Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup

Acta Gastro-Enterologica Belgica

Volumn 73, Issue 1, 2010, Pages 12-17

  Yamada, Tamaki ^a   Suzuki, Sadao ^b   Fukatsu, Mitsuru ^a   Wada, Tsuneya ^a   Yoshida, Takashi ^a   Joh, Takashi ^c  

^a Okazaki City Medical Association   (Japan)

^b Department of Public Health ^*  (Australia)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Health checkup; Nonalcoholic fatty liver disease; Risk factor; Uric acid

Indexed keywords

GLUCOSE; TRIACYLGLYCEROL; URIC ACID;

ADULT; ARTICLE; BODY MASS; ECHOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; JAPANESE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PATHOGENESIS; PREVALENCE; QUESTIONNAIRE; RETROSPECTIVE STUDY; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; ASIAN; BLOOD; DRINKING BEHAVIOR; FATTY LIVER; JAPAN; MIDDLE AGED; PHYSICAL EXAMINATION; SEX DIFFERENCE; STATISTICS;

ADULT; ALCOHOL DRINKING; ASIAN CONTINENTAL ANCESTRY GROUP; FATTY LIVER; FEMALE; HUMANS; JAPAN; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PHYSICAL EXAMINATION; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; URIC ACID;

EID: 77954921930     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. ANGELICO F., DEL BEN M., CONTI R., FRANCIOSO S., FEOLE K., MACCIONI D., ANTONINI T.M., ALESSANDRI C. Non-alcoholic fatty liver syndrome : a hepatic consequence of common metabolic diseases. J. Gastroenterol. Hepatol., 2003, 18 : 588-594.
2. VERRIJKEN A., FRANCQUE S., VAN GAAL L. The metabolic syndrome and the liver. Acta Gastroenterol. Belg., 2008, 71 : 48-59.
3. JIMBA S., NAKAGAMI T., TAKAHASHI M., WAKAMATSU T., HIROTA Y., IWAMOTO Y., WASADA T. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet. Med., 2005, 22 : 1141-1145.
4. KIM C.H., PARK K.U., LEE K.U., KIM J.H., KIM H.K. Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults. Diabet. Med., 2008, 25 : 476-481.
5. YAMADA T., FUKATSU M., SUZUKI S., YOSHIDA T., TOKUDOME S., JOH T. Alcohol drinking may not be a major risk factor for fatty liver in Japanese undergoing a health checkup. Dig. Dis. Sci., 2010, 55 : 176-182.
6. TARGHER G. Nonalcoholic fatty liver disease, the metabolic syndrome. Diabet. Med., 2007, 24 : 1-6.
7. HAMAGUCHI M., KOJIMA T., TAKEDA N., NAKAGAWA T., TANIGUCHI H., FUJII K., OMATSU T., NAKAJIMA T., SARUI H., SHIMAZAKI M., KATO T., OKUDA J., IDA K. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann. Intern. Med., 2005, 143 : 722-728.
8. FRIIS-LIBY I., ALDENBORG F., JERLSTAD P., RUNDSTROM K., BJORSSON E. High prevalence of metabolic complications in patients with nonalcoholic fatty liver disease. Scand. J. Gastroenterol., 2004, 39 : 864-869.
9. KONTRONEN A., YKI-JARVINEN H. Fatty liver : a novel component of the metabolic syndrome. Arterioscler. Thromb. Vasc. Biol., 2008, 28 : 27-38.
10. TANIGUCHI Y., HAYASHI T., TAMURA K., ENDO G., FUJII S., OKADA K. Serum uric acid and the risk of Type 2 diabetes in Japanese men : Osaka Health Survey. J. Hypertens, 2001, 19 : 1209-1215.
11. HIKITA M., OHNO I., MORI Y., ICHIDA K., YOKOSE T., HOSOYA T. Relationship between hyperuricemia and body fat distribution. Intern. Med., 2007, 46 : 1353-1358.
12. KAWAMOTO R., TOMITA H., OKA Y., OHTSUKA N. Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclerosis . Intern. Med., 2006, 45 : 605-614.
13. TSOULI S.G., LIBEROPOULOS E.N., MIKHAILIDIS D.P., ATHYROS V.G., ELISAF M.S. Elevated serum uric acid levels in metabolic syndrome : an active component or innocent bystander ? Metabolism, 2006, 55 : 1293-1301.
14. KANG Y.H., MIN H.G., KIM I.J., KIM Y.K., SON S.M. Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults. Endocrine J., 2008, 55 : 1093-1102.
15. CONEN D., WIETLISBACH V., BOVET P., SHAMLAYE C., RIESEN W., PACCAUD F., BURNIER M. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in developing country. BMC. Public Health, 2004, 4 : 1-9.
16. BABA T., AMASAKI Y., SODA M., HIDA A., IMAIZUMI M., ICHIMARU S., NAKASHIMA E., SATO S., YANO K., AKAHOSHI M. Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki. Hypertens. Res., 2007, 30 : 823-830.
17. TAKAHASHI S., MORIWAKI Y., TSUTSUMI Z., YAMAKITA J., TAMAMOTO T., HADA T. Increased visceral fat accumulation further aggravates the risks of insulin resistance in gout. Metabolism, 2001, 50 : 393-398.
18. LEE S., JIN KIM Y., YONG JEON T., HOI KIM H., WOO OH S., PARK Y., SOO KIM S. Obesity is the only independent factor associated with ultrasound- diagnosed non-alcoholic fatty liver disease : a cross-sectional casecontrol study. Scand. J. Gastroenterol., 2006, 41 : 566-572.
19. LONARDO A., LORIA P., LEONARDI F., BORSATTI A., NERI P., PULVIRENTI M., VERRONE A.M., BAGNI A., BERTOLOTTI M., GANAZZI D., CARULLI N. ; POLI. ST.E.N.A. Study Group. Policentrica Steatosi Epatica Non Alcolica. Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. Dig. Liver Dis., 2002, 32 : 204-211.
20. LI Y., XU C., YU C., XU L., MIAO M. Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. J. Hepatol., 2009, 50 : 1029-1034.
21. OMAGARI K., KADOKAWA Y., MASUDA J., EGAWA I., SAWA T., HAZAMA H., OHBA K., ISOMOTO H., MIZUTA Y., HAYASHIDA K., MURASE K., KADOTA T., MURATA I., KOHNO S. Fatty liver in non-alcoholic non-overweight Japanese adults : Incidence and clinical characteristics. J. Gastroenterol. Hepatol., 2002, 17 : 1098-1105.
22. SARTORIO A., DEL COL A., AGOSTI F., MAZZILLI G., BELLENTANI S., TIRIBELLI C., BEDOGNI G. Predictors of non-alcoholic fatty liver disease in obese children. Eur. J. Clin. Nutr., 2007, 61 : 877-883.
23. SAKUGAWA H., NAKAYOSHI T., KOBASHIGAWA K., NAKASONE H., KAWAKAMI Y., YAMASHIRO T., MAESHIRO T., TOMIMORI K., MIYAGI S., KINJO F., SAITO A. Metabolic syndrome is directly associated with gamma glutamyl transpeptidase elevation in Japanese women. World J. Gastroenterol, 2004, 10 : 1052-1055.
24. SAVERYMUTTU S.H., JOSEPH A.E., MAXWELL J.D. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br. Med. J., 1986, 292 : 13-15.
25. OSAWA H., MORI Y. Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical echo amplitudes. J. Clin. Ultrasound, 1996, 24 : 25-29.
26. MELLEN P.B., BLEYER A.J., ERLINGER T.P., EVANS G.W., NIETO F.J., WAGENKNECHT L.E., WOFFORD M.R., HERRINGTON D.M. Serum uric acid predicts hypertension in a biethnic cohort : the atherosclerosis risk in communities study. Hypertension, 2006, 48 : 1037-1042.
27. BOS M.J., KOUDSTAAL P.J., HOFMAN A., WITTEMAN J.C.M., BRETELER M.M.B. Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. Stroke, 2006, 37 : 1503-1507. (Pubitemid 44305733)
28. CHIEN K.L., CHEN M.F., HSU H.C., CHANG W.T., SU T.C., LEE Y.T., HU F.B. Plasma uric acid and the risk for type 2 diabetes in a Chinese community. Clinical Chemistry, 2008, 54 : 310-316.
29. CIRILLO P., SATO W., REUNGJUI S., HEINIG M., GERSCH M., SAUTIN Y., NAKAGAWA T., JOHNSON R.J. Uric acid, the metabolic syndrome, and renal disease. J. Am. Soc. Nephrol., 2006, 17 : S165-S168.
30. MUSCELLI E., NATALI A., BIANCHI S., BIGAZZI R., GALVAN A.Q., SIRONI A.M., FRASCERRA S., CIOCIARO D., FERRANNINI E. Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am. J. Hypertens., 1996, 9 : 746-752.
31. QUINONES GALAVAN A., NATALI A., BALDI S., FRASCERRA S., SANNA G., CIOCIARO D., FERRANNINI E. Effect of insulin on uric acid excretion in human. Am. J. Physiol., 1995, 268 : E1-E5.
32. NAKAGAWA T., HU H., ZARIKOV S., TUTTLE K.R., SHORT R.A., GLUSHAKOVA O., OUYANG X., FEIG D.I., BLOCK E.R., HERRERAACOSTA J., PATEL J.M., JOHNSON R.J. A causal role for uric acid in fructose- induced metabolic syndrome. Am. J. Physiol., 2006, 209 : R625-R631.
33. KHOSLA U.M., ZHARIKOV S., FINCH J.L., NAKAGAWA T., RONCAL C., MU W, KROTOVA K., BLOCK E.R., PRABHAKAR S., JOHNSON R.J. Hyperuricemia induces endothelial dysfunction. Kidney Int., 2005, 67 : 1739-1742.
34. ROY D., PERREAULT M., MARETTE A. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent. Am. J. Physiol., 1998, 274 : E692-E699.
35. NIETO F.J., IRIBARREN C., GROSS M.D., COMSTOCK G.W., CUTLER R.G. Uric acid and serum antioxidant capacity : a reaction to atherosclerosis ? Atherosclerosis, 2000, 148 : 131-139.
36. VOURINEN-MARKKOLA H., YKI-JARVINEN H. Hyperuricemia and insulin resistance. J. Clin. Endocrinol. Metab., 1994, 78 : 25-29.
37. MATSUURA F., YAMASHITA S., NAKAMURA T., NISHIDA M., NOZAKI S., FUNAHASHI T., MATSUZAWA Y. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects : visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism, 1998, 93 : 929-933.
38. SEPPALA-LINDROOS A., VEHKAVAARA S., HAKKINEN A.M., GOTO T., WESTERBACKA J., SOVIJARVI A., HALAVAARA J., YKIJARVINEN H. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab., 2002, 87 : 3023-3028.
39. ADIELS M., TASKINEN M.R., PACKARD C., CASLAKE M.J., SOROPAAVONEN A., WESTERBACKA J., VEHKAVAARA S., HAKKINEN A., OLOFSSON S.O., YKI-JARVINEN H., BOREN J. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia, 1997, 40 : 454-462.
40. DIXON J.B., BHATHAL P.S., O'BRIEN P.E. Nonalcoholic fatty liver disease : predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology, 2001, 121 : 91-100.
41. MCCULLOUGH A.J. Update on nonalcoholic fatty liver disease. J. Clin. Gastroenterology, 2002, 35 : 255-262.
42. LIN Y.-U., LO H.-M., CHEN J.-D. Sonographic fatty liver, overweight and ischemic disease. World J. Gastroenterol., 2005, 11 : 4838-4842