메뉴 건너뛰기




Volumn 137, Issue 2, 2010, Pages 251-259

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi

Author keywords

Aromatic diamidines; Chagas disease; Chemotherapy; Trypanosoma cruzi

Indexed keywords

ANTITRYPANOSOMAL AGENT; AROMATIC COMPOUND; DB 1582; DB 1627; DB 1645; DB 1646; DB 1651; DB 1670; DIAMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 77949659324     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182009991223     Document Type: Article
Times cited : (28)

References (44)
  • 1
    • 33750507750 scopus 로고    scopus 로고
    • Targeting of toxic compounds to the trypanosome's interior
    • doi:10.1016/ S0065-308X(06)63002-63009
    • Barrett, M. P. and Gilbert, I. H. (2006). Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology 63, 125-133. doi:10.1016/ S0065-308X(06)63002-63009
    • (2006) Advances in Parasitology , vol.63 , pp. 125-133
    • Barrett, M.P.1    Gilbert, I.H.2
  • 2
    • 0038742717 scopus 로고    scopus 로고
    • Pentamidine uptake and resistance in pathogenic protozoa: Past, present and future
    • doi:10.1016/S1471-4922(03)00069-2
    • Bray, P. G., Barrett, M. P., Ward, S. A. and de Koning, H. P. (2003). Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology 19, 232-239. doi:10.1016/S1471-4922(03)00069-2.
    • (2003) Trends in Parasitology , vol.19 , pp. 232-239
    • Bray, P.G.1    Barrett, M.P.2    Ward, S.A.3    De Koning, H.P.4
  • 3
    • 0028875686 scopus 로고
    • Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei
    • Carter, N. S., Berger, B. J. and Fairlamb, A. H. (1995). Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei. The Journal of Biological Chemistry 270, 28153-28157.
    • (1995) The Journal of Biological Chemistry , vol.270 , pp. 28153-28157
    • Carter, N.S.1    Berger, B.J.2    Fairlamb, A.H.3
  • 4
    • 0002921521 scopus 로고
    • Nova tripanossomíase humana: Estudos sobre a morfologia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., agente etiológico de nova entidade mórbida do homem
    • Chagas, C. (1909). Nova tripanossomíase humana: Estudos sobre a morfologia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., agente etiológico de nova entidade mórbida do homem. Memórias do Instituto Oswaldo Cruz 1, 159-218.
    • (1909) Memórias Do Instituto Oswaldo Cruz , vol.1 , pp. 159-218
    • Chagas, C.1
  • 6
    • 0036359943 scopus 로고    scopus 로고
    • A critical review on Chagas disease chemotherapy
    • doi: 10.1590/S0074-02762002000100001
    • Coura, J. R. and De Castro, S. L. (2002). A critical review on Chagas disease chemotherapy. Memórias do Instituto Oswaldo Cruz 97, 3-24. doi: 10.1590/S0074-02762002000100001.
    • (2002) Memórias Do Instituto Oswaldo Cruz , vol.97 , pp. 3-24
    • Coura, J.R.1    De Castro, S.L.2
  • 7
    • 33745058473 scopus 로고    scopus 로고
    • Induction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicry
    • doi: 10.1080/08916930500485002
    • Cunha-Neto, E., Bilate, A. M., Hyland, K. V., Fonseca, S. G., Kalil, J. and Engman, D. M. (2006). Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity 39, 41-54. doi: 10.1080/08916930500485002.
    • (2006) Autoimmunity , vol.39 , pp. 41-54
    • Cunha-Neto, E.1    Bilate, A.M.2    Hyland, K.V.3    Fonseca, S.G.4    Kalil, J.5    Engman, D.M.6
  • 8
    • 2442657704 scopus 로고    scopus 로고
    • Biological and ultrastructural effects of the anti-microtubule agent taxol against Trypanosoma cruzi
    • Dantas, A. P., Barbosa, H. S. and De Castro, S. L. (2003). Biological and ultrastructural effects of the anti-microtubule agent taxol against Trypanosoma cruzi. Journal of Submicroscopic Cytology and Pathology 35, 287-294.
    • (2003) Journal of Submicroscopic Cytology and Pathology , vol.35 , pp. 287-294
    • Dantas, A.P.1    Barbosa, H.S.2    De Castro, S.L.3
  • 9
    • 0035119571 scopus 로고    scopus 로고
    • Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: Implications for cross-resistance with arsenicals
    • de Koning, H. P. (2001). Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Molecular Pharmacology 59, 586-592.
    • (2001) Molecular Pharmacology , vol.59 , pp. 586-592
    • De Koning, H.P.1
  • 10
    • 3242723129 scopus 로고    scopus 로고
    • Phenyl substitution of furamidine markedly potentiates its antiparasitic activity against Trypanosoma cruzi and Leishmania amazonensis
    • doi:10.1016/ j.bcp.2004.04.019
    • De Souza, E. M., Lansiaux, A., Bailly, C., Wilson, W. D., Hu, Q., Boykin, D. W., Batista, M. M., Araú jo-Jorge, T. C. and Soeiro, M. N. (2004). Phenyl substitution of furamidine markedly potentiates its antiparasitic activity against Trypanosoma cruzi and Leishmania amazonensis. Biochemical Pharmacology 68, 593-600. doi:10.1016/ j.bcp.2004.04.019.
    • (2004) Biochemical Pharmacology , vol.68 , pp. 593-600
    • De Souza, E.M.1    Lansiaux, A.2    Bailly, C.3    Wilson, W.D.4    Hu, Q.5    Boykin, D.W.6    Batista, M.M.7    Araújo-Jorge, T.C.8    Soeiro, M.N.9
  • 11
    • 33747893718 scopus 로고    scopus 로고
    • Trypanocidal activity of the phenyl-substituted analogue of fumidine DB569 against Trypanosoma cruzi infection in vivo
    • doi:10.1093/jac/dkl259
    • De Souza, E. M., Oliveira, G. M., Boykin, D. W., Kumar, A., Hu, Q. and Soeiro, M. N. C. (2006). Trypanocidal activity of the phenyl-substituted analogue of fumidine DB569 against Trypanosoma cruzi infection in vivo. Journal of Antimicrobial Chemotherapy 58, 610-614. doi:10.1093/jac/dkl259.
    • (2006) Journal of Antimicrobial Chemotherapy , vol.58 , pp. 610-614
    • De Souza, E.M.1    Oliveira, G.M.2    Boykin, D.W.3    Kumar, A.4    Hu, Q.5    Soeiro, M.N.C.6
  • 12
    • 50949127533 scopus 로고    scopus 로고
    • Electrocardiographic finding in acutely and chronically Trypanosoma cruzi-infected mice treated by a phenyl-substituted analogue of Furamidine DB569
    • De Souza, E. M., Oliveira, G. M. and Soeiro, M. N. C. (2007). Electrocardiographic finding in acutely and chronically Trypanosoma cruzi-infected mice treated by a phenyl-substituted analogue of Furamidine DB569. Drug Target Insight 2, 61-69.
    • (2007) Drug Target Insight , vol.2 , pp. 61-69
    • De Souza, E.M.1    Oliveira, G.M.2    Soeiro, M.N.C.3
  • 13
    • 44349096685 scopus 로고    scopus 로고
    • An introduction to the structural organization of parasitic protozoa
    • de Souza, W. (2008). An introduction to the structural organization of parasitic protozoa. Current Pharmaceutical Design 14, 822-838.
    • (2008) Current Pharmaceutical Design , vol.14 , pp. 822-838
    • De Souza, W.1
  • 14
    • 36349010326 scopus 로고    scopus 로고
    • Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusion Chagas disease: Historical aspects, present situation, and perspectives
    • doi: 10.1590/S0074-02762007005000092
    • Dias, J. C. (2007). Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusion Chagas disease: historical aspects, present situation, and perspectives. Memórias do Instituto Oswaldo Cruz 102, 11-18. doi: 10.1590/S0074- 02762007005000092.
    • (2007) Memórias Do Instituto Oswaldo Cruz , vol.102 , pp. 11-18
    • Dias, J.C.1
  • 15
    • 0028979316 scopus 로고
    • Intracellular Ca2+ storage in acidocalcisomes of Trypanosoma cruzi
    • Docampo, R., Scott, D. A., Vercesi, A. E. and Moreno, S. N. (1995). Intracellular Ca2+ storage in acidocalcisomes of Trypanosoma cruzi. The Biochemical Journal 310, 1005-1012.
    • (1995) The Biochemical Journal , vol.310 , pp. 1005-1012
    • Docampo, R.1    Scott, D.A.2    Vercesi, A.E.3    Moreno, S.N.4
  • 16
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas Disease
    • Filardi, L. S. and Brener, Z. (1987). Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas Disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 755-759.
    • (1987) Transactions of the Royal Society of Tropical Medicine and Hygiene , vol.81 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 18
  • 19
    • 0642281742 scopus 로고    scopus 로고
    • Pathophysiology of the heart in Chagas' disease: Current status and new developments
    • doi:10.1016/S0008-6363(03)00361-4
    • Higuchi, M. L., Benvenuti, L. A., Martins Reis, M. and Metzger, M. (2003). Pathophysiology of the heart in Chagas' disease: current status and new developments. Cardiovascular Research 60, 96-107. doi:10.1016/S0008-6363(03) 00361-4.
    • (2003) Cardiovascular Research , vol.60 , pp. 96-107
    • Higuchi, M.L.1    Benvenuti, L.A.2    Martins Reis, M.3    Metzger, M.4
  • 20
    • 38549177533 scopus 로고    scopus 로고
    • Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5, 6, 7,8-tetrahydro-imidazo[1,2-a]pyridines
    • doi:10.1016/ j.bmc.2007.10.042
    • Ismail, M. A., Arafa, R. K., Wenzler, T., Brun, R., Tanious, F. A., Wilson, W. D. and Boykin, D. W. (2008). Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1, 2-a]pyridines. Bioorganic & Medicinal Chemistry 16, 683-691. doi:10.1016/ j.bmc.2007.10.042.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , pp. 683-691
    • Ismail, M.A.1    Arafa, R.K.2    Wenzler, T.3    Brun, R.4    Tanious, F.A.5    Wilson, W.D.6    Boykin, D.W.7
  • 22
    • 45549100534 scopus 로고    scopus 로고
    • Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT)
    • BENEFIT Investigators, doi:10.1016/j.ahj.2008.04.001
    • Marin-Neto, J. A., Rassi, A. Jr., Morillo, C. A., Avezum, A., Connolly, S. J., Sosa-Estani, S., Rosas, F. and Yusuf, S., BENEFIT Investigators (2008). Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). American Heart Journal 156, 37-43. doi:10.1016/j.ahj.2008.04.001.
    • (2008) American Heart Journal , vol.156 , pp. 37-43
    • Marin-Neto, J.A.1    Rassi Jr., A.2    Morillo, C.A.3    Avezum, A.4    Connolly, S.J.5    Sosa-Estani, S.6    Rosas, F.7    Yusuf, S.8
  • 23
    • 33744486606 scopus 로고    scopus 로고
    • Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes
    • doi: 10.1128/ AAC.00192-06
    • Mathis, A. M., Holman, J. L., Sturk, L. M., Ismail, M. A., Boykin, D. W., Tidwell, R. R. and Hall, J. E. (2006). Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrobial Agents and Chemotherapy 50, 2185-2191. doi: 10.1128/ AAC.00192-06.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , pp. 2185-2191
    • Mathis, A.M.1    Holman, J.L.2    Sturk, L.M.3    Ismail, M.A.4    Boykin, D.W.5    Tidwell, R.R.6    Hall, J.E.7
  • 25
    • 0022760004 scopus 로고
    • Interaction of Trypanosoma cruzi with heart muscle cells : UUltrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro
    • Meirelles, M. N., Araujo-Jorge, T. C., Miranda, C. F., De Souza, W. and Barbosa, H. S. (1986). Interaction of Trypanosoma cruzi with heart muscle cells : ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro. European Journal of Cell Biology 41, 198-206.
    • (1986) European Journal of Cell Biology , vol.41 , pp. 198-206
    • Meirelles, M.N.1    Araujo-Jorge, T.C.2    Miranda, C.F.3    De Souza, W.4    Barbosa, H.S.5
  • 26
    • 56949084429 scopus 로고    scopus 로고
    • Different cell death pathways induced by drugs in Trypanosoma cruzi: An ultrastructural study
    • doi:10.1016/j.micron.2008.08.003
    • Menna-Barreto, R. F., Salomã o, K., Dantas, A. P., Santa-Rita, R. M., Soares, M. J., Barbosa, H. S. and de Castro, S. L. (2009). Different cell death pathways induced by drugs in Trypanosoma cruzi: an ultrastructural study. Micron 40, 157-168. doi:10.1016/j.micron.2008.08.003.
    • (2009) Micron , vol.40 , pp. 157-168
    • Menna-Barreto, R.F.1    Salomão, K.2    Dantas, A.P.3    Santa-Rita, R.M.4    Soares, M.J.5    Barbosa, H.S.6    De Castro, S.L.7
  • 27
    • 57149087031 scopus 로고    scopus 로고
    • Prognostic impact of Chagas disease in the United States
    • doi:10.1016/j.ahj.2008.08.024
    • Milei, J., Guerri-Guttenberg, R. A., Grana, D. R. and Storino, R. (2009). Prognostic impact of Chagas disease in the United States. American Heart Journal 157, 22-29. doi:10.1016/j.ahj.2008.08.024.
    • (2009) American Heart Journal , vol.157 , pp. 22-29
    • Milei, J.1    Guerri-Guttenberg, R.A.2    Grana, D.R.3    Storino, R.4
  • 28
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation in cytotoxicity assays
    • Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation in cytotoxicity assays. Journal of Immunological Methods 65, 55-63.
    • (1983) Journal of Immunological Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 34547855487 scopus 로고    scopus 로고
    • An update on the management of Chagas cardiomiopathy
    • doi:10.1586/14787210.5.4.727
    • Rocha, M. O., Teixeira, M. M. and Ribeiro, A. L. (2007). An update on the management of Chagas cardiomiopathy. Expert Review of Anti-Infective Therapy 5, 727-743. doi:10.1586/14787210.5.4.727
    • (2007) Expert Review of Anti-Infective Therapy , vol.5 , pp. 727-743
    • Rocha, M.O.1    Teixeira, M.M.2    Ribeiro, A.L.3
  • 31
    • 44349139492 scopus 로고    scopus 로고
    • Ultrastructural alterations in organelles of parasitic protozoa induced by different classes of metabolic inhibitors
    • Rodrigues, J. C. and de Souza, W. (2008). Ultrastructural alterations in organelles of parasitic protozoa induced by different classes of metabolic inhibitors. Current Pharmaceutical Design 14, 925-938.
    • (2008) Current Pharmaceutical Design , vol.14 , pp. 925-938
    • Rodrigues, J.C.1    De Souza, W.2
  • 33
    • 33751240514 scopus 로고    scopus 로고
    • Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi
    • doi: 10.1007/ s00436-006-0250-258
    • Santa-Rita, R. M., Barbosa, H. S. and de Castro, S. L. (2006). Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi. Parasitology Research 100, 187-200. doi: 10.1007/ s00436-006-0250-258
    • (2006) Parasitology Research , vol.100 , pp. 187-200
    • Santa-Rita, R.M.1    Barbosa, H.S.2    De Castro, S.L.3
  • 37
    • 61449562202 scopus 로고    scopus 로고
    • Trypanosoma cruzi targets for new chemotherapeutic approaches
    • doi:10.1517/14728220802623881
    • Soeiro, M. N. C. and De Castro, S. L. (2009). Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opinion on Therapeutic Targets 13, 105-121. doi:10.1517/14728220802623881.
    • (2009) Expert Opinion on Therapeutic Targets , vol.13 , pp. 105-121
    • Soeiro, M.N.C.1    De Castro, S.L.2
  • 42
    • 0028171327 scopus 로고
    • Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei
    • Vercesi, A. E., Moreno, S. N. and Docampo, R. (1994). Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. The Biochemical Journal 304, 227-233.
    • (1994) The Biochemical Journal , vol.304 , pp. 227-233
    • Vercesi, A.E.1    Moreno, S.N.2    Docampo, R.3
  • 43
    • 32544437658 scopus 로고    scopus 로고
    • Diamidines as antitrypanosomal, antileishmanial and antimalarial agents
    • Werbovetz, K. (2006). Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Current Opinion in Investigational Drugs 7, 147-157.
    • (2006) Current Opinion in Investigational Drugs , vol.7 , pp. 147-157
    • Werbovetz, K.1
  • 44
    • 45849096432 scopus 로고    scopus 로고
    • Antiparasitic compounds that target DNA
    • doi:10.1016/j.biochi.2008.02.017
    • Wilson, W. D., Tanious, F. A. and Mathis, A. (2008). Antiparasitic compounds that target DNA. Biochimie 90, 999-1014. doi:10.1016/j.biochi.2008.02. 017.
    • (2008) Biochimie , vol.90 , pp. 999-1014
    • Wilson, W.D.1    Tanious, F.A.2    Mathis, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.