Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice

Hypertension

Volumn 60, Issue 5, 2012, Pages 1207-1212

  Chan, Christopher T ^a   Moore, Jeffrey P ^a   Budzyn, Klaudia ^a   Guida, Elizabeth ^a   Diep, Henry ^a   Vinh, Antony ^a   Jones, Emma S ^a   Widdop, Robert E ^a   Armitage, James A ^a   Sakkal, Samy ^a   Ricardo, Sharon D ^a   Sobey, Christopher G ^a   Drummond, Grant R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

CCR2 antagonist; chemokine receptors; hypertension; macrophages

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; DEOXYCORTICOSTERONE ACETATE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 5; N [2 [[1 [4 (1,3 BENZODIOXOL 5 YL) 4 HYDROXYCYCLOHEXYL] 4 ETHOXY 3 PYRROLIDINYL]AMINO] 2 OXOETHYL] 3 (TRIFLUOROMETHYL)BENZAMIDE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; CELL INFILTRATION; CELL TRANSPORT; CONTROLLED STUDY; FLOW CYTOMETRY; HYPERTENSION; LEUKOCYTE; MACROPHAGE; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SHAM PROCEDURE; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

ANIMALS; AORTA; BLOOD PRESSURE; CHEMOKINE CCL2; CHEMOKINE CCL7; CHEMOKINE CCL8; DESOXYCORTICOSTERONE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HYPERTENSION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MONOCYTE CHEMOATTRACTANT PROTEINS; PYRROLIDINES; RECEPTORS, CCR2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM CHLORIDE; UP-REGULATION;

EID: 84868207584     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.201251     Document Type: Article

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