Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors

Cellular Reprogramming

Volumn 13, Issue 5, 2011, Pages 385-390

  Zhang, Zhiying ^a   Maiman, Dennis J ^a   Kurpad, Shekar N ^a   Crowe, Maria J ^a   Alexanian, Arshak R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RNA;

ANIMAL CELL; ARTICLE; BONE MARROW; CHROMATIN; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; MORPHOLOGY; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, DIFFERENTIATION; BONE MARROW CELLS; CATS; CELL SURVIVAL; CELLS, CULTURED; CHROMATIN; ENZYME INHIBITORS; HUMANS; MESENCHYMAL STEM CELLS; NEURAL STEM CELLS; PLURIPOTENT STEM CELLS; SPINAL CORD INJURIES; TRANSPLANTATION, AUTOLOGOUS;

ANIMALIA; FELIDAE;

EID: 80053554317     PISSN: 21524971     EISSN: 21524998     Source Type: Journal    
DOI: 10.1089/cell.2011.0007     Document Type: Article

References (16)

1. Alexanian, A. (2010a). An efficient method for generation of neural-like cells from adult human bone marrow derived mesenchymal stem cells. Regen. Med. 5, 891-900.
2. Alexanian, A.R. (2005). Neural stem cells induce bone-marrow-derived mesenchymal stem cells to generate neural stem-like cells via juxtacrine and paracrine interactions. Exp. Cell Res. 310, 383-391. (Pubitemid 41457341)
3. Alexanian, A.R. (2007). Epigenetic modifiers promote efficient generation of neural-like cells from bone marrow-derived mesenchymal cells grown in neural environment. J. Cell Bio-chem. 100, 362-371. (Pubitemid 46146086)
4. Alexanian, A.R. (2010b). An efficient method for generation of neural-like cells from adult human bone marrow-derived mesenchymal stem cells. Regen. Med. 5, 891-900.
5. Alexanian, A.R., Maiman, D.J., Kurpad, S.N., et all. (2008). In vitro and in vivo characterization of neurally modified mesenchymal stem cells induced by epigenetic modifiers and neural stem cell environment. Stem Cells Dev. 17, 1123-1130.
6. Alexanian, A.R., Kwok, W.M., Pravdic, D., et al. (2010). Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats. Restor. Neurol. Neurosci. 28, 761-767.
7. Kim, D., Kim, C.H., Moon, J.I., et al. (2009). Generation of human induced pluripotent stem cells by direct delivery of repro-gramming proteins. Cell Stem Cell 4, 472-476.
8. Kunisato, A., Wakatsuki, M., Kodama, Y., et al. (2010). Generation of induced pluripotent stem (iPS) cells by efficient re-programming of adult bone marrow cells. Stem Cells Dev. 19, 229-238.
9. Lyssiotis, C.A., Walker, J., Wu, C., et al. (2007). Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells. Proc. Natl. Acad. Sci. USA 104, 14982-14987. (Pubitemid 47619579)
10. Masip, M., Veiga, A., Izpisua Belmonte, J.C., et al. (2010). Re-programming with defined factors: from induced plur-ipotency to induced transdifferentiation. Mol. Hum. Reprod. 16, 856-868.
11. Ohnuki, M., Takahashi, K., and Yamanaka S. (2009). Generation and characterization of human induced pluripotent stem cells. Curr. Protoc. Stem Cell Biol. Chapter 4, Unit 4A 2.
12. Ruau, D., Ensenat-Waser, R., Dinger, T.C., et al. (2008). Plur-ipotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells 26, 920-926.
13. Schmittwolf, C., Kirchhof, N., Jauch, A., et al. (2005). In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. EMBO J. 24, 554-566. (Pubitemid 40343257)
14. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. (Pubitemid 44233629)
15. Warren, L., Manos, P.D., Ahfeldt, T., et al. (2010). Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630.
16. Zhu, S., Li, W., Zhou, H., et al. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 7, 651-655.