Dopaminergic-like cells from epigenetically reprogrammed mesenchymal stem cells

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 11, 2012, Pages 2708-2714

  Zhang, Zhiying ^a   Alexanian, Arshak R ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Dopamine; Epigenetic; Mesenchymal stem cells; Neural cells; Neurotrophins; Reprogramming

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NR4A2 PROTEIN, HUMAN; NUCLEAR RECEPTOR RELATED FACTOR 1;

ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DOPAMINERGIC NERVE CELL; GENETIC EPIGENESIS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

BIOLOGICAL MARKERS; BONE MARROW CELLS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOPAMINERGIC NEURONS; EPIGENESIS, GENETIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MESENCHYMAL STROMAL CELLS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2;

PARKINSONIA; RATTUS;

EID: 84868133333     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01591.x     Document Type: Article

References (22)

1. Geraerts M, Krylyshkina O, Debyser Z, et al. Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis. Stem Cells. 2007; 25: 263-70.
2. Toulouse A, Sullivan AM. Progress in Parkinson's disease - where do we stand? Prog Neurobiol. 2008; 85: 376-92.
3. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126: 663-76.
4. Okita K, Ichisaka T, Yamanaka S, et al. Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448: 313-7.
5. Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318: 1917-20.
6. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131: 861-72.
7. Eggenschwiler R, Cantz T. Induced pluripotent stem cells generated without viral integration. Hepatology. 2009; 49: 1048-9.
8. Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science. 2008; 322: 949-53.
9. Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009; 4: 472-6.
10. Lyssiotis CA, Walker J, Wu C, et al. Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells. Proc Natl Acad Sci USA. 2007; 104: 14982-7.
11. Schmittwolf C, Kirchhof N, Jauch A, et al. In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. EMBO J. 2005; 24: 554-66.
12. Harris DM, Hazan-Haley I, Coombes K, et al. Transformation of human mesenchymal cells and skin fibroblasts into hematopoietic cells. PLoS One. 2011; 6: e21250.
13. Eminli S, Foudi A, Stadtfeld M, et al. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet. 2009; 41: 968-76.
14. Zhang Z, Maiman DJ, Kurpad SN, et al. Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors. Cell Reprogram. 2011; 13: 385-90.
15. Zipori D. Mesenchymal stem cells: harnessing cell plasticity to tissue and organ repair. Blood Cells Mol Dis. 2004; 33: 211-5.
16. Zhang Z, Maiman DJ, Kurpad SN, et al. Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors. Cell Reprogram. 2011; 13: 385-90.
17. Alexanian AR. An efficient method for generation of neural-like cells from adult human bone marrow-derived mesenchymal stem cells. Regen Med. 2010; 5: 891-900.
18. Alexanian AR, Fehlings MG, Zhang Z, et al. Transplanted neurally modified bone marrow-derived mesenchymal stem cells promote tissue protection and locomotor recovery in spinal cord injured rats. Neurorehabil Neural Repair. 2011; 25: 873-80.
19. Grayson WL, Zhao F, Izadpanah R, et al. Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol. 2006; 207: 331-9.
20. Hung SP, Ho JH, Shih YR, et al. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res. 2012; 30: 260-6.
21. Basciano L, Nemos C, Foliguet B, et al. Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status. BMC Cell Biol. 2011; 12: 12.
22. Weijers EM, Van Den Broek LJ, Waaijman T, et al. The influence of hypoxia and fibrinogen variants on the expansion and differentiation of adipose tissue-derived mesenchymal stem cells. Tissue Eng Part A. 2011; 17: 2675-85.