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Volumn 17, Issue 21-22, 2012, Pages 1170-1174

A minimalist fragment approach for the design of natural-product-like synthetic scaffolds

Author keywords

[No Author keywords available]

Indexed keywords

ANISOMYCIN; ASCORBIC ACID; CARBON; MUSCARINE; NATURAL PRODUCT; NITROGEN; TETRAHYDROBIOPTERIN;

EID: 84868121976     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.05.013     Document Type: Short Survey
Times cited : (13)

References (28)
  • 1
    • 80052830823 scopus 로고    scopus 로고
    • How well do medicinal chemists learn from experience?
    • D.R. Cheshire How well do medicinal chemists learn from experience? Drug Discov. Today 16 2011 817 821
    • (2011) Drug Discov. Today , vol.16 , pp. 817-821
    • Cheshire, D.R.1
  • 2
    • 77952583878 scopus 로고    scopus 로고
    • Enhancements of screening collections to address areas of unmet medical need: An industry perspective
    • D.H. Drewry, and R. Macarron Enhancements of screening collections to address areas of unmet medical need: an industry perspective Curr. Opin. Chem. Biol. 14 2010 289 298
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 289-298
    • Drewry, D.H.1    MacArron, R.2
  • 4
    • 77149161768 scopus 로고    scopus 로고
    • BioCores: Identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery
    • R. Kombarov BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery Mol. Divers. 14 2009 193 200
    • (2009) Mol. Divers. , vol.14 , pp. 193-200
    • Kombarov, R.1
  • 5
    • 0033104653 scopus 로고    scopus 로고
    • Statistical investigation into the structural complementarity of natural products and synthetic compounds
    • DOI 10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0. CO;2-G
    • T. Henkel Statistical investigation into the structural complementarity of natural products and synthetic compounds Angew. Chem. Int. Ed. 38 1999 643 647 (Pubitemid 29129819)
    • (1999) Angewandte Chemie - International Edition , vol.38 , Issue.5 , pp. 643-647
    • Henkel, T.1    Brunne, R.M.2    Muller, H.3    Reichel, F.4
  • 6
    • 0035347869 scopus 로고    scopus 로고
    • Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
    • DOI 10.1021/cc000097l
    • M-L. Lee, and G. Schneider Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries J. Comb. Chem. 3 2001 284 289 (Pubitemid 33616450)
    • (2001) Journal of Combinatorial Chemistry , vol.3 , Issue.3 , pp. 284-289
    • Lee, M.-L.1    Schneider, G.2
  • 7
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • DOI 10.1016/j.cbpa.2004.04.010, PII S1367593104000560
    • A.M. Boldi Libraries from natural product-like scaffolds Curr. Opin. Chem. Biol. 8 2004 281 286 (Pubitemid 38759403)
    • (2004) Current Opinion in Chemical Biology , vol.8 , Issue.3 , pp. 281-286
    • Boldi, A.M.1
  • 8
    • 52649134945 scopus 로고    scopus 로고
    • Scaffold diversity of natural products: Inspiration for combinatorial library design
    • K. Grabowski Scaffold diversity of natural products: inspiration for combinatorial library design Nat. Prod. Rep. 25 2008 892 904
    • (2008) Nat. Prod. Rep. , vol.25 , pp. 892-904
    • Grabowski, K.1
  • 9
    • 77952545822 scopus 로고    scopus 로고
    • Expanding the range of druggable targets with natural product-based libraries: An academic perspective
    • R.A. Bauer Expanding the range of druggable targets with natural product-based libraries: an academic perspective Curr. Opin. Chem. Biol. 14 2010 308 314
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 308-314
    • Bauer, R.A.1
  • 10
    • 67651033682 scopus 로고    scopus 로고
    • Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity
    • S.C.K. Sukuru Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity J. Biomol. Screen. 14 2009 690 699
    • (2009) J. Biomol. Screen. , vol.14 , pp. 690-699
    • Sukuru, S.C.K.1
  • 11
    • 0037208308 scopus 로고    scopus 로고
    • Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry
    • M. Feher, and J.M. Schmidt Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry J. Chem. Information Comput. Sci. 43 2003 218 227
    • (2003) J. Chem. Information Comput. Sci. , vol.43 , pp. 218-227
    • Feher, M.1    Schmidt, J.M.2
  • 12
    • 42949115495 scopus 로고    scopus 로고
    • Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs
    • F. Petersen, R. Amstutz, Birkhäuser
    • P. Ertl, and A. Schuffenhauer Cheminformatics analysis of natural products: lessons from nature inspiring the design of new drugs F. Petersen, R. Amstutz, Progress in Drug Research. Natural Compounds as Drugs Vol. 2 2008 Birkhäuser 219 235
    • (2008) Progress in Drug Research. Natural Compounds As Drugs , vol.2 , pp. 219-235
    • Ertl, P.1    Schuffenhauer, A.2
  • 13
    • 84867893244 scopus 로고    scopus 로고
    • Physicochemical properties of natural based products versus synthetic chemicals
    • H. Zaid Physicochemical properties of natural based products versus synthetic chemicals Open Nutraceut. J. 3 2010 194 202
    • (2010) Open Nutraceut. J. , vol.3 , pp. 194-202
    • Zaid, H.1
  • 14
    • 39449121965 scopus 로고    scopus 로고
    • Natural product-likeness score and its application for prioritization of compound libraries
    • DOI 10.1021/ci700286x
    • P. Ertl Natural product-likeness score and its application for prioritization of compound libraries J. Chem. Information Model. 48 2008 68 74 (Pubitemid 351271051)
    • (2008) Journal of Chemical Information and Modeling , vol.48 , Issue.1 , pp. 68-74
    • Ertl, P.1    Roggo, S.2    Schuffenhauer, A.3
  • 16
    • 64549160613 scopus 로고    scopus 로고
    • Novel chemical space exploration via natural products
    • J. Rosen Novel chemical space exploration via natural products J. Med. Chem. 52 2009 1953 1962
    • (2009) J. Med. Chem. , vol.52 , pp. 1953-1962
    • Rosen, J.1
  • 17
    • 80053928594 scopus 로고    scopus 로고
    • What do medicinal chemists actually make? A 50-year retrospective
    • W.P. Walters What do medicinal chemists actually make? A 50-year retrospective J. Med. Chem. 54 2011 6405 6416
    • (2011) J. Med. Chem. , vol.54 , pp. 6405-6416
    • Walters, W.P.1
  • 18
    • 78249273274 scopus 로고    scopus 로고
    • Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries)
    • T.W.J. Cooper Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries) Angew. Chem. Int. Ed. 49 2010 8082 8091
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 8082-8091
    • Cooper, T.W.J.1
  • 20
    • 4444262413 scopus 로고    scopus 로고
    • A minimalist approach to fragment-based ligand design using common rings and linkers: Application to kinase inhibitors
    • DOI 10.1002/prot.20173
    • A.M. Aronov, and G.W. Bemis A minimalist approach to fragment-based ligand design using common rings and linkers: application to kinase inhibitors Proteins 57 2004 36 50 (Pubitemid 39195883)
    • (2004) Proteins: Structure, Function and Genetics , vol.57 , Issue.1 , pp. 36-50
    • Aronov, A.M.1    Bemis, G.W.2
  • 21
    • 79960524750 scopus 로고    scopus 로고
    • Minimalist and universal peptidomimetics
    • E. Ko Minimalist and universal peptidomimetics Chem. Soc. Rev. 40 2011 4411 4421
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 4411-4421
    • Ko, E.1
  • 22
    • 49949151887 scopus 로고    scopus 로고
    • Molecular diversity in the context of leadlikeness: Compound properties that enable effective biochemical screening
    • G.M. Rishton Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening Curr. Opin. Chem. Biol. 12 2008 340 351
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 340-351
    • Rishton, G.M.1
  • 23
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • DOI 10.1021/np068054v
    • D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70 2007 461 477 (Pubitemid 46595760)
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 24
    • 77952542911 scopus 로고    scopus 로고
    • Current strategies for diversity-oriented synthesis
    • S. Dandapani, and L.A. Marcaurelle Current strategies for diversity-oriented synthesis Curr. Opin. Chem. Biol. 14 2010 362 370
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 362-370
    • Dandapani, S.1    Marcaurelle, L.A.2
  • 25
    • 70549094244 scopus 로고    scopus 로고
    • Regioselective domino metathesis of unsymmetrical 7-oxanorbornenes with electron-rich vinyl acetate toward biologically active glutamate analogues
    • M. Oikawa Regioselective domino metathesis of unsymmetrical 7-oxanorbornenes with electron-rich vinyl acetate toward biologically active glutamate analogues Eur. J. Org. Chem. 32 2009 5531 5548
    • (2009) Eur. J. Org. Chem. , vol.32 , pp. 5531-5548
    • Oikawa, M.1
  • 27
    • 64349122942 scopus 로고    scopus 로고
    • Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2
    • L.A. Marcaurelle Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2 Bioorg. Med. Chem. Lett. 9 2009 2500 2503
    • (2009) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2500-2503
    • Marcaurelle, L.A.1
  • 28
    • 71049126548 scopus 로고    scopus 로고
    • Escape from flatland: Increasing saturation as an approach to improving clinical success
    • F. Lovering Escape from flatland: increasing saturation as an approach to improving clinical success J. Med. Chem. 52 2009 6752 6756
    • (2009) J. Med. Chem. , vol.52 , pp. 6752-6756
    • Lovering, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.