In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 10, 2004, Pages 1572-1575

  Tsutsumi, Hiroe ^a   Katagi, Munehiro ^a   Nishikawa, Mayumi ^a   Tsuchihashi, Hitoshi ^a   Kasuya, Fumiyo ^b   Igarashi, Kazuo ^b  

^a Chuo ward   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Flavin containing monooxygenase (FMO); N oxidation; Selegiline

Indexed keywords

CYTOCHROME P450 INHIBITOR; DIMETHYLANILINE MONOOXYGENASE; DRUG METABOLITE; ENZYME ACTIVATOR; OCTYLAMINE; OXYGENASE INHIBITOR; PROADIFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELEGILINE; SELEGILINE N OXIDE; THIAMAZOLE; UNCLASSIFIED DRUG; AMINE; ANTIPARKINSON AGENT; DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING); DRUG DERIVATIVE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGENASE; SELEGILINE-N-OXIDE;

ANIMAL TISSUE; ARTICLE; DRUG OXIDATION; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; NONHUMAN; PARKINSON DISEASE; PH; RAT; ANIMAL; ENZYMOLOGY; HEATING; LIVER MICROSOME; METABOLISM; OXIDATION REDUCTION REACTION;

AMINES; ANIMALS; ANTIPARKINSON AGENTS; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; HEATING; HYDROGEN-ION CONCENTRATION; METHIMAZOLE; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; OXYGENASES; PROADIFEN; RATS; SELEGILINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 21644447392     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.1572     Document Type: Article

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