Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding to RNA substrate

FEBS Letters

Volumn 586, Issue 21, 2012, Pages 3865-3869

  Kim, Ji Eun ^a   Yoon, Soojin ^a   Mok, Hyejung ^a   Jung, Woong ^b   Kim, Dong Eun ^a  

^a Konkuk University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

DNAzyme; Peptide nucleic acid (PNA); RNA cleavage; Single nucleotide polymorphism (SNP)

Indexed keywords

ABELSON KINASE; DEOXYRIBOZYME; IMATINIB; MESSENGER RNA; PEPTIDE NUCLEIC ACID; RNA;

ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; GENE EXPRESSION; LEUKEMIA CELL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RNA BINDING; RNA CLEAVAGE; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DNA, CATALYTIC; GENES, ABL; GENETIC ENGINEERING; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS; PIPERAZINES; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRIMIDINES; RNA CLEAVAGE; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 84868117805     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.09.013     Document Type: Article

References (25)

1. J.J. McCarthy, and R. Hilfiker The use of single-nucleotide polymorphism maps in pharmacogenomics Nat. Biotechnol. 18 2000 505 508
2. G.Q. Daley, R.A. Van Etten, and D. Baltimore Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome Science 247 1990 824 830
3. S. Faderl, M. Talpaz, Z. Estrov, S. O'Brien, R. Kurzrock, and H.M. Kantarjian The biology of chronic myeloid leukemia N. Engl. J. Med. 341 1999 164 172
4. M. Steinberg Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia Clin. Ther. 29 2007 2289 2308
5. H.A. Bradeen, C.A. Eide, T. O'Hare, K.J. Johnson, S.G. Willis, F.Y. Lee, B.J. Druker, and M.W. Deininger Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations Blood 108 2006 2332 2338
6. S.W. Santoro, and G.F. Joyce A general purpose RNA-cleaving DNA enzyme Proc. Natl. Acad. Sci. U S A 94 1997 4262 4266
7. K. Park, B.R. Choi, Y.S. Kim, S. Shin, S.S. Hah, W. Jung, S. Oh, and D.E. Kim Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation Anal. Biochem. 414 2011 303 305
8. R.B. Denman Facilitator oligonucleotides increase ribozyme RNA binding to full-length RNA substrates in vitro FEBS Lett. 382 1996 116 120
9. E. Jankowsky, and B. Schwenzer Efficient improvement of hammerhead ribozyme mediated cleavage of long substrates by oligonucleotide facilitators Biochemistry 35 1996 15313 15321
10. E. Jankowsky, G. Strunk, and B. Schwenzer Peptide nucleic acid (PNA) is capable of enhancing hammerhead ribozyme activity with long but not with short RNA substrates Nucleic Acids Res. 25 1997 2690 2693
11. S. Horn, and B. Schwenzer Oligonucleotide facilitators enhance the catalytic activity of RNA-cleaving DNA enzymes Antisense Nucleic Acid Drug Dev. 9 1999 465 472
12. A.A. Fokina, M.A. Kuznetsova, M.N. Repkova, and A.G. Venyaminova Two-component 10-23 DNA enzymes Nucleosides Nucleotides Nucleic Acids 23 2004 1031 1035
13. S. Schubert, J.P. Furste, D. Werk, H.P. Grunert, H. Zeichhardt, V.A. Erdmann, and J. Kurreck Gaining target access for deoxyribozymes J. Mol. Biol. 339 2004 355 363
14. B. Vester, L.B. Lundberg, M.D. Sorensen, B.R. Babu, S. Douthwaite, and J. Wengel Improved RNA cleavage by LNAzyme derivatives of DNAzymes Biochem. Soc. Trans. 32 2004 37 40
15. M.R. Jakobsen, J. Haasnoot, J. Wengel, B. Berkhout, and J. Kjems Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites Retrovirology 4 2007 29
16. B. Vester, L.H. Hansen, L.B. Lundberg, B.R. Babu, M.D. Sorensen, J. Wengel, and S. Douthwaite Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets BMC Mol. Biol. 7 2006 19
17. P.E. Nielsen, M. Egholm, R.H. Berg, and O. Buchardt Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide Science 254 1991 1497 1500
18. M. Egholm, O. Buchardt, L. Christensen, C. Behrens, S.M. Freier, D.A. Driver, R.H. Berg, S.K. Kim, B. Norden, and P.E. Nielsen PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules Nature 365 1993 566 568
19. V.V. Demidov, M.V. Yavnilovich, B.P. Belotserkovskii, M.D. Frank-Kamenetskii, and P.E. Nielsen Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA Proc. Natl. Acad. Sci. U S A 92 1995 2637 2641
20. K. Kaihatsu, B.A. Janowski, and D.R. Corey Recognition of chromosomal DNA by PNAs Chem. Biol. 11 2004 749 758
21. H. Knudsen, and P.E. Nielsen Antisense properties of duplex- and triplex-forming PNAs Nucleic Acids Res. 24 1996 494 500
22. K.J. Jang, N.R. Lee, W.S. Yeo, Y.J. Jeong, and D.E. Kim Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase Biochem. Biophys. Res. Commun. 366 2008 738 744
23. D.E. Kim, and G.F. Joyce Cross-catalytic replication of an RNA ligase ribozyme Chem. Biol. 11 2004 1505 1512
24. S.E. Hamilton, C.G. Simmons, I.S. Kathiriya, and D.R. Corey Cellular delivery of peptide nucleic acids and inhibition of human telomerase Chem. Biol. 6 1999 343 351
25. B. Lee, K.B. Kim, S. Oh, J.S. Choi, J.S. Park, D.H. Min, and D.E. Kim Suppression of hepatitis C virus genome replication in cells with RNA-cleaving DNA enzymes and short-hairpin RNA Oligonucleotides 20 2010 285 296