Spinal Cord Injury

Handbook of Stem Cells

Volumn 1, Issue , 2004, Pages 701-712

  McDonald, John W ^a,b   Becker, Daniel ^c   Huettner, James ^b  

^a Neurological Surgery and Anatomy and Neurobiology   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84868153760     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012436643-5/50078-X     Document Type: Chapter

References (76)

1. National Spinal Cord Injury Database Spinal Cord Injury: Facts and Figures, May 2001 2001.
2. McDonald J.W., Sadowsky C. Spinal-cord injury. Lancet 2002, 359:417-425.
3. McKinley W.O., Jackson A.B., Cardenas D.D., DeVivo M.J. Long-term medical complications after traumatic spinal cord injury: a regional model systems analysis. Arch. Phys. Med. Rehab. 1999, 80:1402-1410.
4. Sjolund B.H. Pain and rehabilitation after spinal cord injury: the case of sensory spasticity?. Brain Res. Brain Res. Rev. 2002, 40:250-256.
5. Auld D.S., Robitaille R. Perisynaptic Schwann cells at the neuromuscular junction: nerve- and activity-dependent contributions to synaptic efficacy, plasticity, and reinnervation. Neuroscientist 2003, 9:144-157.
6. Rossi S.G., Dickerson I.M., Rotundo R.L. Localization of the calcitonin gene-related peptide receptor complex at the vertebrate neuromuscular junction and its role in regulating acetylcholinesterase expression. J. Biol. Chem. 2003, 278:24,994-25,000.
7. Burke R.E. The central pattern generator for locomotion in mammals. Adv. Neurol. 2001, 87:11-24.
8. Dietz V. Central pattern generator. Paraplegia 1995, 33:739.
9. Barbeau H., McCrea D.A., O'Donovan M.J., Rossignol S., Grill W.M., Lemay M.A. Tapping into spinal circuits to restore motor function. Brain Res. Brain Res. Rev. 1999, 30:27-51.
10. Crowe M.J., Bresnahan J.C., Shuman S.L., Masters J.N., Beattie M.S. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat. Med. 1997, 3:73-76.
11. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., Gage F.H. Neurogenesis in the adult human hippocampus. Nat. Med. 1998, 4:1313-1317.
12. Winner B., Cooper-Kuhn C.M., Aigner R., Winkler J., Kuhn H.G. Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb. Eur. J. Neurosci. 2002, 16:1681-1689.
13. Herndon R.M., Price D.L., Weiner L.P. Regeneration of oligodendroglia during recovery from demyelinating disease. Science 1977, 195:693-694.
14. Ludwin S.K. Proliferation of mature oligodendrocytes after trauma to the central nervous system. Nature 1984, 308:274-275.
15. Weidner N., Ner A., Salimi N., Tuszynski M.H. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:3513-3518.
16. Horner P.J., Power A.E., Kempermann G., Kuhn H.G., Palmer T.D., Winkler J., Thal L.J., Gage F.H. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J. Neurosci. 2000, 20:2218-2228.
17. Becker D., Grill W.M., McDonald J.W. Functional Electrical Stimulation Helps Replenish Neural Cells in the Adult CNS After Spinal Cord Injury. the 55th annual meeting of the American Academy of Neurology 2003, Paper presented at.
18. Tuszynski M.H., Grill R., Jones L.L., McKay H.M., Blesch A. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J. Comp. Neurol. 2002, 449:88-101.
19. Prewitt C.M., Niesman I.R., Kane C.J., Houle J.D. Activated macrophage-microglial cells can promote the regeneration of sensory axons into the injured spinal cord. Exp. Neurol. 1997, 148:433-443.
20. Morgenstern D.A., Asher R.A., Fawcett J.W. Chondroitin sulphate proteoglycans in the CNS injury response. Prog. Brain Res. 2002, 137:313-332.
21. Blight A.R. Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line sampling. Neuroscience 1983, 10:521-543.
22. Nashmi R., Fehlings M.G. Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels. Brain Res. Brain Res. Rev. 2001, 38:165-191.
23. Novikova L.N., Novikov L.N., Kellerth J.O. Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats. J. Comp. Neurol. 2002, 452:255-263.
24. Tatagiba M., Brosamle C., Schwab M.E. Regeneration of injured axons in the adult mammalian central nervous system. Neurosurgery 1997, 40:541-546.
25. Bregman B.S., Coumans J.V., Dai H.N., Kuhn P.L., Lynskey J., McAtee M., Sandhu F. Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. Prog. Brain Res. 2002, 137:257-273.
26. Murray M., Kim D., Liu Y., Tobias C., Tessler A., Fischer I. Transplantation of genetically modified cells contributes to repair and recovery from spinal injury. Brain Res. Brain Res. Rev. 2002, 40:292-300.
27. Dickson J.G., Kesselring J., Walsh F.S., Davison A.N. Cellular distribution of 04 antigen and galactocerebroside in primary cultures of human fetal spinal cord. Acta. Neuropathol. (Berl.) 1985, 68:340-344.
28. Satoh J., Kim S.U. Proliferation and differentiation of fetal human oligodendrocytes in culture. J. Neurosci. Res. 1994, 39:260-272.
29. Gamble H.J. Electron microscope observations on the human fetal and embryonic spinal cord. J. Anat. 1969, 104:435-453.
30. Weidenheim K.M., Kress Y., Epshteyn I., Rashbaum W.K., Lyman W.D. Early myelination in the human fetal lumbosacral spinal cord: characterization by light and electron microscopy. J. Neuropathol. Exp. Neurol. 1992, 51:142-149.
31. Benes F.M., Turtle M., Khan Y., Farol P. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch. Gen. Psychi. 1994, 51:477-484.
32. Poduslo S.E., Jang Y. Myelin development in infant brain. Neurochem. Res. 1984, 9:1615-1626.
33. Barres B.A., Raff M.C. Axonal control of oligodendrocyte development. Glia Cell Development: Basic Principles and Clinical Relevance 1996, 71-83. Bios Scientific, Cambridge. K.R. Jessen (Ed.).
34. Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., Jessell T.M. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 1995, 81:445-455.
35. Hajihosseini M., Tham T.N., Dubois-Dalcq M. Origin of oligodendrocytes within the human spinal cord. J. Neurosci. 1996, 16:7981-7994.
36. Dubois-Dalcq M., Murray K. Why are growth factors important in oligodendrocyte physiology?. Pathol. Biol. (Paris) 2000, 48:80-86.
37. Jessell T.M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genet. 2000, 1:20-29.
38. Munoz-Sanjuan I., Brivanlou A.H. Neural induction, the default model, and embryonic stem cells. Nat. Rev. Neurosci. 2002, 3:271-280.
39. Durston A.J., van der W.J., Pijnappel W.W., Godsave S.F. Retinoids and related signals in early development of the vertebrate central nervous system. Curr. Top. Dev. Biol. 1998, 40:111-175.
40. Briscoe J., Ericson J. Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 2001, 11:43-49.
41. Renoncourt Y., Carroll P., Filippi P., Arce V., Alonso S. Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons. Mech. Dev. 1998, 79:185-197.
42. Wichterle H., Lieberam I., Porter J.A., Jessell T.M. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002, 110:385-397.
43. Sotomaru Y., Kato Y., Tsunoda Y. Induction of pluripotency by injection of mouse trophectoderm cell nuclei into blastocysts following transplantation into enucleated oocytes. Theriogenology 1999, 52:213-220.
44. Kaufman M.H., Robertson E.J., Handyside A.H., Evans M.J. Establishment of pluripotential cell lines from haploid mouse embryos. J. Embryol. Exp. Morphol. 1983, 73:249-261.
45. Aguayo A.J., David S., Bray G.M. Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J. Exp. Biol. 1981, 95:231-240.
46. Bunge M.B. Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants. Prog. Brain Res. 2002, 137:275-282.
47. Hains B.C., Johnson K.M., Eaton M.J., Willis W.D., Hulsebosch C.E. Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat. Neuroscience 2003, 116:1097-1110.
48. Jiang S., Wang J., Khan M.I., Middlemiss P.J., Salgado-Ceballos H., Werstiuk E.S., Wickson R., Rathbone M.P. Enteric glia promote regeneration of transected dorsal root axons into spinal cord of adult rats. Exp. Neurol. 2003, 181:79-83.
49. Akiyama Y., Radtke C., Honmou O., Kocsis J.D. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 2002, 39:229-236.
50. Cao Q., Benton R.L., Whittemore S.R. Stem cell repair of central nervous system injury. J. Neurosci. Res. 2002, 68:501-510.
51. Kennea N.L., Mehmet H. Neural stem cells. J. Pathol. 2002, 197:536-550.
52. Liu Y., Rao M.S. Transdifferentiation: fact or artifact. J. Cell Biochem. 2003, 88:29-40.
53. Gottlieb D.I., Huettner J.E. An in vitro pathway from embryonic stem cells to neurons and glia. Cells Tissue Organs 1999, 165:165-172.
54. Brustle O., Jones K.N., Learish R.D., Karram K., Choudhary K., Wiestler O.D., Duncan I.D., McKay R.D. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 1999, 285:754-756.
55. McKay R. Stem cells in the central nervous system. Science 1997, 276:66-71.
56. McDonald J.W., Liu X.Z., Qu Y., Liu S., Mickey S.K., Turetsky D., Gottlieb D.I., Choi D.W. Transplanted embryonic stem cells survive, differentiate, and promote recovery in injured rat spinal cord. Nat. Med. 1999, 5:1410-1412.
57. Liu S., Qu Y., Stewart T.J., Howard M.J., Chakrabortty S., Holekamp T.F., McDonald J.W. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:6126-6131.
58. Strubing C., Ahnert-Hilger G., Shan J., Wiedenmann B., Hescheler J., Wobus A.M. Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech. Dev. 1995, 53:275-287.
59. Finley M.F., Kulkarni N., Huettner J.E. Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells. J. Neurosci. 1996, 16:1056-1065.
60. Okabe S., Forsberg-Nilsson K., Spiro A.C., Segal M., McKay R.D. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech. Dev. 1996, 59:89-102.
61. Bulte J.W., Douglas T., Witwer B., Zhang S.C., Strable E., Lewis B.K., Zywicke H., Miller B., van Gelderen P., Moskowitz B.M., Duncan I.D., Frank J.A. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat. Biotechnol. 2001, 19:1141-1147.
62. Lu J., Bulte J.W., Liu S., Schottler F., Howard M.J., Zywicke H., van Gelderen P., Douglas T., Frank J.A., McDonald J.W. MR Imaging of Transplanted Labeled Embryonic Stem (ES) Cells in the Contusion Injured Spinal Cord. the 31st annual meeting of the Society for Neuroscience 2003, Paper presented at.
63. Ao H., Qu Y., McDonald J.W. Intrathecal ES cell transplantation: self-organization into CNS-like tissue with features resembling normal spinal cord. Nat. Biotechnol. 2003, Society for Neuroscience (abstract).
64. Cao Q.L., Howard R.M., Dennison J.B., Whittemore S.R. Differentiation of engrafted neuronal-restricted precursor cells in inhibited in the traumatically injured spinal cord. Exp. Neurol. 2002, 177:349-359.
65. Murray M., Fischer I. Transplantation and gene therapy: Combined approaches for repair of spinal cord injury. Neuroscientist 2001, 7:28-41.
66. Vadivelu S., Stewart T.J., Miller J.H., Tom V., Liu S., Li Q., Howard M.J., Silver J., McDonald J.W. Embryonic Stem Cell Transplantation: Penetration of the Glial Scar and Robust Axonal Regeneration into White Matter in the Injured Adult Rat Spinal Cord. the 33rd annual meeting of the Society for Neuroscience 2003, Paper to be presented at.
67. Mouveroux J.M., Verkijk M., Lakke E.A., Marani E. Intrinsic properties of the developing motor cortex in the rat: In vitro axons from the medial somatomotor cortex grow faster than axons from the lateral somatomotor cortex. Brain Res. Dev. Brain Res. 2000, 122:59-66.
68. Teng Y.D., Lavik E.B., Qu X., Park K.I., Ourednik J., Zurakowski D., Langer R., Snyder E.Y. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:3024-3029.
69. Rossignol S., Chau C., Brustein E., Giroux N., Bouyer L., Barbeau H., Reader T.A. Pharmacological activation and modulation of the central pattern generator for locomotion in the cat. Ann. NY Acad. Sci. 1998, 860:346-359.
70. Ankeny D.P., McTigue D.M., Guan Z., Yan Q., Kinstler O., Stokes B.T., Jakeman L.B. Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury. Exp. Neurol. 2001, 170:85-100.
71. Tada M., Takahama Y., Abe K., Nakatsuji N., Tada T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol. 2001, 11:1553-1558.
72. McDonald, J.W. (Unpublished observations).
73. Lockman P.R., Mumper R.J., Khan M.A., Allen D.D. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 2002, 28:1-13.
74. Ma Y., Feigin A., Dhawan V., Fukuda M., Shi Q., Greene P., Breeze R., Fahn S., Freed C., Eidelberg D. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann. Neurol. 2002, 52:628-634.
75. Hubner K., Fuhrmann G., Christenson L.K., Kehler J., Reinbold R., De La Fuente R., Wood J., Strauss J.F., Boiani M., Scholer H.R. Derivation of oocytes from mouse embryonic stem cells. Science 2003, 300:1251-1256.
76. Becker D., Sadowsky C.L., McDonald J.W. Restoring function after spinal cord injury. Neurologist. 2003, 9(1):1-15.