Smaller is better for antibiotic discovery

ACS Chemical Biology

Volumn 4, Issue 6, 2009, Pages 397-399

  Waldrop, Grover L ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; BIOTIN CARBOXYLASE; BIOTIN CARBOXYLASE INHIBITOR; CARBOXYLASE; PYRIDOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HIGH THROUGHPUT SCREENING; IC 50; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BINDING SITES; CARBON-NITROGEN LIGASES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649249777     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb900122j     Document Type: Article

References (10)

1. Taubes, G. (2008) The bacteria fight back, Science 321, 356-361.
2. O'Shea, R., and Moser, H. E. (2008) Physicochemical properties of antibacterial compounds: Implications for drug discovery, J. Med. Chem. 51, 2871-2878. (Pubitemid 351706014)
3. Mochalkin, I., Miller, J. R., Narasimhan, L., Venkataraman, T., Erdman, P., Cox, P. B., Vara Prasad, J. V. N., Lightle, S., Huband, M. D., and Stover, C. K. (2009) Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches, ACS Chem. Biol. 4, 473-483.
4. Cronan, J. E., and Waldrop, G. L. (2002) Multisubunit acetyl-CoA carboxylases, Prog. Lipid Res. 41, 407-435.
5. Miller, J. R., Dunham, S., Mochalkin, I., Banotai, C., Bowman, M., Buist, S., Dunkle, B., Hanna, D., Harwood, H. J., Huband, M. D., Karnovsky, A., Kuhn, M., Limberakis, C., Liu, J. Y., Mehrens, S., Mueller, W. T., Narasimhan, L., Ogden, A., Ohren, J., Prasad, J. V. N. V., Shelly, J. A., Skerlos, L., Sulavik, M., Thomas, V. H., VanderRoest, S., Wang, L., Wang, Z., Whitton, A., Zhu, T., and Stover, C. K. (2009) A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore, Proc. Natl. Acad. Sci. U.S.A. 106, 1737-1742.
6. Walsh, C. T., and Fischbach, M. A. (2009) Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery, Proc. Natl. Acad. Sci. U.S.A. 106, 1689-1690.
7. Mochalkin, I., Miller, J. R., Evdokimov, A., Lightle, S., Yan, C., Stover, C. K., and Waldrop, G. L. (2008) Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase, Protein Sci. 17, 1706-1718.
8. Congreve, M., Chessari, G., Tisi, D., and Woodhead, A. J. (2008) Recent developments in fragment-based drug discovery, J. Med. Chem. 51, 3661-3680. (Pubitemid 351956496)
9. Hubbard, R. E. (2008) Fragment approaches in structure-based drug discovery, J. Synchrotron Radiat. 15, 227-230. (Pubitemid 351571008)
10. Brinster, S., Lamberet, G., Staels, B., Trieu-Cuot, P., Gruss, A., and Poyart, C. (2009) Type II fatty acid synthesis is not a suitable antibiotic target for Grampositive pathogens, Nature 458, 83-86.