Copper(II)-fluoroquinolone complexes with anti- Trypanosoma cruzi activity and DNA binding ability

BioMetals

Volumn 25, Issue 5, 2012, Pages 951-960

  Martins, Darliane A ^a   Gouvea, Ligiane R ^a   Da Gama Jean Batista, Denise ^b   Da Silva, Patrícia Bernardino ^b   Louro, Sonia R W ^c   De Nazaré C Soeiro, Maria ^b   Teixeira, Letícia R ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Anti T. cruzi activity; Copper(II)complexes; Fluoroquinolones; Interaction with calf thymus DNA; UV Vis spectroscopy

Indexed keywords

BENZNIDAZOLE; CARBOXYLIC ACID; COPPER; COPPER CHLORIDE; DNA; KETONE; LEVOFLOXACIN; LIGAND; OXYGEN; QUINOLONE DERIVATIVE; SPARFLOXACIN;

ARTICLE; CHAGAS DISEASE; DNA BINDING; DRUG ACTIVITY; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; IC 50; IN VITRO STUDY; NONHUMAN; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CATTLE; COPPER; DNA; ELECTRON SPIN RESONANCE SPECTROSCOPY; FLUOROQUINOLONES; OFLOXACIN; ORGANOMETALLIC COMPOUNDS; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84868145940     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9565-3     Document Type: Article

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