1987 Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunol 138:775-779.
18. Takeuchi Y, Fukumoto S, Matsumoto T 1995 Relationship between actions of transforming growth factor (TGF)-beta and cell surface expression of its receptors in clonal osteoblastic cells. J Cell Physiol 162:315-321.
19. Ishibashi H, Karube S, Yamakawa A, Koshihara Y 1995 Interleukin-4 stimulates pro-alpha 1(VI) collagen gene expression in cultured human osteoblast-like cells. Biochem Biophys Res Commun 211:727-734.
20. Tsai C, Diaz LA Jr, Singer NG, Li LL, Kirsch AH, Mitra R, Nickoloff BJ, Crofford LJ, Fox DA 1996 Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes. Arthritis Rheum 39:125-136.
21. Yamamura Y, Gupta R, Morita Y, He X, Pai R, Endres J, Freiberg A, Chung K, Fox DA 2001 Effector function of resting T cells: Activation of synovial fibroblasts. J Immunol 166:2270-2275.
22. Saifullah MK, Fox DA, Sarkar S, Abidi SM, Endres J, Piktel J, Haqqi TM, Singer NG 2004 Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues. J Immunol 173:6125-6133.
23. Brennan F, Hayes A, Ciesielski C, Green P, Foxwell B, Feldman M 2002 Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor kappa B pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum 46:31-41.
24. Arai F, Ohneda O, Miyamoto T, Zhang XQ, Suda T 2002 Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med 195:1549-1563.
25. Hubbard AK, Rothlein R 2000 Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med 28:1379-1386.
26. Tani-Ishii N, Penninger JM, Matsumoto G, Teranaka T, Umemoto T 2002 The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. J Periodontal Res 37:184-191.
27. Elangbam CS, Quails CW Jr, Dahlgren RR 1997 Cell adhesion molecules-update. Vet Pathol 34:61-73.
28. Sansom DM, Manzotti CN, Zheng Y 2003 What's the difference between CD80 and CD86? Trends Immunol 24:314-319.
29. Bott CM, Doshi JB, Morimoto C, Romain PL, Fox DA 1993 Activation of human T cells through CD6: Functional effects of a novel anti-CD6 monoclonal antibody and definition of four epitopes of the CD6 glycoprotein. Int Immunol 5:783-792.
30. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U 1995 Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med 181:2213-2220.
31. Hassan NJ, Barclay AN, Brown MH 2004 Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol 34:930-940.
32. Mentlein R 1999 Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85:9-24.
33. Dang NH, Morimoto C 2002 CD26: An expanding role in immune regulation and cancer. Histol Histopathol 17:1213-1226.
34. Schiffenbauer J 1999 Superantigens and their role in autoimmune d isorders. Arch Immunol Ther Exp (Warsz) 47:17-24.
35. Rott O, Tonisch U, Fleischer B 1993 Dissociation of antigen-presenting capacity of astrocytes for peptide-antigens versus superantigens. J Immunol 150:87-95.
36. Wong PK, Campbell IK, Egan PJ, Ernst M, Wicks IP 2003 The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis Rheum 48:1177-1189.
37. Smeets TJ, Barg EC, Kraan MC, Smith MD, Breedveld FC, Tak PP 2003 Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: Comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis. Ann Rheum Dis 62:635-638.
38. Rifas L, Avioli LV 1999 A novel T cell cytokine stimulates interleukin-6 in human osteoblastic cells. J Bone Miner Res 14:1096-1103.
39. Schrum LW, Marriott I, Butler BR, Thomas EK, Hudson MC, Bost KL 2003 Functional CD40 expression induced following bacterial infection of mouse and human osteoblasts. Infect Immun 71:1209-1216.
40. Witowski J, Ksiazek K, Jorres A 2004 Interleukin-17: A mediator of inflammatory responses. Cell Mol Life Sci 61:567-579.
41. Van bezooijen RL, Farih-Sips HC, Papapoulos SE, Lowik CW 1999 Interleukin-17: A new bone acting cytokine in vitro. J Bone Miner Res 14:1513-1521.
42. Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL 2004 Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem 279:2559-2567.
43. Tokuda H, Kozawa O, Uematsu T 2002 Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts. Prostaglandins Leukot Essent Fatty Acids 66:427-433.